Unexpected Association of Desacyl-Ghrelin ...
Type de document :
Article dans une revue scientifique: Article original
PMID :
URL permanente :
Titre :
Unexpected Association of Desacyl-Ghrelin with Physical Activity and Chronic Food Restriction: A Translational Study on Anorexia Nervosa.
Auteur(s) :
Duriez, Philibert [Auteur]
Robichon, Lauralee [Auteur]
Dardennes, Roland [Auteur]
Lavoisy, Guillaume [Auteur]
Grouselle, Dominique [Auteur]
Epelbaum, Jacques [Auteur]
Ramoz, Nicolas [Auteur]
Gorwood, Philip [Auteur]
Tolle, Virginie [Auteur]
Viltart, Odile [Auteur]
Institut de psychiatrie et neurosciences de Paris [IPNP - U1266 Inserm - Paris Descartes]
Robichon, Lauralee [Auteur]
Dardennes, Roland [Auteur]
Lavoisy, Guillaume [Auteur]
Grouselle, Dominique [Auteur]
Epelbaum, Jacques [Auteur]
Ramoz, Nicolas [Auteur]
Gorwood, Philip [Auteur]
Tolle, Virginie [Auteur]
Viltart, Odile [Auteur]
Institut de psychiatrie et neurosciences de Paris [IPNP - U1266 Inserm - Paris Descartes]
Titre de la revue :
JOURNAL OF CLINICAL MEDICINE
Nom court de la revue :
J Clin Med
Numéro :
9
Date de publication :
2020-08-28
ISSN :
2077-0383
Mot(s)-clé(s) en anglais :
acyl-ghrelin
animal models
chronic food restriction
desacyl-ghrelin
physical activity
restrictive anorexia nervosa
weight recovery
animal models
chronic food restriction
desacyl-ghrelin
physical activity
restrictive anorexia nervosa
weight recovery
Résumé en anglais : [en]
Anorexia nervosa (AN) is a severe metabopsychiatric disorder characterised by caloric intake restriction and often excessive physical exercise. Our aim is to assess in female AN patients and in a rodent model, the co-evolution ...
Lire la suite >Anorexia nervosa (AN) is a severe metabopsychiatric disorder characterised by caloric intake restriction and often excessive physical exercise. Our aim is to assess in female AN patients and in a rodent model, the co-evolution of physical activity and potential dysregulation of acyl-(AG) and desacyl-(DAG) ghrelin plasma concentrations during denutrition and weight recovery. AN inpatients were evaluated at inclusion (T0, = 29), half-(T1) and total (T2) weight recovery, and one month after discharge (T3, = 13). C57/Bl6 mice with access to a running wheel, were fed ad libitum or submitted to short-(15 days) or long-(50 days) term quantitative food restriction, followed by refeeding (20 days). In AN patients, AG and DAG rapidly decreased during weight recovery (T0 to T2), AG increased significantly one-month post discharge (T3), but only DAG plasma concentrations at T3 correlated negatively with BMI and positively with physical activity. In mice, AG and DAG both increased during short- and long-term food restriction. After 20 days of ad libitum feeding, DAG was associated to persistence of exercise alteration. The positive association of DAG with physical activity during caloric restriction and after weight recovery questions its role in the adaptation mechanisms to energy deprivation that need to be considered in recovery process in AN.Lire moins >
Lire la suite >Anorexia nervosa (AN) is a severe metabopsychiatric disorder characterised by caloric intake restriction and often excessive physical exercise. Our aim is to assess in female AN patients and in a rodent model, the co-evolution of physical activity and potential dysregulation of acyl-(AG) and desacyl-(DAG) ghrelin plasma concentrations during denutrition and weight recovery. AN inpatients were evaluated at inclusion (T0, = 29), half-(T1) and total (T2) weight recovery, and one month after discharge (T3, = 13). C57/Bl6 mice with access to a running wheel, were fed ad libitum or submitted to short-(15 days) or long-(50 days) term quantitative food restriction, followed by refeeding (20 days). In AN patients, AG and DAG rapidly decreased during weight recovery (T0 to T2), AG increased significantly one-month post discharge (T3), but only DAG plasma concentrations at T3 correlated negatively with BMI and positively with physical activity. In mice, AG and DAG both increased during short- and long-term food restriction. After 20 days of ad libitum feeding, DAG was associated to persistence of exercise alteration. The positive association of DAG with physical activity during caloric restriction and after weight recovery questions its role in the adaptation mechanisms to energy deprivation that need to be considered in recovery process in AN.Lire moins >
Langue :
Anglais
Comité de lecture :
Oui
Audience :
Non spécifiée
Établissement(s) :
Université de Lille
CNRS
CHU Lille
CNRS
CHU Lille
Date de dépôt :
2022-05-04T12:33:04Z
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- Duriez et al. 2020 JCM.pdf
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