Metabolic and neuroendocrine adaptations ...
Type de document :
Article dans une revue scientifique: Article de synthèse/Review paper
DOI :
PMID :
URL permanente :
Titre :
Metabolic and neuroendocrine adaptations to undernutrition in anorexia nervosa: from a clinical to a basic research point of view.
Auteur(s) :
Viltart, Odile [Auteur]
Institut de psychiatrie et neurosciences de Paris [IPNP - U1266 Inserm - Paris Descartes]
Sciences Cognitives et Sciences Affectives (SCALab) - UMR 9193
Duriez, Philibert [Auteur]
Centre Hospitalier Sainte Anne [Paris]
Tolle, Virginie [Auteur]
Université Paris Descartes - Paris 5 [UPD5]
Institut de psychiatrie et neurosciences de Paris [IPNP - U1266 Inserm - Paris Descartes]
Sciences Cognitives et Sciences Affectives (SCALab) - UMR 9193
Duriez, Philibert [Auteur]
Centre Hospitalier Sainte Anne [Paris]
Tolle, Virginie [Auteur]
Université Paris Descartes - Paris 5 [UPD5]
Titre de la revue :
Hormone Molecular Biology and Clinical Investigation
Nom court de la revue :
Horm Mol Biol Clin Investig
Numéro :
36
Date de publication :
2018-03-28
ISSN :
1868-1891
Mot(s)-clé(s) en anglais :
Adaptation, Physiological
Animals
Anorexia Nervosa
Ghrelin
Glucocorticoids
Humans
Leptin
Malnutrition
anorexia nervosa
hormones
metabolic
neuroendocrine
psychiatric disorder
undernutrition
Animals
Anorexia Nervosa
Ghrelin
Glucocorticoids
Humans
Leptin
Malnutrition
anorexia nervosa
hormones
metabolic
neuroendocrine
psychiatric disorder
undernutrition
Discipline(s) HAL :
Sciences cognitives
Résumé en anglais : [en]
The exact mechanisms linking metabolic and neuroendocrine adaptations to undernutrition and the pathophysiology of anorexia nervosa (AN) are not fully understood. AN is a psychiatric disorder of complex etiology characterized ...
Lire la suite >The exact mechanisms linking metabolic and neuroendocrine adaptations to undernutrition and the pathophysiology of anorexia nervosa (AN) are not fully understood. AN is a psychiatric disorder of complex etiology characterized by extreme starvation while the disease is progressing into a chronic state. Metabolic and endocrine alterations associated to this disorder are part of a powerful response to maintain whole body energy homeostasis. But these modifications may also contribute to associated neuropsychiatric symptoms (reward abnormalities, anxiety, depression) and thus participate to sustain the disease. The current review presents data with both a clinical and basic research point of view on the role of nutritional and energy sensors with neuroendocrine actions in the pathophysiology of the disease, as they modulate metabolic responses, reproductive functions, stress responses as well as physical activity. While clinical data present a full description of changes occurring in AN, animal models that integrate either spontaneous genetic mutations or experimentally-induced food restriction with hyperactivity and/or social stress recapitulate the main metabolic and endocrine alterations of AN and provide mechanistic information between undernutrition state and symptoms of the disease. Further progress on the central and peripheral mechanism involved in the pathophysiology of eating disorders partly relies on the development and/or refinement of existing animal models to include recently identified genetic traits and better mimic the complex and multifactorial dimensions of the disease.Lire moins >
Lire la suite >The exact mechanisms linking metabolic and neuroendocrine adaptations to undernutrition and the pathophysiology of anorexia nervosa (AN) are not fully understood. AN is a psychiatric disorder of complex etiology characterized by extreme starvation while the disease is progressing into a chronic state. Metabolic and endocrine alterations associated to this disorder are part of a powerful response to maintain whole body energy homeostasis. But these modifications may also contribute to associated neuropsychiatric symptoms (reward abnormalities, anxiety, depression) and thus participate to sustain the disease. The current review presents data with both a clinical and basic research point of view on the role of nutritional and energy sensors with neuroendocrine actions in the pathophysiology of the disease, as they modulate metabolic responses, reproductive functions, stress responses as well as physical activity. While clinical data present a full description of changes occurring in AN, animal models that integrate either spontaneous genetic mutations or experimentally-induced food restriction with hyperactivity and/or social stress recapitulate the main metabolic and endocrine alterations of AN and provide mechanistic information between undernutrition state and symptoms of the disease. Further progress on the central and peripheral mechanism involved in the pathophysiology of eating disorders partly relies on the development and/or refinement of existing animal models to include recently identified genetic traits and better mimic the complex and multifactorial dimensions of the disease.Lire moins >
Langue :
Anglais
Comité de lecture :
Oui
Audience :
Internationale
Vulgarisation :
Non
Établissement(s) :
Université de Lille
CNRS
CHU Lille
CNRS
CHU Lille
Date de dépôt :
2022-05-04T12:42:01Z
2022-05-11T07:59:07Z
2022-05-11T07:59:07Z
Fichiers
- Viltart et al. 2018 HMBCI.pdf
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