Title :

Chemical structure and biological activity of a highly branched (1 → 3,1 → 6)- _-d-glucan from Isochrysis galbanaIrina.

Author(s) :

Sadovskaya, Irina [Auteur]
Université du Littoral Côte d'Opale [ULCO]
Souissi, Anissa [Auteur]
Laboratoire d’Océanologie et de Géosciences (LOG) - UMR 8187 [LOG]
SOUISSI, Sami [Auteur]
Laboratoire d’Océanologie et de Géosciences (LOG) - UMR 8187 [LOG]
Grard, Thierry [Auteur]
Université du Littoral Côte d'Opale [ULCO]
Lencel, Philippe [Auteur]
Université du Littoral Côte d'Opale [ULCO]
M. Greene, Catherine [Auteur]
Duin, Sarah [Auteur]
Dmitrenok, Pavel S. [Auteur]
Chizhov, Alexander O. [Auteur]
Shashkov, Alexander S. [Auteur]
Usov, Anatolii I. [Auteur]

Journal title :

Carbohydrate Polymers

Pages :

139-148

Publisher :

Elsevier

Publication date :

2014

ISSN :

0144-8617

HAL domain(s) :

Planète et Univers [physics]/Sciences de la Terre/Océanographie

English abstract : [en]

tA highly branched (1 → 3,1 → 6)- -d-glucan was isolated from the microalga Isochrysis galbana Parke(Isochrysidales, Haptophyta). The polysaccharide structure was analyzed by methylation and Smithdegradation, as well as ...
Show more >tA highly branched (1 → 3,1 → 6)- -d-glucan was isolated from the microalga Isochrysis galbana Parke(Isochrysidales, Haptophyta). The polysaccharide structure was analyzed by methylation and Smithdegradation, as well as by ESI and MALDI TOF mass spectrometry and NMR spectroscopy. The glucanwas shown to contain a (1 → 6)-linked backbone, where every residue is substituted at position 3 byGlc, which in turn may be substituted at C-6 by a single Glc or by rather short (up to tetrasaccharide)oligosaccharide chains. All the 3-linked Glc residues are present in these side chains. In the biologicalactivity experiments it was demonstrated that the polysaccharide directly inhibits the proliferation ofU937 human leukemic monocyte lymphoma cells and therefore has potential anti-tumor activity.Show less >

Language :

Anglais

Peer reviewed article :

Oui

Audience :

Internationale

Popular science :

Non

Collections :

• Laboratoire d'Océanologie et de Géosciences (LOG) - UMR 8187

Source :

Harvested from HAL