Association between Rheumatoid Arthritis ...
Type de document :
Article dans une revue scientifique
DOI :
PMID :
URL permanente :
Titre :
Association between Rheumatoid Arthritis and Pulmonary Hypertension: Data from the French Pulmonary Hypertension Registry.
Auteur(s) :
Montani, David [Auteur]
Université Paris-Sud - Paris 11 [UP11]
Henry, Julien [Auteur]
Université Paris Descartes - Paris 5 [UPD5]
O''connell, Caroline [Auteur]
Université Paris-Saclay
Jais, Xavier [Auteur]
Université Paris-Saclay
Cottin, Vincent [Auteur]
Université Claude Bernard Lyon 1 [UCBL]
Launay, David [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Habib, Gilbert [Auteur]
Bourdin, Arnaud [Auteur]
Université de Montpellier [UM]
Jevnikar, Mitja [Auteur]
Université Paris-Saclay
Savale, Laurent [Auteur]
Université Paris-Saclay
Rottat, Laurence [Auteur]
Université Paris-Saclay
Simonneau, Gerald [Auteur]
Université Paris-Saclay
Sitbon, Olivier [Auteur]
Université Paris-Saclay
Humbert, Marc [Auteur]
Université Paris-Saclay
Allanore, Yannick [Auteur]
Université Paris Descartes - Paris 5 [UPD5]
Université Paris-Sud - Paris 11 [UP11]
Henry, Julien [Auteur]
Université Paris Descartes - Paris 5 [UPD5]
O''connell, Caroline [Auteur]
Université Paris-Saclay
Jais, Xavier [Auteur]
Université Paris-Saclay
Cottin, Vincent [Auteur]
Université Claude Bernard Lyon 1 [UCBL]
Launay, David [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Habib, Gilbert [Auteur]
Bourdin, Arnaud [Auteur]
Université de Montpellier [UM]
Jevnikar, Mitja [Auteur]
Université Paris-Saclay
Savale, Laurent [Auteur]
Université Paris-Saclay
Rottat, Laurence [Auteur]
Université Paris-Saclay
Simonneau, Gerald [Auteur]
Université Paris-Saclay
Sitbon, Olivier [Auteur]
Université Paris-Saclay
Humbert, Marc [Auteur]
Université Paris-Saclay
Allanore, Yannick [Auteur]
Université Paris Descartes - Paris 5 [UPD5]
Titre de la revue :
Respiration
Nom court de la revue :
Respiration
Numéro :
95
Pagination :
244–250
Date de publication :
2018-04
Mot(s)-clé(s) :
Connective tissue disease
Rheumatoid arthritis
Pulmonary hypertension
Rheumatoid arthritis
Pulmonary hypertension
Discipline(s) HAL :
Sciences du Vivant [q-bio]
Résumé en anglais : [en]
Background: Precapillary pulmonary hypertension (PH), and particularly pulmonary arterial hypertension (PAH), is a life-threatening complication of connective tissue diseases (systemic sclerosis, systemic lupus erythematosus, ...
Lire la suite >Background: Precapillary pulmonary hypertension (PH), and particularly pulmonary arterial hypertension (PAH), is a life-threatening complication of connective tissue diseases (systemic sclerosis, systemic lupus erythematosus, and mixed connective tissue disease). The relationship between PH and rheumatoid arthritis (RA) has not been clearly established. Objectives: The aim of the study was to evaluate the relationship between precapillary PH and RA. Methods: We identified patients with PH and suspected RA included in the French PH Registry between 1 May 2004 and 31 December 2012 and evaluated the prevalence of confirmed RA in this population. RA phenotypes, clinical, functional, and hemodynamic data, and patient outcomes were recorded. Results: RA was confirmed in 20 patients (70% female; mean age 52 years) with precapillary PH, including 10 patients with PAH, 6 with severe PH due to lung disease, and 4 with chronic thromboembolic PH. The prevalence of RA was 0.35% (95% CI: 0.23–0.54) in the French PH Registry and 0.58% (95% CI: 0.30–1.11) in idiopathic PAH, comparable to that in the general population. The RA phenotype was characterized by the presence of specific RA autoantibodies and joint erosions in 75% of the patients. The outcomes of PH in the RA patients were unremarkable compared to those in other patients from the registry, and RA therapies had no major impact on the cardiopulmonary parameters. Conclusion: When precapillary PH occurs in RA patients, all PH subsets may be identified. The RA prevalence in the French PH Registry is similar to that in the general population, which does not support a specific association or an indication for PH screening in RA patients.Lire moins >
Lire la suite >Background: Precapillary pulmonary hypertension (PH), and particularly pulmonary arterial hypertension (PAH), is a life-threatening complication of connective tissue diseases (systemic sclerosis, systemic lupus erythematosus, and mixed connective tissue disease). The relationship between PH and rheumatoid arthritis (RA) has not been clearly established. Objectives: The aim of the study was to evaluate the relationship between precapillary PH and RA. Methods: We identified patients with PH and suspected RA included in the French PH Registry between 1 May 2004 and 31 December 2012 and evaluated the prevalence of confirmed RA in this population. RA phenotypes, clinical, functional, and hemodynamic data, and patient outcomes were recorded. Results: RA was confirmed in 20 patients (70% female; mean age 52 years) with precapillary PH, including 10 patients with PAH, 6 with severe PH due to lung disease, and 4 with chronic thromboembolic PH. The prevalence of RA was 0.35% (95% CI: 0.23–0.54) in the French PH Registry and 0.58% (95% CI: 0.30–1.11) in idiopathic PAH, comparable to that in the general population. The RA phenotype was characterized by the presence of specific RA autoantibodies and joint erosions in 75% of the patients. The outcomes of PH in the RA patients were unremarkable compared to those in other patients from the registry, and RA therapies had no major impact on the cardiopulmonary parameters. Conclusion: When precapillary PH occurs in RA patients, all PH subsets may be identified. The RA prevalence in the French PH Registry is similar to that in the general population, which does not support a specific association or an indication for PH screening in RA patients.Lire moins >
Langue :
Anglais
Audience :
Internationale
Vulgarisation :
Non
Établissement(s) :
Inserm
Université de Lille
CHU Lille
Université de Lille
CHU Lille
Équipe(s) de recherche :
Immunity, inflammation and fibrsis in auto and allo-reactivity
Date de dépôt :
2019-03-01T14:34:49Z
2023-12-13T16:01:26Z
2023-12-13T16:01:26Z
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