Immunoblot for the Diagnosis of Cutaneous ...
Type de document :
Article dans une revue scientifique
DOI :
URL permanente :
Titre :
Immunoblot for the Diagnosis of Cutaneous Leishmaniasis in French Guiana
Auteur(s) :
Menu, Estelle [Auteur]
Vecteurs - Infections tropicales et méditerranéennes [VITROME]
Blaizot, Romain [Auteur]
Mary, Charles [Auteur]
Vecteurs - Infections tropicales et méditerranéennes [VITROME]
Simon, Stéphane [Auteur]
Biome Tropical et Immuno-Pathophysiologie = Tropical Biome and ImmunoPhysiopathology [Lille] [TBIP]
Adenis, Antoine [Auteur]
Centre d'investigation clinique Antilles-Guyane [CIC - Antilles Guyane]
Blanchet, Denis [Auteur]
Biome Tropical et Immuno-Pathophysiologie = Tropical Biome and ImmunoPhysiopathology [Lille] [TBIP]
L’Ollivier, Coralie [Auteur]
Vecteurs - Infections tropicales et méditerranéennes [VITROME]
Ranque, Stéphane [Auteur]
Vecteurs - Infections tropicales et méditerranéennes [VITROME]
Demar, Magalie [Auteur]
Université de Guyane [UG]
Vecteurs - Infections tropicales et méditerranéennes [VITROME]
Blaizot, Romain [Auteur]
Mary, Charles [Auteur]
Vecteurs - Infections tropicales et méditerranéennes [VITROME]
Simon, Stéphane [Auteur]
Biome Tropical et Immuno-Pathophysiologie = Tropical Biome and ImmunoPhysiopathology [Lille] [TBIP]
Adenis, Antoine [Auteur]
Centre d'investigation clinique Antilles-Guyane [CIC - Antilles Guyane]
Blanchet, Denis [Auteur]
Biome Tropical et Immuno-Pathophysiologie = Tropical Biome and ImmunoPhysiopathology [Lille] [TBIP]
L’Ollivier, Coralie [Auteur]
Vecteurs - Infections tropicales et méditerranéennes [VITROME]
Ranque, Stéphane [Auteur]
Vecteurs - Infections tropicales et méditerranéennes [VITROME]
Demar, Magalie [Auteur]
Université de Guyane [UG]
Titre de la revue :
American Journal of Tropical Medicine and Hygiene
Pagination :
2091-2096
Éditeur :
American Society of Tropical Medicine and Hygiene
Date de publication :
2021-06-02
ISSN :
0002-9637
Discipline(s) HAL :
Sciences du Vivant [q-bio]/Microbiologie et Parasitologie/Bactériologie
Sciences du Vivant [q-bio]/Microbiologie et Parasitologie/Virologie
Sciences du Vivant [q-bio]/Microbiologie et Parasitologie/Parasitologie
Sciences du Vivant [q-bio]/Médecine humaine et pathologie/Cardiologie et système cardiovasculaire
Sciences du Vivant [q-bio]/Médecine humaine et pathologie/Maladies émergentes
Sciences du Vivant [q-bio]/Médecine humaine et pathologie/Maladies infectieuses
Sciences du Vivant [q-bio]/Microbiologie et Parasitologie/Virologie
Sciences du Vivant [q-bio]/Microbiologie et Parasitologie/Parasitologie
Sciences du Vivant [q-bio]/Médecine humaine et pathologie/Cardiologie et système cardiovasculaire
Sciences du Vivant [q-bio]/Médecine humaine et pathologie/Maladies émergentes
Sciences du Vivant [q-bio]/Médecine humaine et pathologie/Maladies infectieuses
Résumé en anglais : [en]
Abstract. Cutaneous leishmaniasis (CL) is firmly established in South America. We aimed to assess the detection of IgG antibodies against 14 and/or 16 kDa antigens by immunoblot (IB) for CL serological diagnosis in French ...
Lire la suite >Abstract. Cutaneous leishmaniasis (CL) is firmly established in South America. We aimed to assess the detection of IgG antibodies against 14 and/or 16 kDa antigens by immunoblot (IB) for CL serological diagnosis in French Guiana, an area where many endemic pathogens could interfere with it. This study was performed retrospectively on sera from 141 patients at the Cayenne tertiary hospital: 30 were patients with confirmed CL, 71 were diagnosed with various other endemic pathogens, 11 were diagnosed with an autoimmune disease, and 29 controls had no history of CL. Antibodies bound to the 14 and/or 16 kDa antigens in 27 of the 30 CL patients’ sera and in 39 of the 111 non-CL patients’ sera (26 from the infectious diseases group, four from the autoimmune diseases group, and nine from the dermatology department). The method tested showed a high sensitivity (90%) and a low specificity (66%), and a diagnosis odds ratio of 17.5 (95% CI [4.6–78.0]). This IB may be helpful to exclude the diagnosis of CL, prompting physicians to look for another diagnosis in the case of a negative IB.Lire moins >
Lire la suite >Abstract. Cutaneous leishmaniasis (CL) is firmly established in South America. We aimed to assess the detection of IgG antibodies against 14 and/or 16 kDa antigens by immunoblot (IB) for CL serological diagnosis in French Guiana, an area where many endemic pathogens could interfere with it. This study was performed retrospectively on sera from 141 patients at the Cayenne tertiary hospital: 30 were patients with confirmed CL, 71 were diagnosed with various other endemic pathogens, 11 were diagnosed with an autoimmune disease, and 29 controls had no history of CL. Antibodies bound to the 14 and/or 16 kDa antigens in 27 of the 30 CL patients’ sera and in 39 of the 111 non-CL patients’ sera (26 from the infectious diseases group, four from the autoimmune diseases group, and nine from the dermatology department). The method tested showed a high sensitivity (90%) and a low specificity (66%), and a diagnosis odds ratio of 17.5 (95% CI [4.6–78.0]). This IB may be helpful to exclude the diagnosis of CL, prompting physicians to look for another diagnosis in the case of a negative IB.Lire moins >
Langue :
Anglais
Comité de lecture :
Oui
Audience :
Internationale
Vulgarisation :
Non
Source :
Date de dépôt :
2021-09-05T01:30:58Z
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