Clinical phenotypes and survival of ...
Type de document :
Article dans une revue scientifique
PMID :
URL permanente :
Titre :
Clinical phenotypes and survival of pre-capillary pulmonary hypertension in systemic sclerosis.
Auteur(s) :
Launay, David [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Montani, David [Auteur]
Université Paris-Sud - Paris 11 [UP11]
Hassoun, Paul [Auteur]
Cottin, Vincent [Auteur]
Université Claude Bernard Lyon 1 [UCBL]
Le Pavec, Jerome [Auteur]
Université Paris-Sud - Paris 11 [UP11]
Clerson, Pierre [Auteur]
Impact de l'environnement chimique sur la santé humaine - ULR 4483 [IMPECS]
Sitbon, Olivier [Auteur]
Université Paris-Sud - Paris 11 [UP11]
Jais, Xavier [Auteur]
Université Paris-Sud - Paris 11 [UP11]
Savale, Laurent [Auteur]
Université Paris-Sud - Paris 11 [UP11]
Weatherald, Jason [Auteur]
Université Paris-Sud - Paris 11 [UP11]
Sobanski, Vincent [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Mathai Stephen, C [Auteur]
Shafiq, Majid [Auteur]
Cordier, Jean-Francois [Auteur]
Université Claude Bernard Lyon 1 [UCBL]
Hachulla, Eric [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Simonneau, Gerald [Auteur]
Université Paris-Sud - Paris 11 [UP11]
Humbert, Marc [Auteur]
Université Paris-Sud - Paris 11 [UP11]
Lille Inflammation Research International Center - U 995 [LIRIC]
Montani, David [Auteur]
Université Paris-Sud - Paris 11 [UP11]
Hassoun, Paul [Auteur]
Cottin, Vincent [Auteur]
Université Claude Bernard Lyon 1 [UCBL]
Le Pavec, Jerome [Auteur]
Université Paris-Sud - Paris 11 [UP11]
Clerson, Pierre [Auteur]
Impact de l'environnement chimique sur la santé humaine - ULR 4483 [IMPECS]
Sitbon, Olivier [Auteur]
Université Paris-Sud - Paris 11 [UP11]
Jais, Xavier [Auteur]
Université Paris-Sud - Paris 11 [UP11]
Savale, Laurent [Auteur]
Université Paris-Sud - Paris 11 [UP11]
Weatherald, Jason [Auteur]
Université Paris-Sud - Paris 11 [UP11]
Sobanski, Vincent [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Mathai Stephen, C [Auteur]
Shafiq, Majid [Auteur]
Cordier, Jean-Francois [Auteur]
Université Claude Bernard Lyon 1 [UCBL]
Hachulla, Eric [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Simonneau, Gerald [Auteur]
Université Paris-Sud - Paris 11 [UP11]
Humbert, Marc [Auteur]
Université Paris-Sud - Paris 11 [UP11]
Titre de la revue :
PLoS ONE
Nom court de la revue :
PLoS One
Numéro :
13
Pagination :
e0197112
Date de publication :
2018-05-15
ISSN :
1932-6203
Discipline(s) HAL :
Sciences du Vivant [q-bio]
Résumé en anglais : [en]
Pre-capillary pulmonary hypertension (PH) in systemic sclerosis (SSc) is a heterogeneous condition with an overall bad prognosis. The objective of this study was to identify and characterize homogeneous phenotypes by a ...
Lire la suite >Pre-capillary pulmonary hypertension (PH) in systemic sclerosis (SSc) is a heterogeneous condition with an overall bad prognosis. The objective of this study was to identify and characterize homogeneous phenotypes by a cluster analysis in SSc patients with PH. Patients were identified from two prospective cohorts from the US and France. Clinical, pulmonary function, high-resolution chest tomography, hemodynamic and survival data were extracted. We performed cluster analysis using the k-means method and compared survival between clusters using Cox regression analysis. Cluster analysis of 200 patients identified four homogenous phenotypes. Cluster C1 included patients with mild to moderate risk pulmonary arterial hypertension (PAH) with limited or no interstitial lung disease (ILD) and low DLCO with a 3-year survival of 81.5% (95% CI: 71.4–88.2). C2 had pre-capillary PH due to extensive ILD and worse 3-year survival compared to C1 (adjusted hazard ratio [HR] 3.14; 95% CI 1.66–5.94; p = 0.0004). C3 had severe PAH and a trend towards worse survival (HR 2.53; 95% CI 0.99–6.49; p = 0.052). Cluster C4 and C1 were similar with no difference in survival (HR 0.65; 95% CI 0.19–2.27, p = 0.507) but with a higher DLCO in C4. PH in SSc can be characterized into distinct clusters that differ in prognosis.Lire moins >
Lire la suite >Pre-capillary pulmonary hypertension (PH) in systemic sclerosis (SSc) is a heterogeneous condition with an overall bad prognosis. The objective of this study was to identify and characterize homogeneous phenotypes by a cluster analysis in SSc patients with PH. Patients were identified from two prospective cohorts from the US and France. Clinical, pulmonary function, high-resolution chest tomography, hemodynamic and survival data were extracted. We performed cluster analysis using the k-means method and compared survival between clusters using Cox regression analysis. Cluster analysis of 200 patients identified four homogenous phenotypes. Cluster C1 included patients with mild to moderate risk pulmonary arterial hypertension (PAH) with limited or no interstitial lung disease (ILD) and low DLCO with a 3-year survival of 81.5% (95% CI: 71.4–88.2). C2 had pre-capillary PH due to extensive ILD and worse 3-year survival compared to C1 (adjusted hazard ratio [HR] 3.14; 95% CI 1.66–5.94; p = 0.0004). C3 had severe PAH and a trend towards worse survival (HR 2.53; 95% CI 0.99–6.49; p = 0.052). Cluster C4 and C1 were similar with no difference in survival (HR 0.65; 95% CI 0.19–2.27, p = 0.507) but with a higher DLCO in C4. PH in SSc can be characterized into distinct clusters that differ in prognosis.Lire moins >
Langue :
Anglais
Audience :
Internationale
Vulgarisation :
Non
Établissement(s) :
Inserm
Université de Lille
CHU Lille
Université de Lille
CHU Lille
Collections :
Équipe(s) de recherche :
Immunity, inflammation and fibrsis in auto and allo-reactivity
Date de dépôt :
2019-03-01T14:26:53Z
2024-01-25T12:29:08Z
2024-01-25T12:29:08Z
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