Title :

Activity-dependent regulation of myelin maintenance in the adult rat.

Author(s) :

Canu, Marie-Helene [Auteur]
Unité de Recherche Pluridisciplinaire Sport, Santé, Société (URePSSS) - ULR 7369 - ULR 4488 [URePSSS]
Carnaud, Michèle [Auteur]
Institut du Fer à Moulin
Picquet, Florence [Auteur]
Unité de Recherche Pluridisciplinaire Sport, Santé, Société (URePSSS) - EA 7369
Goutebroze, Laurence [Auteur]
Institut du Fer à Moulin [IFM - Inserm U1270 - SU]

Journal title :

Brain research

Abbreviated title :

Brain Res

Volume number :

1252

Pages :

45-51

Publication date :

2009-02-03

ISSN :

1872-6240

English keyword(s) :

Animals
Axons
Hindlimb Suspension
Male
Microscopy, Fluorescence
Motor Activity
Myelin Sheath
Nerve Fibers, Myelinated
Neural Conduction
Neuronal Plasticity
Peripheral Nerves
Radial Nerve
Ranvier's Nodes
Rats
Rats, Wistar

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Hindlimb unloading (HU) is known to induce changes in the neuromuscular system. However, no data describing the effects of HU on morphological characteristics of peripheral nerve have been reported so far. Therefore, we ...
Show more >Hindlimb unloading (HU) is known to induce changes in the neuromuscular system. However, no data describing the effects of HU on morphological characteristics of peripheral nerve have been reported so far. Therefore, we used soleus and radial nerves obtained from control and rats submitted to 14 days of HU to study the consequences of a decrease (soleus) or an increase (radial) in neural activity on its morphology. The mean number of fibers was not changed after HU. The soleus nerve axon diameter was weakly affected after HU, whereas the myelin thickness was reduced. For the radial nerve, both axon and fiber diameter were increased, and the myelin thickness and internodal distance were higher in HU rats. These results suggest that regulation of myelin maintenance undergoes plastic mechanisms. Neural activity and/or neural pattern might be essential in the maintenance of myelin sheath in adults.Show less >

Language :

Anglais

Peer reviewed article :

Oui

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
Univ. Artois
Univ. Littoral Côte d’Opale

Collections :

• Unité de Recherche Pluridisciplinaire Sport, Santé, Société (URePSSS) - ULR 7369

Research team(s) :

Activité Physique, Muscle, Santé (APMS)

Submission date :

2021-08-10T16:32:43Z
2021-09-01T09:02:47Z