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Influenza A Virus Infection Induces White ...
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Document type :
Article dans une revue scientifique
DOI :
10.33696/immunology.2.055
Title :
Influenza A Virus Infection Induces White Adipose Tissue Browning: A Metabolic Adaptation to Infection?
Author(s) :
Barthelemy, Johanna [Auteur]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Wolowczuk, Isabelle [Auteur correspondant]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Journal title :
Journal of Cellular Immunology
Pages :
276-283
Publisher :
Scientific Archives
Publication date :
2020
ISSN :
2689-2812
English keyword(s) :
Adipose tissue
Browning
Influenza A virus
HAL domain(s) :
Sciences du Vivant [q-bio]/Médecine humaine et pathologie/Maladies infectieuses
Sciences du Vivant [q-bio]/Médecine humaine et pathologie/Anatomie, Histologie, Anatomopathologie [q-bio.TO]
English abstract : [en]
We recently reported that influenza infection is associated with drastic, depot-specific changes in white adipose tissue (WAT), notably the occurrence of thermogenic brown-like adipocytes within the subcutaneous depot, a ...
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We recently reported that influenza infection is associated with drastic, depot-specific changes in white adipose tissue (WAT), notably the occurrence of thermogenic brown-like adipocytes within the subcutaneous depot, a process referred to as WAT browning. In mammals, induction of the thermogenic circuit increases heat production and consumes energy, consequently improving host’s metabolism. Importantly, we also demonstrated that mouse and human preadipocytes commit to the thermogenic differentiation program upon in vitro influenza virus infection; this signifies that infection-associated WAT browning may partly rely on a direct effect of the virus on fat.Herein, after a short review of the physiological and cellular mechanisms that have been described to regulate WAT browning, including immune-cell-dependent ones, we will comment on the role that white adipose tissue, which is at the crossroads of metabolism and immunity, may play in influenza pathophysiology.Show less >
Language :
Anglais
Peer reviewed article :
Oui
Audience :
Internationale
Popular science :
Non
Collections :
  • Centre d'Infection et d'Immunité de Lille (CIIL) - U1019 - UMR 9017
Source :
Harvested from HAL
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