Gel-forming mucin interactome drives mucus ...
Type de document :
Article dans une revue scientifique
PMID :
URL permanente :
Titre :
Gel-forming mucin interactome drives mucus viscoelasticity
Auteur(s) :
Demouveaux, Bastien [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Gouyer, Valérie [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
gottrand, Fréderic [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Narita, Tetsuharu [Auteur]
Desseyn, Jean-Luc [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Lille Inflammation Research International Center - U 995 [LIRIC]
Gouyer, Valérie [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
gottrand, Fréderic [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Narita, Tetsuharu [Auteur]
Desseyn, Jean-Luc [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Titre de la revue :
Advances in colloid and interface science
Nom court de la revue :
Adv. Colloid Interface Sci.
Numéro :
252
Pagination :
69-82
Éditeur :
Elsevier
Date de publication :
2018-02-01
ISSN :
0001-8686
Mot(s)-clé(s) :
Mucus
Cystic fibrosis
Viscoelasticity
CYS domain
Gel-forming mucin
Cystic fibrosis
Viscoelasticity
CYS domain
Gel-forming mucin
Discipline(s) HAL :
Sciences du Vivant [q-bio]
Résumé en anglais : [en]
Mucus is a hydrogel that constitutes the first innate defense in all mammals. The main organic component of mucus, gel-forming mucins, forms a complex network through both reversible and irreversible interactions that drive ...
Lire la suite >Mucus is a hydrogel that constitutes the first innate defense in all mammals. The main organic component of mucus, gel-forming mucins, forms a complex network through both reversible and irreversible interactions that drive mucus gel formation. Significant advances in the understanding of irreversible gel-forming mucins assembly have been made using recombinant protein approaches. However, little is known about the reversible interactions that may finely modulate mucus viscoelasticity, which can be characterized using rheology. This approach can be used to investigate both the nature of gel-forming mucins interactions and factors that influence hydrogel formation. This knowledge is directly relevant to the development of new drugs to modulate mucus viscoelasticity and to restore normal mucus functions in diseases such as in cystic fibrosis. The aim of the present review is to summarize the current knowledge about the relationship between the mucus protein matrix and its functions, with emphasis on mucus viscoelasticity.Lire moins >
Lire la suite >Mucus is a hydrogel that constitutes the first innate defense in all mammals. The main organic component of mucus, gel-forming mucins, forms a complex network through both reversible and irreversible interactions that drive mucus gel formation. Significant advances in the understanding of irreversible gel-forming mucins assembly have been made using recombinant protein approaches. However, little is known about the reversible interactions that may finely modulate mucus viscoelasticity, which can be characterized using rheology. This approach can be used to investigate both the nature of gel-forming mucins interactions and factors that influence hydrogel formation. This knowledge is directly relevant to the development of new drugs to modulate mucus viscoelasticity and to restore normal mucus functions in diseases such as in cystic fibrosis. The aim of the present review is to summarize the current knowledge about the relationship between the mucus protein matrix and its functions, with emphasis on mucus viscoelasticity.Lire moins >
Langue :
Anglais
Audience :
Internationale
Vulgarisation :
Non
Établissement(s) :
Inserm
Université de Lille
CHU Lille
Université de Lille
CHU Lille
Équipe(s) de recherche :
Nutritional modulation of inflammation and infection
Date de dépôt :
2019-03-01T15:24:45Z
2021-05-14T10:51:24Z
2022-06-29T07:34:57Z
2021-05-14T10:51:24Z
2022-06-29T07:34:57Z
Fichiers
- PreprintACIC2017.pdf
- Version finale acceptée pour publication (postprint)
- Accès restreint 2025-12-31
- Accéder au document