Title :

Altered signal intensity of active enhancing inflammatory lesions using post-contrast double inversion recovery MR sequence

Author(s) :

Hodel, Jerome [Auteur]
Badr, Sammy [Auteur]
Marrow Adiposity & Bone Lab [MABLab] - ULR 4490
Outteryck, Olivier [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Lebert, Paul [Auteur]
Chechin, David [Auteur]
Benadjaoud Mohamed, Amine [Auteur]
Pruvo, Jean-Pierre [Auteur]
Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 [TCDV]
Vermersch, Patrick [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Leclerc, Xavier [Auteur]
Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 [TCDV]

Journal title :

European radiology

Abbreviated title :

Eur. Radiol.

Volume number :

27

Pages :

637-641

Publication date :

2017-02-01

ISSN :

0938-7994

Keyword(s) :

Mesh:Contrast Media*
Mesh:Image Enhancement
Mesh:Brain/pathology
Mesh:Gadolinium*
Mesh:Multiple Sclerosis/pathology
Mesh:Multiple Sclerosis/diagnostic imaging*
Mesh:Male
Mesh:Adult
Mesh:Brain/diagnostic imaging*
Mesh:Observer Variation
Mesh:Humans
Mesh:Young Adult
Mesh:Magnetic Resonance Imaging/methods*
Mesh:Image Processing
Mesh:Computer-Assisted/methods*
Mesh:Female
Multiple sclerosis
Double inversion recovery MR sequence
Gadolinium-based contrast agent
Clinically isolated syndrome
Active enhancing inflammatory lesions

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

OBJECTIVE: We aimed at establishing the impact upon gadolinium administration on the conspicuity of active enhancing multiple sclerosis (MS) lesions using double inversion recovery (DIR) at 3T. METHODS: 15 consecutive ...
Show more >OBJECTIVE: We aimed at establishing the impact upon gadolinium administration on the conspicuity of active enhancing multiple sclerosis (MS) lesions using double inversion recovery (DIR) at 3T. METHODS: 15 consecutive patients with MS (n=8) or a clinically isolated syndrome (n=7) underwent pre and post-contrast DIR in addition to T2-weighted, FLAIR, pre and post-contrast T1-weighted sequences. First, two neuroradiologists located and marked all the enhancing MS lesions visible in consensus. Second, two other neuroradiologists, blinded to other sequences than DIR, independently assessed the SI changes from pre to post-contrast DIR images for each enhancing lesion, according to a 4-point-scale: increased SI (grade 1), absence of change (grade 2), lesion being partially (grade 3) or completely masked on post-contrast DIR images (grade 4). RESULTS: 246 MS lesions were detected including 26 enhancing on post-contrast T1-weighted images in 9 patients. The two blinded readers concluded to a decreased signal-intensity on post-contrast DIR images for all the 26 enhancing MS lesions (14 of grade 3 and 12 of grade 4). Inter-observer agreement was excellent, Kappa=0.85 (0.75 - 0.94). Using DIR post-contrast leads to altered signal-intensity of enhancing active MS lesions, ranging from partial to complete signal-loss. CONCLUSIONS: Our study strongly suggests the use of DIR before gadolinium administration. CONCLUSIONS: • DIR has gained widespread use in MS. • MRI protocols for MS patients usually contain several post-contrast sequences. • Signal-intensity of enhancing MS lesions is altered using DIR post-contrast. • Our study strongly suggests the use of DIR before gadolinium administration.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Inserm
Université de Lille
CHU Lille
CNRS

Collections :

• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Research team(s) :

Immunity, inflammation and fibrsis in auto and allo-reactivity

Submission date :

2019-03-01T15:16:09Z
2019-11-18T13:24:05Z