Impact of subglottic secretion drainage ...
Type de document :
Article dans une revue scientifique
DOI :
PMID :
URL permanente :
Titre :
Impact of subglottic secretion drainage on microaspiration in critically ill patients: a prospective observational study
Auteur(s) :
Millot, Guillaume [Auteur]
Boddaert, Pauline [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Parmentier-Decrucq, Erika [Auteur]
Palud, Aurore [Auteur]
Balduyck, Malika [Auteur]
497295|||Maladies RAres du DEveloppement embryonnaire et du MEtabolisme : du Phénotype au Génotype et à la Fonction - ULR 7364 [RADEME]
Maboudou, Patrice [Auteur]
Zerimech, Farid [Auteur]
Impact de l'environnement chimique sur la santé humaine - ULR 4483 [IMPECS]
Wallet, Frederic [Auteur]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Preau, Sebastien [Auteur]
Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement (RID-AGE) - U1167
498252|||Lille Inflammation Research International Center - U 995 [LIRIC]
Nseir, Saad [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Boddaert, Pauline [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Parmentier-Decrucq, Erika [Auteur]
Palud, Aurore [Auteur]
Balduyck, Malika [Auteur]
497295|||Maladies RAres du DEveloppement embryonnaire et du MEtabolisme : du Phénotype au Génotype et à la Fonction - ULR 7364 [RADEME]
Maboudou, Patrice [Auteur]
Zerimech, Farid [Auteur]
Impact de l'environnement chimique sur la santé humaine - ULR 4483 [IMPECS]
Wallet, Frederic [Auteur]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Preau, Sebastien [Auteur]
Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement (RID-AGE) - U1167
498252|||Lille Inflammation Research International Center - U 995 [LIRIC]
Nseir, Saad [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Titre de la revue :
Annals of translational medicine
Nom court de la revue :
Ann. Transl. Med.
Numéro :
6
Date de publication :
2018-11-13
ISSN :
2305-5839
Mot(s)-clé(s) :
microaspiration
Ventilator-associated pneumonia (VAP)
subglottic secretion drainage (SSD)
Ventilator-associated pneumonia (VAP)
subglottic secretion drainage (SSD)
Discipline(s) HAL :
Sciences du Vivant [q-bio]
Résumé en anglais : [en]
Background: Microaspiration is a major factor in ventilator-associated pneumonia (VAP) pathophysiology. Subglottic secretion drainage (SSD) aims at reducing its incidence.
Methods: Single-center prospective observational ...
Lire la suite >Background: Microaspiration is a major factor in ventilator-associated pneumonia (VAP) pathophysiology. Subglottic secretion drainage (SSD) aims at reducing its incidence. Methods: Single-center prospective observational study, performed in a French intensive care unit (ICU) from March 2012 to April 2013, including adult patients mechanically ventilated for at least 24 hours divided in two groups: patients in the SSD group intubated using tracheal tubes allowing SSD and patients in the control group intubated with standard tracheal tubes. Pepsin and salivary amylase concentrations were measured for 24 hours in all tracheal aspirates. Primary objective was to determine the impact of SSD on gastric or oropharyngeal microaspiration using pepsin or amylase concentration in tracheal aspirates. Results: Fifty-five patients were included in the SSD group and 45 in the control group. No difference was found between groups regarding the incidence of microaspiration defined as at least one tracheal aspirate positive for either pepsin or amylase [49 (89%) vs. 37 (82%), P=0.469]. Percentage of patients with VAP [16 (29%) vs. 11 (24%), P=0.656], ventilator-associated tracheobronchitis (VAT) [7 (13%) vs. 4 (9%), P=0.750] or early airway colonization [15 (35%) vs. 8 (18%), P=0.219] were not significantly different in study groups. Conclusions: SSD did not reduce the incidence of microaspiration, VAP, VAT or airway colonization in this observational study.Lire moins >
Lire la suite >Background: Microaspiration is a major factor in ventilator-associated pneumonia (VAP) pathophysiology. Subglottic secretion drainage (SSD) aims at reducing its incidence. Methods: Single-center prospective observational study, performed in a French intensive care unit (ICU) from March 2012 to April 2013, including adult patients mechanically ventilated for at least 24 hours divided in two groups: patients in the SSD group intubated using tracheal tubes allowing SSD and patients in the control group intubated with standard tracheal tubes. Pepsin and salivary amylase concentrations were measured for 24 hours in all tracheal aspirates. Primary objective was to determine the impact of SSD on gastric or oropharyngeal microaspiration using pepsin or amylase concentration in tracheal aspirates. Results: Fifty-five patients were included in the SSD group and 45 in the control group. No difference was found between groups regarding the incidence of microaspiration defined as at least one tracheal aspirate positive for either pepsin or amylase [49 (89%) vs. 37 (82%), P=0.469]. Percentage of patients with VAP [16 (29%) vs. 11 (24%), P=0.656], ventilator-associated tracheobronchitis (VAT) [7 (13%) vs. 4 (9%), P=0.750] or early airway colonization [15 (35%) vs. 8 (18%), P=0.219] were not significantly different in study groups. Conclusions: SSD did not reduce the incidence of microaspiration, VAP, VAT or airway colonization in this observational study.Lire moins >
Langue :
Anglais
Audience :
Internationale
Vulgarisation :
Non
Établissement(s) :
Inserm
Université de Lille
CHU Lille
CNRS
Institut Pasteur de Lille
Université de Lille
CHU Lille
CNRS
Institut Pasteur de Lille
Collections :
- Centre d'Infection et d'Immunité de Lille (CIIL) - U1019 - UMR 9017
- Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement (RID-AGE) - U1167
- IMPact de l'Environnement Chimique sur la Santé humaine (IMPECS) - ULR 4483
- Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
- Maladies Rares du Développement : Génétique, Régulation et Protéomique (RADEME) - ULR 7364
Équipe(s) de recherche :
Fungal associated invasive and inflammatory diseases
Glycation from inflammation to aging
Glycation from inflammation to aging
Date de dépôt :
2019-03-01T14:35:09Z
2021-06-28T12:50:20Z
2024-01-29T08:12:50Z
2024-01-29T10:04:46Z
2021-06-28T12:50:20Z
2024-01-29T08:12:50Z
2024-01-29T10:04:46Z
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- 22121-PB1-2246-R3.pdf
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