Title :

Trinuclear ni(ii), pd(ii) and cu(ii) complexes containing the 2-hydroxy-benzaldehyde-ferrocenyl-sulfonylhydrazone ligand: synthesis, structural characterization and antiplasmodial evaluation

Author(s) :

Almendras, Ignacio [Auteur]
Huentupil, Yosselin [Auteur]
Novoa, Nestor [Auteur]
Roussel, Pascal [Auteur]
Melis, Diana R. [Auteur]
Smith, Gregory S. [Auteur]
Arancibia, Rodrigo [Auteur]

Journal title :

Inorganica chimica acta

Abbreviated title :

Inorg. Chim. Acta

Volume number :

496

Publication date :

2019-10-01

ISSN :

0020-1693

English keyword(s) :

Trinuclear complexes
Ferrocenyl-sulfonylhydrazone ligand
Antiplasmodial

HAL domain(s) :

Chimie/Chimie inorganique

English abstract : [en]

The novel 2-hydroxy-benzaldehyde-ferrocenyl-sulfonylhydrazone ligand [(η5-C5H5)Fe(η5-C5H4SO2NH-Ndouble bondCH-C6H4-2-OH)] (HL) and its nickel(II), palladium(II) and copper(II) complexes (1a–c) have been synthesized. All ...
Show more >The novel 2-hydroxy-benzaldehyde-ferrocenyl-sulfonylhydrazone ligand [(η5-C5H5)Fe(η5-C5H4SO2NH-Ndouble bondCH-C6H4-2-OH)] (HL) and its nickel(II), palladium(II) and copper(II) complexes (1a–c) have been synthesized. All compounds were characterized using conventional spectroscopic and analytical techniques (infrared, 1H and 13C NMR, mass spectrometry and elemental analysis). The proposed molecular structures of HL, 1a and 1c were confirmed by single-crystal X-ray crystallography. The in vitro antiplasmodial activity of the new ligand and its corresponding metal complexes was evaluated against the chloroquine-sensitive (NF54) strain of the human malaria parasite, Plasmodium falciparum, and showed only modest activities in the micromolar range.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

CNRS
Centrale Lille
ENSCL
Univ. Artois
Université de Lille

Collections :

• Unité de Catalyse et Chimie du Solide (UCCS) - UMR 8181

Research team(s) :

Matériaux inorganiques, structures, systèmes et propriétés (MISSP)

Submission date :

2022-03-02T07:14:05Z