A data compendium associating the genomes ...
Type de document :
Compte-rendu et recension critique d'ouvrage
Titre :
A data compendium associating the genomes of 12,289 Mycobacterium tuberculosis isolates with quantitative resistance phenotypes to 13 antibiotics
Auteur(s) :
Brankin, Alice [Auteur correspondant]
University of Oxford
Malone, Kerri [Auteur correspondant]
European Bioinformatics Institute [Hinxton] [EMBL-EBI]
Barilar, Ivan [Auteur]
Forschungszentrum Borstel - Research Center Borstel
Battaglia, Simone [Auteur]
IRCCS San Raffaele Scientific Institute [Milan, Italie]
Borroni, Emanuele [Auteur]
IRCCS San Raffaele Scientific Institute [Milan, Italie]
Pires Brandao, Angela [Auteur]
Casa de Oswaldo Cruz [Rio de Janeiro] [COC]
Instituto Adolfo Lutz [São Paulo, Brazil]
Cabibbe, Andrea Maurizio [Auteur]
IRCCS San Raffaele Scientific Institute [Milan, Italie]
Carter, Joshua [Auteur]
Stanford School of Medicine [Stanford]
Chetty, Darren [Auteur]
Africa Health Research Institute [Durban/Mtubatuba] [AHRI]
Cirillo, Daniela María [Auteur]
IRCCS San Raffaele Scientific Institute [Milan, Italie]
Claxton, Pauline [Auteur]
University of Edinburgh [Edin.]
Clifton, David [Auteur]
University of Oxford
Cohen, Ted [Auteur]
Yale School of Public Health [YSPH]
Coronel, Jorge [Auteur]
Universidad Peruana de Ciencias Aplicadas (Lima) [UPC]
Crook, Derrick [Auteur]
University of Oxford
Dreyer, Viola [Auteur]
Forschungszentrum Borstel - Research Center Borstel
Earle, Sarah [Auteur]
University of Oxford
Escuyer, Vincent [Auteur]
Wadsworth Center
Ferrazoli, Lucilaine [Auteur]
Instituto Adolfo Lutz [São Paulo, Brazil]
Gāo, George Fú [Auteur]
Chinese Center for Disease Control and Prevention
Gardy, Jennifer [Auteur]
Bill & Melinda Gates Foundation [Seattle]
Gharbia, Saheer [Auteur]
UK Health Security Agency [London] [UKHSA]
Teixeira Ghisi, Kelen [Auteur]
Instituto Adolfo Lutz [São Paulo, Brazil]
Ghodousi, Arash [Auteur]
Universita Vita Salute San Raffaele = Vita-Salute San Raffaele University [Milan, Italie] [UniSR]
IRCCS San Raffaele Scientific Institute [Milan, Italie]
Gibertoni Cruz, Ana Lúıza [Auteur]
University of Oxford
Grandjean, Louis [Auteur]
University College of London [London] [UCL]
Grazian, Clara [Auteur]
University of New South Wales [Sydney] [UNSW]
Groenheit, Ramona [Auteur]
Public Health Agency of Sweden
Guthrie, Jennifer [Auteur]
University of British Columbia [Vancouver]
Public Health Ontario - Santé publique Ontario
He, Wencong [Auteur]
Chinese Center for Disease Control and Prevention
Hoffmann, Harald [Auteur]
J., Sarah [Auteur]
University of Oxford
Hunt, Martin [Auteur]
European Bioinformatics Institute [Hinxton] [EMBL-EBI]
University of Oxford
Ismail, Nazir Ahmed [Auteur]
National Institute for Communicable Diseases [Johannesburg] [NICD]
Jarrett, Lisa [Auteur]
UK Health Security Agency [London] [UKHSA]
Joseph, Lavania [Auteur]
National Institute for Communicable Diseases [Johannesburg] [NICD]
Jou, Ruwen [Auteur]
Taipei Medical University
Kambli, Priti [Auteur]
Khot, Rukhsar [Auteur]
Knaggs, Jeff [Auteur]
European Bioinformatics Institute [Hinxton] [EMBL-EBI]
University of Oxford
Koch, Anastasia [Auteur]
University of Cape Town
Kohlerschmidt, Donna [Auteur]
Wadsworth Center
Kouchaki, Samaneh [Auteur]
University of Oxford
University of Surrey [UNIS]
Lachapelle, Alexander [Auteur]
University of Oxford
Lalvani, Ajit [Auteur]
Imperial College London
Grandjean Lapierre, Simon [Auteur]
Université de Montréal [UdeM]
Laurenson, Ian [Auteur]
University of Edinburgh [Edin.]
