New injectable self-assembled hydrogels ...
Type de document :
Article dans une revue scientifique: Article original
URL permanente :
Titre :
New injectable self-assembled hydrogels that promote angiogenesis through a bioactive degradation product
Auteur(s) :
Sindhu, Kotagudda Ranganath [Auteur]
Médicaments et biomatériaux à libération contrôlée: mécanismes et optimisation - Advanced Drug Delivery Systems - U 1008 [MBLC - ADDS]
Bioingénierie tissulaire [BIOTIS]
Bansode, Nitin D. [Auteur]
Ecole Nationale Supérieure de Chimie, de Biologie et de Physique (ENSCBP)
Acides Nucléiques : Régulations Naturelle et Artificielle [ARNA]
Rémy, Murielle [Auteur]
Bioingénierie tissulaire [BIOTIS]
Morel, Chloé [Auteur]
Bioingénierie tissulaire [BIOTIS]
Bareille, Reine [Auteur]
Bioingénierie tissulaire [BIOTIS]
Hagedorn, Martin [Auteur]
Biothérapies des maladies génétiques et cancers
Hinz, Boris [Auteur]
University of Toronto
Barthélémy, Philippe A. [Auteur]
Acides Nucléiques : Régulations Naturelle et Artificielle [ARNA]
Chassande, Olivier [Auteur]
Bioingénierie tissulaire [BIOTIS]
Boiziau, Claudine [Auteur]
Bioingénierie tissulaire [BIOTIS]
Médicaments et biomatériaux à libération contrôlée: mécanismes et optimisation - Advanced Drug Delivery Systems - U 1008 [MBLC - ADDS]
Bioingénierie tissulaire [BIOTIS]
Bansode, Nitin D. [Auteur]
Ecole Nationale Supérieure de Chimie, de Biologie et de Physique (ENSCBP)
Acides Nucléiques : Régulations Naturelle et Artificielle [ARNA]
Rémy, Murielle [Auteur]
Bioingénierie tissulaire [BIOTIS]
Morel, Chloé [Auteur]
Bioingénierie tissulaire [BIOTIS]
Bareille, Reine [Auteur]
Bioingénierie tissulaire [BIOTIS]
Hagedorn, Martin [Auteur]
Biothérapies des maladies génétiques et cancers
Hinz, Boris [Auteur]
University of Toronto
Barthélémy, Philippe A. [Auteur]
Acides Nucléiques : Régulations Naturelle et Artificielle [ARNA]
Chassande, Olivier [Auteur]
Bioingénierie tissulaire [BIOTIS]
Boiziau, Claudine [Auteur]
Bioingénierie tissulaire [BIOTIS]
Titre de la revue :
Acta Biomaterialia
Nom court de la revue :
Acta Biomaterialia
Numéro :
115
Pagination :
197-209
Date de publication :
2020-10
ISSN :
17427061
Résumé en anglais : [en]
Hydrogels used in regenerative medicine are often designed to allow cellular infiltration, degradation, and neovascularization. Low molecular weight hydrogels (LMWHs), formed by self-assembly via non-covalent interactions, ...
Lire la suite >Hydrogels used in regenerative medicine are often designed to allow cellular infiltration, degradation, and neovascularization. Low molecular weight hydrogels (LMWHs), formed by self-assembly via non-covalent interactions, are gaining significant interest because they are soft, easy to use and injectable. We propose LMWHs as suitable body implant materials that can stimulate tissue regeneration. We produced four new LMWHs with molecular entities containing nucleic acid and lipid building blocks and analyzed the foreign body response upon subcutaneous implantation into mice. Despite being infiltrated with macrophages, none of the hydrogels triggered detrimental inflammatory responses. Most macrophages present in the hydrogel-surrounding tissue acquired an immuno-modulatory rather than inflammatory phenotype. Concomitantly, no fibrotic capsule was formed after three weeks. Our glyconucleolipid LMWHs exhibited different degradation kinetics in vivo and in vitro. LMWHs with high angiogenic properties in vivo, were found to release glyconucleoside (glucose covalently linked to thymidine via a triazole moiety) as a common by-product of in vitro LMWH degradation. Chemically synthesized glyconucleoside exhibited angiogenic properties in vitro in scratch assays with monolayers of human endothelial cells and in vivo using the chick chorioallantoic membrane assay. Collectively, LMWHs hold promise as efficient scaffolds for various regenerative applications by displaying good biointegration without causing fibrosis, and by promoting angiogenesis through the release of a pro-angiogenic degradation product.Lire moins >
Lire la suite >Hydrogels used in regenerative medicine are often designed to allow cellular infiltration, degradation, and neovascularization. Low molecular weight hydrogels (LMWHs), formed by self-assembly via non-covalent interactions, are gaining significant interest because they are soft, easy to use and injectable. We propose LMWHs as suitable body implant materials that can stimulate tissue regeneration. We produced four new LMWHs with molecular entities containing nucleic acid and lipid building blocks and analyzed the foreign body response upon subcutaneous implantation into mice. Despite being infiltrated with macrophages, none of the hydrogels triggered detrimental inflammatory responses. Most macrophages present in the hydrogel-surrounding tissue acquired an immuno-modulatory rather than inflammatory phenotype. Concomitantly, no fibrotic capsule was formed after three weeks. Our glyconucleolipid LMWHs exhibited different degradation kinetics in vivo and in vitro. LMWHs with high angiogenic properties in vivo, were found to release glyconucleoside (glucose covalently linked to thymidine via a triazole moiety) as a common by-product of in vitro LMWH degradation. Chemically synthesized glyconucleoside exhibited angiogenic properties in vitro in scratch assays with monolayers of human endothelial cells and in vivo using the chick chorioallantoic membrane assay. Collectively, LMWHs hold promise as efficient scaffolds for various regenerative applications by displaying good biointegration without causing fibrosis, and by promoting angiogenesis through the release of a pro-angiogenic degradation product.Lire moins >
Langue :
Anglais
Audience :
Non spécifiée
Vulgarisation :
Non
Établissement(s) :
Inserm
Université de Lille
CHU Lille
Université de Lille
CHU Lille
Collections :
Date de dépôt :
2021-12-08T09:53:05Z
2024-02-20T12:12:55Z
2024-02-20T12:14:44Z
2024-02-20T12:12:55Z
2024-02-20T12:14:44Z
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