Title :

Whole and fractionated human platelet lysate biomaterials-based biotherapy induces strong neuroprotection in experimental models of amyotrophic lateral sclerosis

Author(s) :

Gouel, Flore [Auteur]
Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer - U837 [JPArc]
Timmerman, Kelly [Auteur]
Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer - U837 [JPArc]
Gosset, Philippe [Auteur]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Raoul, Cedric [Auteur]
Institut des Neurosciences de Montpellier [INM]
Dutheil, Mary [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Jonneaux, Aurelie [Auteur]
Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer - U837 [JPArc]
Garcon, Guillaume [Auteur]
Impact de l'environnement chimique sur la santé humaine - ULR 4483 [IMPECS]
Moreau, caroline [Auteur]
Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer - U837 [JPArc]
Danel-Brunaud, Veronique [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Duce, James A. [Auteur]
University of Cambridge [UK] [CAM]
Burnouf, Thierry [Auteur]
Taipei Medical University
Devedjian, Jean-Christophe [Auteur]
Lille Neurosciences & Cognition - U 1172 [LilNCog]
Devos, David [Auteur]
Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer - U837 [JPArc]

Journal title :

Biomaterials

Pages :

121311

Publisher :

Elsevier

Publication date :

2021

ISSN :

1878-5905

English keyword(s) :

Platelet biomaterials
Neuroprotection
Amyotrophic lateral sclerosis
Motoneuron
Neurodegenerative diseases
Neurotrophic growth factors

HAL domain(s) :

Sciences du Vivant [q-bio]/Neurosciences [q-bio.NC]/Neurobiologie
Sciences du Vivant [q-bio]/Ingénierie biomédicale/Biomatériaux

English abstract : [en]

Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease of motor neurons leading to death within 3 years and without a curative treatment. Neurotrophic growth factors (NTFs) are pivotal for cell ...
Show more >Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease of motor neurons leading to death within 3 years and without a curative treatment. Neurotrophic growth factors (NTFs) are pivotal for cell survival. A reason for the lack of patient efficacy with single recombinant NTF brain infusion is likely to be due to the synergistic neuroprotective action of multiple NTFs on a diverse set of signaling pathways. Fractionated (protein size <50, <30, <10, <3 kDa) heat-treated human platelet lysate (HHPL) preparations were adapted for use in brain tissue with the aim of demonstrating therapeutic value in ALS models and further elucidation of the mechanisms of action. In neuronal culture all fractions induced Akt-dependent neuroprotection as well as a strong anti-apoptotic and anti-ferroptotic action. In the <3 kDa fraction anti-ferroptotic properties were shown to be GPX4 dependent highlighting a role for other platelet elements associated with NTFs. In the SOD1G86RShow less >

Language :

Anglais

Peer reviewed article :

Oui

Audience :

Internationale

Popular science :

Non

ANR Project :

SATT NORD

Collections :

• Centre d'Infection et d'Immunité de Lille (CIIL) - U1019 - UMR 9017

Source :

Harvested from HAL