Robot-assisted spidermass for in vivo ...
Type de document :
Article dans une revue scientifique: Article original
PMID :
URL permanente :
Titre :
Robot-assisted spidermass for in vivo real-time topography mass spectrometry imaging
Auteur(s) :
Ogrinc, Nina [Auteur]
Protéomique, Réponse Inflammatoire, Spectrométrie de Masse (PRISM) - U1192
Kruszewski, Alexandre [Auteur]
Centre de Recherche en Informatique, Signal et Automatique de Lille (CRIStAL) - UMR 9189
Chaillou, Paul [Auteur]
Saudemont, Philippe [Auteur]
Protéomique, Réponse Inflammatoire, Spectrométrie de Masse (PRISM) - U1192
Lagadec, Chann [Auteur]
Cancer Heterogeneity, Plasticity and Resistance to Therapies (CANTHER) - UMR 9020 - UMR 1277
Salzet, Michel [Auteur]
Protéomique, Réponse Inflammatoire, Spectrométrie de Masse (PRISM) - U1192
Duriez, Christian [Auteur]
Centre de Recherche en Informatique, Signal et Automatique de Lille (CRIStAL) - UMR 9189
FOURNIER, Isabelle [Auteur]
Protéomique, Réponse Inflammatoire, Spectrométrie de Masse (PRISM) - U1192
Protéomique, Réponse Inflammatoire, Spectrométrie de Masse (PRISM) - U1192
Kruszewski, Alexandre [Auteur]
Centre de Recherche en Informatique, Signal et Automatique de Lille (CRIStAL) - UMR 9189
Chaillou, Paul [Auteur]
Saudemont, Philippe [Auteur]
Protéomique, Réponse Inflammatoire, Spectrométrie de Masse (PRISM) - U1192
Lagadec, Chann [Auteur]
Cancer Heterogeneity, Plasticity and Resistance to Therapies (CANTHER) - UMR 9020 - UMR 1277
Salzet, Michel [Auteur]
Protéomique, Réponse Inflammatoire, Spectrométrie de Masse (PRISM) - U1192
Duriez, Christian [Auteur]
Centre de Recherche en Informatique, Signal et Automatique de Lille (CRIStAL) - UMR 9189
FOURNIER, Isabelle [Auteur]
Protéomique, Réponse Inflammatoire, Spectrométrie de Masse (PRISM) - U1192
Titre de la revue :
Analytical Chemistry
Nom court de la revue :
Anal Chem
Date de publication :
2021-10-20
ISSN :
1520-6882
Discipline(s) HAL :
Sciences du Vivant [q-bio]
Résumé en anglais : [en]
Mass spectrometry imaging (MSI) has shown to bring invaluable information for biological and clinical applications. However, conventional MSI is generally performed ex vivo from tissue sections. Here, we developed a novel ...
Lire la suite >Mass spectrometry imaging (MSI) has shown to bring invaluable information for biological and clinical applications. However, conventional MSI is generally performed ex vivo from tissue sections. Here, we developed a novel MS-based method for in vivo mass spectrometry imaging. By coupling the SpiderMass technology, that provides in vivo minimally invasive analysis-to a robotic arm of high accuracy, we demonstrate that images can be acquired from any surface by moving the laser probe above the surface. By equipping the robotic arm with a sensor, we are also able to both get the topography image of the sample surface and the molecular distribution, and then and plot back the molecular data, directly to the 3D topographical image without the need for image fusion. This is shown for the first time with the 3D topographic MS-based whole-body imaging of a mouse. Enabling fast in vivo MSI bridged to topography paves the way for surgical applications to excision margins.Lire moins >
Lire la suite >Mass spectrometry imaging (MSI) has shown to bring invaluable information for biological and clinical applications. However, conventional MSI is generally performed ex vivo from tissue sections. Here, we developed a novel MS-based method for in vivo mass spectrometry imaging. By coupling the SpiderMass technology, that provides in vivo minimally invasive analysis-to a robotic arm of high accuracy, we demonstrate that images can be acquired from any surface by moving the laser probe above the surface. By equipping the robotic arm with a sensor, we are also able to both get the topography image of the sample surface and the molecular distribution, and then and plot back the molecular data, directly to the 3D topographical image without the need for image fusion. This is shown for the first time with the 3D topographic MS-based whole-body imaging of a mouse. Enabling fast in vivo MSI bridged to topography paves the way for surgical applications to excision margins.Lire moins >
Langue :
Anglais
Comité de lecture :
Oui
Audience :
Internationale
Vulgarisation :
Non
Établissement(s) :
CNRS
Centrale Lille
INSERM
Université de Lille
Centrale Lille
INSERM
Université de Lille
Collections :
Date de dépôt :
2022-06-15T13:58:21Z
2023-02-15T12:43:40Z
2023-02-15T12:43:40Z
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