An Intimate Relationship That Deserves Further Scrutiny
Document type :
Article dans une revue scientifique: Article original
DOI :
PMID :
Title :
Toxoplasma and Dendritic Cells
An Intimate Relationship That Deserves Further Scrutiny
An Intimate Relationship That Deserves Further Scrutiny
Author(s) :
Poncet, Anaïs F. [Auteur]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Blanchard, Nicolas [Auteur correspondant]
Centre de Physiopathologie Toulouse Purpan [CPTP]
Marion, Sabrina [Auteur correspondant]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Blanchard, Nicolas [Auteur correspondant]
Centre de Physiopathologie Toulouse Purpan [CPTP]
Marion, Sabrina [Auteur correspondant]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Journal title :
Trends in parasitology
Pages :
870 - 886
Publisher :
Elsevier
Publication date :
2019-11-30
ISSN :
1471-4922
English keyword(s) :
Toxoplasma gondii
antigen presentation
dendritic cells
innate sensing
migration
antigen presentation
dendritic cells
innate sensing
migration
HAL domain(s) :
Sciences du Vivant [q-bio]
English abstract : [en]
Toxoplasma gondii (Tg), an obligate intracellular parasite of the phylum Apicomplexa, infects a wide range of animals, including humans. A hallmark of Tg infection is the subversion of host responses, which is thought to ...
Show more >Toxoplasma gondii (Tg), an obligate intracellular parasite of the phylum Apicomplexa, infects a wide range of animals, including humans. A hallmark of Tg infection is the subversion of host responses, which is thought to favor parasite persistence and propagation to new hosts. Recently, a variety of parasite-secreted modulatory effectors have been uncovered in fibroblasts and macrophages, but the specific interplay between Tg and dendritic cells (DCs) is just beginning to emerge. In this review, we summarize the current knowledge on Tg-DC interactions, including innate recognition, cytokine production, and antigen presentation, and discuss open questions regarding how Tg-secreted effectors may shape DC functions to perturb innate and adaptive immunity.Show less >
Show more >Toxoplasma gondii (Tg), an obligate intracellular parasite of the phylum Apicomplexa, infects a wide range of animals, including humans. A hallmark of Tg infection is the subversion of host responses, which is thought to favor parasite persistence and propagation to new hosts. Recently, a variety of parasite-secreted modulatory effectors have been uncovered in fibroblasts and macrophages, but the specific interplay between Tg and dendritic cells (DCs) is just beginning to emerge. In this review, we summarize the current knowledge on Tg-DC interactions, including innate recognition, cytokine production, and antigen presentation, and discuss open questions regarding how Tg-secreted effectors may shape DC functions to perturb innate and adaptive immunity.Show less >
Language :
Anglais
Peer reviewed article :
Oui
Audience :
Internationale
Popular science :
Non
Source :
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