Title :

Clinical practice of rTMS reveals a functional dissociation between agency and hallucinations in schizophrenia

Author(s) :

Jardri, Renaud [Auteur correspondant]
Laboratoire de Neurosciences Fonctionnelles et Pathologies [LNFP]
Delevoye, Yvonne [Auteur]
Unité de Recherche en Sciences Cognitives et Affectives [URECA]
Unité de Recherche en Sciences Cognitives et Affectives [URECA]
Lucas, Bernard [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Pins, Delphine [Auteur]
Laboratoire de Neurosciences Fonctionnelles et Pathologies [LNFP]
Bulot, Virginie [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Delmaire, Christine [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Thomas, Pierre [Auteur]
Laboratoire de Neurosciences Fonctionnelles et Pathologies [LNFP]
Delion, Pierre [Auteur]
Laboratoire de Neurosciences Fonctionnelles et Pathologies [LNFP]
Goeb, Jean-Louis [Auteur]
Laboratoire de Neurosciences Fonctionnelles et Pathologies [LNFP]

Journal title :

Neuropsychologia

Abbreviated title :

Neuropsychologia

Volume number :

47

Pages :

132-138

Publisher :

Elsevier BV

Publication date :

2009-01

ISSN :

0028-3932

English keyword(s) :

self-awareness
agency
hallucinations
schizophrenia
motor control
rTMS
fMRI

English abstract : [en]

We report here the case of a hospitalized 11 year-old boy (YP) with a positive diagnosis of ‘Childhood Onset Schizophrenia’. YP experienced verbal-auditory hallucinations, a delusion of alien control and hetero-aggressive ...
Show more >We report here the case of a hospitalized 11 year-old boy (YP) with a positive diagnosis of ‘Childhood Onset Schizophrenia’. YP experienced verbal-auditory hallucinations, a delusion of alien control and hetero-aggressive behaviour. Antipsychotic drugs were unsuccessful and furthermore provoked severe acute dystonia. fMRI-guided rTMS applied over several cortical regions provided the means to reveal for the first time a functional dissociation between auditory-verbal hallucinations and agency. These results demonstrate the efficacy of rTMS for young patients suffering from drug-resistant hallucinations but they furthermore question the physiopathology of the hallucinatory process by suggesting that agency and hallucinations may be sub-served by different neural networks.Show less >

Language :

Anglais

Peer reviewed article :

Oui

Audience :

Internationale

Administrative institution(s) :

Université de Lille
CNRS
CHU Lille

Collections :

• Autres travaux scientifiques

Submission date :

2022-01-05T16:31:03Z
2022-01-07T12:19:30Z