Toxoplasma and Dendritic Cells

Poncet, Anaïs F.; Blanchard, Nicolas; MARION, Sabrina

An Intimate Relationship That Deserves Further Scrutiny

Document type :

Article dans une revue scientifique

DOI :

10.1016/j.pt.2019.08.001

PMID :

31492624

Title :

Toxoplasma and Dendritic Cells
An Intimate Relationship That Deserves Further Scrutiny

Author(s) :

Poncet, Anaïs F. [Auteur]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Blanchard, Nicolas [Auteur correspondant]
Centre de Physiopathologie Toulouse Purpan [CPTP]
MARION, Sabrina [Auteur correspondant]

Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]

Journal title :

Trends in parasitology

Pages :

870 - 886

Publisher :

Elsevier

Publication date :

2019-11-30

ISSN :

1471-4922

English keyword(s) :

Toxoplasma gondii
antigen presentation
dendritic cells
innate sensing
migration

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Toxoplasma gondii (Tg), an obligate intracellular parasite of the phylum Apicomplexa, infects a wide range of animals, including humans. A hallmark of Tg infection is the subversion of host responses, which is thought to ...
Show more >Toxoplasma gondii (Tg), an obligate intracellular parasite of the phylum Apicomplexa, infects a wide range of animals, including humans. A hallmark of Tg infection is the subversion of host responses, which is thought to favor parasite persistence and propagation to new hosts. Recently, a variety of parasite-secreted modulatory effectors have been uncovered in fibroblasts and macrophages, but the specific interplay between Tg and dendritic cells (DCs) is just beginning to emerge. In this review, we summarize the current knowledge on Tg-DC interactions, including innate recognition, cytokine production, and antigen presentation, and discuss open questions regarding how Tg-secreted effectors may shape DC functions to perturb innate and adaptive immunity.Show less >

Language :

Anglais

Peer reviewed article :

Oui

Audience :

Internationale

Popular science :

Non

Collections :