Gel-forming mucin interactome drives mucus ...
Document type :
Article dans une revue scientifique
PMID :
Permalink :
Title :
Gel-forming mucin interactome drives mucus viscoelasticity
Author(s) :
Demouveaux, Bastien [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Gouyer, Valérie [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
gottrand, Fréderic [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Narita, Tetsuharu [Auteur]
Desseyn, Jean-Luc [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Lille Inflammation Research International Center - U 995 [LIRIC]
Gouyer, Valérie [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
gottrand, Fréderic [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Narita, Tetsuharu [Auteur]
Desseyn, Jean-Luc [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Journal title :
Advances in colloid and interface science
Abbreviated title :
Adv. Colloid Interface Sci.
Volume number :
252
Pages :
69-82
Publisher :
Elsevier
Publication date :
2018-02-01
ISSN :
0001-8686
Keyword(s) :
Mucus
Cystic fibrosis
Viscoelasticity
CYS domain
Gel-forming mucin
Cystic fibrosis
Viscoelasticity
CYS domain
Gel-forming mucin
HAL domain(s) :
Sciences du Vivant [q-bio]
English abstract : [en]
Mucus is a hydrogel that constitutes the first innate defense in all mammals. The main organic component of mucus, gel-forming mucins, forms a complex network through both reversible and irreversible interactions that drive ...
Show more >Mucus is a hydrogel that constitutes the first innate defense in all mammals. The main organic component of mucus, gel-forming mucins, forms a complex network through both reversible and irreversible interactions that drive mucus gel formation. Significant advances in the understanding of irreversible gel-forming mucins assembly have been made using recombinant protein approaches. However, little is known about the reversible interactions that may finely modulate mucus viscoelasticity, which can be characterized using rheology. This approach can be used to investigate both the nature of gel-forming mucins interactions and factors that influence hydrogel formation. This knowledge is directly relevant to the development of new drugs to modulate mucus viscoelasticity and to restore normal mucus functions in diseases such as in cystic fibrosis. The aim of the present review is to summarize the current knowledge about the relationship between the mucus protein matrix and its functions, with emphasis on mucus viscoelasticity.Show less >
Show more >Mucus is a hydrogel that constitutes the first innate defense in all mammals. The main organic component of mucus, gel-forming mucins, forms a complex network through both reversible and irreversible interactions that drive mucus gel formation. Significant advances in the understanding of irreversible gel-forming mucins assembly have been made using recombinant protein approaches. However, little is known about the reversible interactions that may finely modulate mucus viscoelasticity, which can be characterized using rheology. This approach can be used to investigate both the nature of gel-forming mucins interactions and factors that influence hydrogel formation. This knowledge is directly relevant to the development of new drugs to modulate mucus viscoelasticity and to restore normal mucus functions in diseases such as in cystic fibrosis. The aim of the present review is to summarize the current knowledge about the relationship between the mucus protein matrix and its functions, with emphasis on mucus viscoelasticity.Show less >
Language :
Anglais
Audience :
Internationale
Popular science :
Non
Administrative institution(s) :
Inserm
Université de Lille
CHU Lille
Université de Lille
CHU Lille
Research team(s) :
Nutritional modulation of inflammation and infection
Submission date :
2019-03-01T15:24:45Z
2021-05-14T10:51:24Z
2022-06-29T07:34:57Z
2021-05-14T10:51:24Z
2022-06-29T07:34:57Z
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