Immunoblot for the Diagnosis of Cutaneous ...
Document type :
Article dans une revue scientifique
DOI :
Permalink :
Title :
Immunoblot for the Diagnosis of Cutaneous Leishmaniasis in French Guiana
Author(s) :
Menu, Estelle [Auteur]
Vecteurs - Infections tropicales et méditerranéennes [VITROME]
Blaizot, Romain [Auteur]
Mary, Charles [Auteur]
Vecteurs - Infections tropicales et méditerranéennes [VITROME]
Simon, Stéphane [Auteur]
Biomes Tropicaux et Immuno-Pathophysiologie = Tropical Biome and ImmunoPhysiopathology [Lille] [TBIP]
Adenis, Antoine [Auteur]
Centre d'investigation clinique Antilles-Guyane [CIC - Antilles Guyane]
Blanchet, Denis [Auteur]
Biomes Tropicaux et Immuno-Pathophysiologie = Tropical Biome and ImmunoPhysiopathology [Lille] [TBIP]
L’Ollivier, Coralie [Auteur]
Vecteurs - Infections tropicales et méditerranéennes [VITROME]
Ranque, Stéphane [Auteur]
Vecteurs - Infections tropicales et méditerranéennes [VITROME]
Demar, Magalie [Auteur]
Université de Guyane [UG]
Vecteurs - Infections tropicales et méditerranéennes [VITROME]
Blaizot, Romain [Auteur]
Mary, Charles [Auteur]
Vecteurs - Infections tropicales et méditerranéennes [VITROME]
Simon, Stéphane [Auteur]
Biomes Tropicaux et Immuno-Pathophysiologie = Tropical Biome and ImmunoPhysiopathology [Lille] [TBIP]
Adenis, Antoine [Auteur]
Centre d'investigation clinique Antilles-Guyane [CIC - Antilles Guyane]
Blanchet, Denis [Auteur]
Biomes Tropicaux et Immuno-Pathophysiologie = Tropical Biome and ImmunoPhysiopathology [Lille] [TBIP]
L’Ollivier, Coralie [Auteur]
Vecteurs - Infections tropicales et méditerranéennes [VITROME]
Ranque, Stéphane [Auteur]
Vecteurs - Infections tropicales et méditerranéennes [VITROME]
Demar, Magalie [Auteur]

Université de Guyane [UG]
Journal title :
American Journal of Tropical Medicine and Hygiene
Pages :
2091-2096
Publisher :
American Society of Tropical Medicine and Hygiene
Publication date :
2021-06-02
ISSN :
0002-9637
HAL domain(s) :
Sciences du Vivant [q-bio]/Microbiologie et Parasitologie/Bactériologie
Sciences du Vivant [q-bio]/Microbiologie et Parasitologie/Virologie
Sciences du Vivant [q-bio]/Microbiologie et Parasitologie/Parasitologie
Sciences du Vivant [q-bio]/Médecine humaine et pathologie/Cardiologie et système cardiovasculaire
Sciences du Vivant [q-bio]/Médecine humaine et pathologie/Maladies émergentes
Sciences du Vivant [q-bio]/Médecine humaine et pathologie/Maladies infectieuses
Sciences du Vivant [q-bio]/Microbiologie et Parasitologie/Virologie
Sciences du Vivant [q-bio]/Microbiologie et Parasitologie/Parasitologie
Sciences du Vivant [q-bio]/Médecine humaine et pathologie/Cardiologie et système cardiovasculaire
Sciences du Vivant [q-bio]/Médecine humaine et pathologie/Maladies émergentes
Sciences du Vivant [q-bio]/Médecine humaine et pathologie/Maladies infectieuses
English abstract : [en]
Abstract. Cutaneous leishmaniasis (CL) is firmly established in South America. We aimed to assess the detection of IgG antibodies against 14 and/or 16 kDa antigens by immunoblot (IB) for CL serological diagnosis in French ...
Show more >Abstract. Cutaneous leishmaniasis (CL) is firmly established in South America. We aimed to assess the detection of IgG antibodies against 14 and/or 16 kDa antigens by immunoblot (IB) for CL serological diagnosis in French Guiana, an area where many endemic pathogens could interfere with it. This study was performed retrospectively on sera from 141 patients at the Cayenne tertiary hospital: 30 were patients with confirmed CL, 71 were diagnosed with various other endemic pathogens, 11 were diagnosed with an autoimmune disease, and 29 controls had no history of CL. Antibodies bound to the 14 and/or 16 kDa antigens in 27 of the 30 CL patients’ sera and in 39 of the 111 non-CL patients’ sera (26 from the infectious diseases group, four from the autoimmune diseases group, and nine from the dermatology department). The method tested showed a high sensitivity (90%) and a low specificity (66%), and a diagnosis odds ratio of 17.5 (95% CI [4.6–78.0]). This IB may be helpful to exclude the diagnosis of CL, prompting physicians to look for another diagnosis in the case of a negative IB.Show less >
Show more >Abstract. Cutaneous leishmaniasis (CL) is firmly established in South America. We aimed to assess the detection of IgG antibodies against 14 and/or 16 kDa antigens by immunoblot (IB) for CL serological diagnosis in French Guiana, an area where many endemic pathogens could interfere with it. This study was performed retrospectively on sera from 141 patients at the Cayenne tertiary hospital: 30 were patients with confirmed CL, 71 were diagnosed with various other endemic pathogens, 11 were diagnosed with an autoimmune disease, and 29 controls had no history of CL. Antibodies bound to the 14 and/or 16 kDa antigens in 27 of the 30 CL patients’ sera and in 39 of the 111 non-CL patients’ sera (26 from the infectious diseases group, four from the autoimmune diseases group, and nine from the dermatology department). The method tested showed a high sensitivity (90%) and a low specificity (66%), and a diagnosis odds ratio of 17.5 (95% CI [4.6–78.0]). This IB may be helpful to exclude the diagnosis of CL, prompting physicians to look for another diagnosis in the case of a negative IB.Show less >
Language :
Anglais
Peer reviewed article :
Oui
Audience :
Internationale
Popular science :
Non
Source :
Submission date :
2021-09-05T01:30:58Z
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