Brain cortex microglia derived exosomes: novel nanoparticles for glioma therapy

Murgoci, Adriana-Natalia; Cizkova, Dasa; Majerova, Petra; Petrovova, Eva; Medvecky, Lubomir; FOURNIER, Isabelle; Salzet, Michel

Document type :

Article dans une revue scientifique: Article original

DOI :

10.1002/cphc.201701198

PMID :

29327816

Permalink :

http://hdl.handle.net/20.500.12210/75075

Title :

Brain cortex microglia derived exosomes: novel nanoparticles for glioma therapy

Author(s) :

Murgoci, Adriana-Natalia [Auteur]
Cizkova, Dasa [Auteur]
Majerova, Petra [Auteur]
Petrovova, Eva [Auteur]
Medvecky, Lubomir [Auteur]
FOURNIER, Isabelle [Auteur]

Protéomique, Réponse Inflammatoire, Spectrométrie de Masse (PRISM) - U1192
Salzet, Michel [Auteur]

Protéomique, Réponse Inflammatoire, Spectrométrie de Masse (PRISM) - U1192

Journal title :

Chemphyschem . a European journal of chemical physics and physical chemistry

Abbreviated title :

Chemphyschem

Publication date :

2018-01-12

ISSN :

1439-7641

Keyword(s) :

extracellular vesicles
nanoparticles
exosomes
central nervous system
microglia cells

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

The function and integrity of the nervous system require interactive exchanges among neurons and glial cells. Exosomes and other extracellular vesicles (EVs) are emerging as a key mediator of intercellular communication, ...
Show more >The function and integrity of the nervous system require interactive exchanges among neurons and glial cells. Exosomes and other extracellular vesicles (EVs) are emerging as a key mediator of intercellular communication, capable of transferring nucleic acids, proteins and lipids influencing numerous functional and pathological aspects of both donor and recipient cells. The immune response mediated by microglia-derived exosomes is most prominently involved in the spread of neuroinflammation, neurodegenerative disorders, and brain cancer. Therefore, in the present study we describe a reproducible and highly efficient method for yielding purified primary microglia cells, followed by exosome isolation and their characterization. An in vitro biological assay demonstrates that microglia-derived exosomes tested on a 3D spheroid glioma culture were able to inhibit tumor invasion in time course. These results evidence that brain microglia-derived exosomes could be used as nanotherapeutic agents against glioma cells.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

INSERM
Université de Lille

Collections :

Protéomique, Réponse Inflammatoire, Spectrométrie de Masse (PRISM) - U1192

Submission date :

2022-06-15T13:58:32Z

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