Title :

Two-dimensional mass spectrometry: new perspectives for tandem mass spectrometry

Author(s) :

van Agthoven, Maria [Auteur]
Lam, Yuko [Auteur]
O’connor, Peter [Auteur]
Rolando, Christian [Auteur]
Miniaturisation pour la Synthèse, l’Analyse et la Protéomique - UAR 3290 [MSAP]
Delsuc, Marc-André [Auteur]
Institut de Génétique et de Biologie Moléculaire et Cellulaire [IGBMC]
Centre de Biochimie Structurale [Montpellier] [CBS]

Journal title :

European Biophysics Journal

Pages :

213-229

Publisher :

Springer Verlag (Germany)

Publication date :

2019-04

ISSN :

0175-7571

English keyword(s) :

Mass spectrometry
Two dimensional
Fourier transform
Fourier transform ion cyclotron resonance mass spectrometry
Tandem mass spectrometry

HAL domain(s) :

Chimie/Chimie analytique

English abstract : [en]

Fourier transform ion cyclotron resonance mass analysers (FT-ICR MS) can offer the highest resolutions and mass accuracies in mass spectrometry. Mass spectra acquired in an FT-ICR MS can yield accurate elemental compositions ...
Show more >Fourier transform ion cyclotron resonance mass analysers (FT-ICR MS) can offer the highest resolutions and mass accuracies in mass spectrometry. Mass spectra acquired in an FT-ICR MS can yield accurate elemental compositions of all compounds in a complex sample. Fragmentation caused by ion-neutral, ion-electron, or ion-photon interactions leads to more detailed structural information on compounds. The most often used method to correlate compounds and their fragment ions is to isolate the precursor ions from the sample before fragmentation. Two-dimensional mass spectrometry (2D MS) offers a method to correlate precursor and fragment ions without requiring precursor isolation. 2D MS therefore enables easy access to the fragmentation patterns of all compounds from complex samples. In this article, the principles of FT-ICR MS are reviewed and the 2D MS experiment is explained. Data processing for 2D MS is detailed, and the interpretation of 2D mass spectra is described.Show less >

Language :

Anglais

Popular science :

Non

ANR Project :

Spectrométrie de Masse à Résonance Cyclotronique Ionique Bidimensionelle en un Seul Spectre

Collections :

• Miniaturisation pour la Synthèse, l'Analyse et la Protéomique (MSAP) - USR 3290

Source :

Harvested from HAL