Non-coding rnas as new therapeutic targets ...
Document type :
Article dans une revue scientifique: Article de synthèse/Review paper
DOI :
PMID :
Permalink :
Title :
Non-coding rnas as new therapeutic targets in the context of renal fibrosis
Author(s) :
Van Der Hauwaert, Cynthia [Auteur]
IMPact de l'Environnement Chimique sur la Santé humaine (IMPECS) - EA 4483
Glowacki, Francois [Auteur]
Impact de l'environnement chimique sur la santé humaine - ULR 4483 [IMPECS]
IMPact de l'Environnement Chimique sur la Santé humaine (IMPECS) - EA 4483
Pottier, Nicolas [Auteur]
IMPact de l'Environnement Chimique sur la Santé humaine (IMPECS) - EA 4483
Cauffiez, Christelle [Auteur]
IMPact de l'Environnement Chimique sur la Santé humaine (IMPECS) - EA 4483

IMPact de l'Environnement Chimique sur la Santé humaine (IMPECS) - EA 4483
Glowacki, Francois [Auteur]

Impact de l'environnement chimique sur la santé humaine - ULR 4483 [IMPECS]
IMPact de l'Environnement Chimique sur la Santé humaine (IMPECS) - EA 4483
Pottier, Nicolas [Auteur]

IMPact de l'Environnement Chimique sur la Santé humaine (IMPECS) - EA 4483
Cauffiez, Christelle [Auteur]

IMPact de l'Environnement Chimique sur la Santé humaine (IMPECS) - EA 4483
Journal title :
International Journal of Molecular Sciences
Abbreviated title :
Int J Mol Sci
Volume number :
20
Pages :
1977
Publication date :
2019-04-23
ISSN :
1661-6596
Keyword(s) :
renal fibrosis
non-coding RNAs
microRNAs
long non-coding RNAs
biomarkers
therapeutics targets
non-coding RNAs
microRNAs
long non-coding RNAs
biomarkers
therapeutics targets
HAL domain(s) :
Sciences du Vivant [q-bio]
English abstract : [en]
Fibrosis, or tissue scarring, is defined as the excessive, persistent and destructive accumulation of extracellular matrix components in response to chronic tissue injury. Renal fibrosis represents the final stage of most ...
Show more >Fibrosis, or tissue scarring, is defined as the excessive, persistent and destructive accumulation of extracellular matrix components in response to chronic tissue injury. Renal fibrosis represents the final stage of most chronic kidney diseases and contributes to the progressive and irreversible decline in kidney function. Limited therapeutic options are available and the molecular mechanisms governing the renal fibrosis process are complex and remain poorly understood. Recently, the role of non-coding RNAs, and in particular microRNAs (miRNAs), has been described in kidney fibrosis. Seminal studies have highlighted their potential importance as new therapeutic targets and innovative diagnostic and/or prognostic biomarkers. This review will summarize recent scientific advances and will discuss potential clinical applications as well as future research directions.Show less >
Show more >Fibrosis, or tissue scarring, is defined as the excessive, persistent and destructive accumulation of extracellular matrix components in response to chronic tissue injury. Renal fibrosis represents the final stage of most chronic kidney diseases and contributes to the progressive and irreversible decline in kidney function. Limited therapeutic options are available and the molecular mechanisms governing the renal fibrosis process are complex and remain poorly understood. Recently, the role of non-coding RNAs, and in particular microRNAs (miRNAs), has been described in kidney fibrosis. Seminal studies have highlighted their potential importance as new therapeutic targets and innovative diagnostic and/or prognostic biomarkers. This review will summarize recent scientific advances and will discuss potential clinical applications as well as future research directions.Show less >
Language :
Anglais
Audience :
Internationale
Popular science :
Non
Administrative institution(s) :
CNRS
Université de Lille
Université de Lille
Collections :
Submission date :
2022-02-02T10:24:00Z
2022-11-09T08:14:49Z
2023-01-11T08:37:57Z
2022-11-09T08:14:49Z
2023-01-11T08:37:57Z
Files
- ijms-20-01977.pdf
- Version éditeur
- Open access
- Access the document