Chronic ingestion of cadmium and lead ...
Type de document :
Compte-rendu et recension critique d'ouvrage
PMID :
Titre :
Chronic ingestion of cadmium and lead alters the bioavailability of essential and heavy metals, gene expression pathways and genotoxicity in mouse intestine
Auteur(s) :
Breton, Jérôme [Auteur]
Lactic Acid Bacteria & Mucosal Immunity - CIIL
Le Clère, Kelly [Auteur]
Institut Pasteur de Lille
Daniel, Catherine [Auteur]
Lactic Acid Bacteria & Mucosal Immunity - CIIL
Sauty, Mathieu [Auteur]
Institut Pasteur de Lille
Nakab, Lauren [Auteur]
Institut Pasteur de Lille
Chassat, Thierry [Auteur]
Institut Pasteur de Lille
Dewulf, Joëlle [Auteur]
Lactic Acid Bacteria & Mucosal Immunity - CIIL
Penet, Sylvie [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Carnoy, Christophe [Auteur]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Thomas, Patrick [Auteur]
Institut Pasteur de Lille
Pot, Bruno [Auteur]
Lactic Acid Bacteria & Mucosal Immunity - CIIL
Nesslany, Fabrice [Auteur]
Institut Pasteur de Lille
Foligné, Benoît [Auteur correspondant]
Lactic Acid Bacteria & Mucosal Immunity - CIIL
Lactic Acid Bacteria & Mucosal Immunity - CIIL
Le Clère, Kelly [Auteur]
Institut Pasteur de Lille
Daniel, Catherine [Auteur]
Lactic Acid Bacteria & Mucosal Immunity - CIIL
Sauty, Mathieu [Auteur]
Institut Pasteur de Lille
Nakab, Lauren [Auteur]
Institut Pasteur de Lille
Chassat, Thierry [Auteur]
Institut Pasteur de Lille
Dewulf, Joëlle [Auteur]
Lactic Acid Bacteria & Mucosal Immunity - CIIL
Penet, Sylvie [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Carnoy, Christophe [Auteur]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Thomas, Patrick [Auteur]
Institut Pasteur de Lille
Pot, Bruno [Auteur]
Lactic Acid Bacteria & Mucosal Immunity - CIIL
Nesslany, Fabrice [Auteur]
Institut Pasteur de Lille
Foligné, Benoît [Auteur correspondant]
Lactic Acid Bacteria & Mucosal Immunity - CIIL
Titre de la revue :
Archives of Toxicology
Pagination :
1787-1795
Éditeur :
Springer Verlag
Date de publication :
2013-03-17
ISSN :
0340-5761
Mot(s)-clé(s) en anglais :
Cadmium
Lead
Intestine
Bioavailability
Gene expression
Genotoxicity
Mice
Lead
Intestine
Bioavailability
Gene expression
Genotoxicity
Mice
Discipline(s) HAL :
Sciences du Vivant [q-bio]
Résumé en anglais : [en]
Chronic ingestion of environmental heavy metals such as lead (Pb) and cadmium (Cd) causes various well-documented pathologies in specific target organs following their intestinal absorption and subsequent accumulation. ...
Lire la suite >Chronic ingestion of environmental heavy metals such as lead (Pb) and cadmium (Cd) causes various well-documented pathologies in specific target organs following their intestinal absorption and subsequent accumulation. However, little is known about the direct impact of the non-absorbed heavy metals on the small intestine and the colon homeostasis. The aim of our study was to compare the specific bioaccumulation and retention of Cd and Pb and their effect on the essential metal balance in primary organs, with those occurring specifically in the gastrointestinal tract of mice. Various doses of Cd (5, 20 and 100 mg l−1) and Pb (100 and 500 mg l−1) chloride salts were provided in drinking water for subchronic to chronic exposures (4, 8 and 12 weeks). In contrast to a clear dose- and time-dependent accumulation in target organs, results showed that intestines are poor accumulators for Cd and Pb. Notwithstanding, changes in gene expression of representative intestinal markers revealed that the transport-, oxidative- and inflammatory status of the gut epithelium of the duodenum, ileum and colon were specifically affected by both heavy metal species. Additionally, in vivo comet assay used to evaluate the impact of heavy metals on DNA damage showed clear genotoxic activities of Cd, on both the upper and distal parts of the gastrointestinal tract. Altogether, these results outline the resilience of the gut which balances the various effects of chronic Cd and Pb in the intestinal mucosa. Collectively, it provides useful information for the risk assessment of heavy metals in gut homeostasis and further disease’s susceptibility.Lire moins >
Lire la suite >Chronic ingestion of environmental heavy metals such as lead (Pb) and cadmium (Cd) causes various well-documented pathologies in specific target organs following their intestinal absorption and subsequent accumulation. However, little is known about the direct impact of the non-absorbed heavy metals on the small intestine and the colon homeostasis. The aim of our study was to compare the specific bioaccumulation and retention of Cd and Pb and their effect on the essential metal balance in primary organs, with those occurring specifically in the gastrointestinal tract of mice. Various doses of Cd (5, 20 and 100 mg l−1) and Pb (100 and 500 mg l−1) chloride salts were provided in drinking water for subchronic to chronic exposures (4, 8 and 12 weeks). In contrast to a clear dose- and time-dependent accumulation in target organs, results showed that intestines are poor accumulators for Cd and Pb. Notwithstanding, changes in gene expression of representative intestinal markers revealed that the transport-, oxidative- and inflammatory status of the gut epithelium of the duodenum, ileum and colon were specifically affected by both heavy metal species. Additionally, in vivo comet assay used to evaluate the impact of heavy metals on DNA damage showed clear genotoxic activities of Cd, on both the upper and distal parts of the gastrointestinal tract. Altogether, these results outline the resilience of the gut which balances the various effects of chronic Cd and Pb in the intestinal mucosa. Collectively, it provides useful information for the risk assessment of heavy metals in gut homeostasis and further disease’s susceptibility.Lire moins >
Langue :
Anglais
Vulgarisation :
Non
Source :
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