Title :

Ependymoma of the spinal cord in children. A retrospective french study

Author(s) :

Szathmari, Alexandru [Auteur]
Université Claude Bernard Lyon 1 [UCBL]
Zerah, Michel [Auteur]
CHU Necker - Enfants Malades [AP-HP]
Vinchon, Matthieu [Auteur]
Maladies Rares du Développement : Génétique, Régulation et Protéomique (RADEME) - ULR 7364
Maladies RAres du DÉveloppement embryonnaire et du Métabolisme : du phénotype au génotype et à la Fonction (RADEME) - ULR 7364
Dufour, Christelle [Auteur]
Institut Gustave Roussy [IGR]
Gimbert, Edouard [Auteur]
CHU de Bordeaux Pellegrin [Bordeaux]
Di Rocco, F. [Auteur]
Université Claude Bernard Lyon 1 [UCBL]
Chabaud, S. [Auteur]
Centre Léon Bérard [Lyon]
Conter, C. [Auteur]
Centre Léon Bérard [Lyon]
Mottolese, C. [Auteur]
Université Claude Bernard Lyon 1 [UCBL]
Frappaz, D. [Auteur]
Centre Léon Bérard [Lyon]

Journal title :

World neurosurgery

Abbreviated title :

World Neurosurg

Volume number :

126

Pages :

e1035-e1041

Publication date :

2019-03-12

ISSN :

1878-8769

Keyword(s) :

Radiation therapy
Spine surgery
Ependymoma in children

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

BACKGROUND: Ependymoma is the most frequent spinal tumor in adults but it is rather uncommon in children. The aim of the present study was to retrospectively summarize the clinical and therapeutic experience in the treatment ...
Show more >BACKGROUND: Ependymoma is the most frequent spinal tumor in adults but it is rather uncommon in children. The aim of the present study was to retrospectively summarize the clinical and therapeutic experience in the treatment of pediatric spinal ependymomas in France. METHODS: In the present retrospective multicenter study, data from patients aged <18 years who had been treated from 2000 to 2010 for spinal ependymomas were collected. Epidemiologic and tumor- and treatment-related data were analyzed. The prognostic factors for progression-free survival (PFS) were assessed. RESULTS: We identified 28 patients (22 males, 6 females). Their median age at surgery was 13.67 years (range, 0.7-17.6). Initial gross total resection (GTR) was achieved in 22 children and subtotal resection (STR) in 6. Histologically, 15 tumors were myxopapillary ependymomas and 11 were grade II and 2 grade III ependymomas. Adjuvant initial radiotherapy (RT) was performed in 6 patients. The median follow-up period was of 40 months (range, 2.3-127.5). The 5-year PFS rate was 51% (95% confidence interval, 26.3%-71.2%), and the overall survival rate was 100%. On univariate analysis, only GTR had a significant influence on PFS (P = 0.0013). A subgroup analysis showed a benefit of RT delivered to patients with GTR; however, RT failed to prevent relapse in the group with initial STR. CONCLUSIONS: Our data suggest that initial adjuvant RT might improve PFS after GTR but will not prevent relapse in patients with STR. Further studies are needed to define more specific treatments for the latter group.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille

Collections :

• Maladies Rares du Développement : Génétique, Régulation et Protéomique (RADEME) - ULR 7364

Submission date :

2021-09-02T07:02:02Z
2021-10-27T09:10:29Z