Title :

Interaction between Bacteria and the Immune System for Cancer Immunotherapy: The α-GalCer Alliance

Author(s) :

Ustjanzew, Arsenij [Auteur]
University Medical Center of the Johannes Gutenberg-University Mainz
Sencio, Valentin [Auteur]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Trottein, Francois [Auteur]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Faber, Jörg [Auteur]
University Medical Center of the Johannes Gutenberg-University Mainz
Sandhoff, Roger [Auteur]
German Cancer Research Center - Deutsches Krebsforschungszentrum [Heidelberg] [DKFZ]
Paret, Claudia [Auteur]
University Medical Center of the Johannes Gutenberg-University Mainz

Journal title :

International Journal of Molecular Sciences

Pages :

5896

Publisher :

MDPI

Publication date :

2022-06-24

ISSN :

1661-6596

English keyword(s) :

microbiome
microbiota
alpha-galactosylceramide
biomarkers
colorectal cancer
iNKT
immunotherapy

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Non-conventional T cells, such as γδ T and invariant natural killer T (iNKT) cells, are emerging players in fighting cancer. Alpha-galactosylceramide (α-GalCer) is used as an exogenous ligand to activate iNKT cells. Human ...
Show more >Non-conventional T cells, such as γδ T and invariant natural killer T (iNKT) cells, are emerging players in fighting cancer. Alpha-galactosylceramide (α-GalCer) is used as an exogenous ligand to activate iNKT cells. Human cells don’t have a direct pathway producing α-GalCer, which, however, can be produced by bacteria. We searched the literature for bacteria strains that are able to produce α-GalCer and used available sequencing data to analyze their presence in human tumor tissues and their association with survival. The modulatory effect of antibiotics on the concentration of α-GalCer was analyzed in mice. The human gut bacteria Bacteroides fragilis, Bacteroides vulgatus, and Prevotella copri produce α-GalCer structures that are able to activate iNKT cells. In mice, α-GalCer was depleted upon treatment with vancomycin. The three species were detected in colon adenocarcinoma (COAD) and rectum adenocarcinoma tissues, and Prevotella copri was also detected in bone tumors and glioblastoma tissues. Bacteroides vulgatus in COAD tissues correlated with better survival. In conclusion, α-GalCer-producing bacteria are part of the human gut microbiome and can infiltrate tumor tissues. These results suggest a new mechanism of interaction between bacteria and immune cells: α-GalCer produced by bacteria may activate non-conventional T cells in tumor tissues, where they can exert a direct or indirect anti-tumor activity.Show less >

Language :

Anglais

Peer reviewed article :

Oui

Audience :

Internationale

Popular science :

Non

ANR Project :

Rôle de l'axe poumon/intestin/moelle osseuse et du microbiote au cours de la grippe

Collections :

• Centre d'Infection et d'Immunité de Lille (CIIL) - U1019 - UMR 9017

Source :

Harvested from HAL