Title :

The emerging landscape of single-molecule protein sequencing technologies

Author(s) :

Alfaro, Javier Antonio [Auteur]
Medical University of Gdańsk
Bohlander, Peggy [Auteur]
Delft University of Technology [TU Delft]
Dai, Mingjie [Auteur]
Harvard University [Cambridge]
Filius, Mike [Auteur]
Delft University of Technology [TU Delft]
Howard, Cecil J. [Auteur]
University of Texas at Austin [Austin]
Van Kooten, Xander F. [Auteur]
Ohayon, Shilo [Auteur]
Technion - Israel Institute of Technology [Haifa]
Pomorski, Adam [Auteur]
Delft University of Technology [TU Delft]
Schmid, Sonja [Auteur]
Wageningen University and Research [Wageningen] [WUR]
Aksimentiev, Aleksei [Auteur]
University of Illinois at Urbana-Champaign [Urbana]
Anslyn, Eric V. [Auteur]
University of Texas at Austin [Austin]
Bedran, Georges [Auteur]
Cao, Chan [Auteur]
Ecole Polytechnique Fédérale de Lausanne [EPFL]
Chinappi, Mauro [Auteur]
Coyaud, Etienne-Marie [Auteur]
Protéomique, Réponse Inflammatoire, Spectrométrie de Masse (PRISM) - U1192
Dekker, Cees [Auteur]
Delft University of Technology [TU Delft]
Dittmar, Gunnar [Auteur]
University of Luxembourg [Luxembourg]
Drachman, Nicholas [Auteur]
Brown University
Eelkema, Rienk [Auteur]
Delft University of Technology [TU Delft]
Goodlett, David R. [Auteur]
Hentz, Sebastien [Auteur]
Kalathiya, Umesh [Auteur]
Kelleher, Neil L. [Auteur]
Kelly, Ryan T. [Auteur]
Kelman, Zvi [Auteur]
Kim, Sung Hyun [Auteur]
Kuster, Bernhard [Auteur]
Rodriguez-Larrea, David [Auteur]
Lindsay, Stuart [Auteur]
Maglia, Giovanni [Auteur]
Marcotte, Edward M. [Auteur]
Marino, John P. [Auteur]
Masselon, Christophe [Auteur]
Mayer, Michael [Auteur]
Samaras, Patroklos [Auteur]
Sarthak, Kumar [Auteur]
Sepiashvili, Lusia [Auteur]
Stein, Derek [Auteur]
Wanunu, Meni [Auteur]
Northeastern University [Boston]
Wilhelm, Mathias [Auteur]
Technische Universität Munchen - Université Technique de Munich [Munich, Allemagne] [TUM]
Yin, Peng [Auteur]
Harvard University [Cambridge]
Meller, Amit [Auteur]
Technion - Israel Institute of Technology [Haifa]
Joo, Chirlmin [Auteur]
Delft University of Technology [TU Delft]

Journal title :

Nature Methods

Abbreviated title :

Nat. Methods

Volume number :

18

Pages :

604-617

Publication date :

2021-06-01

ISSN :

1548-7091

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Single-cell profiling methods have had a profound impact on the understanding of cellular heterogeneity. While genomes and transcriptomes can be explored at the single-cell level, single-cell profiling of proteomes is not ...
Show more >Single-cell profiling methods have had a profound impact on the understanding of cellular heterogeneity. While genomes and transcriptomes can be explored at the single-cell level, single-cell profiling of proteomes is not yet established. Here we describe new single-molecule protein sequencing and identification technologies alongside innovations in mass spectrometry that will eventually enable broad sequence coverage in single-cell profiling. These technologies will in turn facilitate biological discovery and open new avenues for ultrasensitive disease diagnostics.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

INSERM
Université de Lille

Collections :

• Protéomique, Réponse Inflammatoire, Spectrométrie de Masse (PRISM) - U1192

Submission date :

2022-06-15T13:58:17Z
2023-03-08T10:56:35Z