Letcher, Brice [Auteur]
European Bioinformatics Institute [Hinxton] [EMBL-EBI]
Lin, Wan-Hsuan [Auteur]
Taipei Medical University
Liu, Chunfa [Auteur]
Chinese Center for Disease Control and Prevention
Liu, Dongxin [Auteur]
Chinese Center for Disease Control and Prevention
Mandal, Ayan [Auteur]
PRA Health sciences [Mumbai]
Mansjö, Mikael [Auteur]
European Bioinformatics Institute [Hinxton] [EMBL-EBI]
Matias, Daniela [Auteur]
UK Health Security Agency [London] [UKHSA]
Meintjes, Graeme [Auteur]
University of Cape Town
de Freitas Mendes, Flávia [Auteur]
Instituto Adolfo Lutz [São Paulo, Brazil]
Merker, Matthias [Auteur]
Forschungszentrum Borstel - Research Center Borstel
Mihalic, Marina [Auteur]
Millard, James [Auteur]
Africa Health Research Institute [Durban/Mtubatuba] [AHRI]
Miotto, Paolo [Auteur]
IRCCS San Raffaele Scientific Institute [Milan, Italie]
Mistry, Nerges [Auteur]
PRA Health sciences [Mumbai]
Moore, David [Auteur]
London School of Hygiene and Tropical Medicine [LSHTM]
Universidad Peruana de Ciencias Aplicadas (Lima) [UPC]
Musser, Kimberlee A. [Auteur]
Wadsworth Center
Ngcamu, Dumisani [Auteur]
National Institute for Communicable Diseases [Johannesburg] [NICD]
Ngoc Nhung, Hoang [Auteur]
Oxford University Clinical Research Unit [Ho Chi Minh City] [OUCRU]
Niemann, Stefan [Auteur]
Forschungszentrum Borstel - Research Center Borstel
German Centre for Infection Research - partner site Hamburg-Lübeck-Borstel-Riems [DZIF]
Soli Nilgiriwala, Kayzad [Auteur]
PRA Health sciences [Mumbai]
Nimmo, Camus [Auteur]
University College of London [London] [UCL]
O'Donnell, Max [Auteur]
Columbia University Irving Medical Center [CUIMC]
Okozi, Nana [Auteur]
National Institute for Communicable Diseases [Johannesburg] [NICD]
Siqueira Oliveira, Rosangela [Auteur]
Instituto Adolfo Lutz [São Paulo, Brazil]
Omar, Shaheed Vally [Auteur]
National Institute for Communicable Diseases [Johannesburg] [NICD]
Paton, Nicholas [Auteur]
National University of Singapore [NUS]
Peto, Timothy Ea [Auteur]
University of Oxford
Watanabe Pinhata, Juliana Maira [Auteur]
Instituto Adolfo Lutz [São Paulo, Brazil]
Plesnik, Sara [Auteur]
Puyen, Zully [Auteur]
Socios En Salud [Lima, Peru]
Rabodoarivelo, Marie [Auteur]
Institut Pasteur de Madagascar
Rakotosamimanana, Niaina [Auteur]
Institut Pasteur de Madagascar
Rancoita, Paola [Auteur]
Universita Vita Salute San Raffaele = Vita-Salute San Raffaele University [Milan, Italie] [UniSR]
Rathod, Priti [Auteur]
UK Health Security Agency [London] [UKHSA]
Robinson, Esther [Auteur]
UK Health Security Agency [London] [UKHSA]
Rodger, Gillian [Auteur]
University of Oxford
Rodrigues, Camilla [Auteur]
Rodwell, Timothy [Auteur]
Foundation for Innovative New Diagnostics [FIND]
University of California [San Diego] [UC San Diego]
Roohi, Aysha [Auteur]
University of Oxford
Santos-Lazaro, David [Auteur]
Socios En Salud [Lima, Peru]
Shah, Sanchi [Auteur]
PRA Health sciences [Mumbai]
Kohl, Thomas Andreas [Auteur]
Forschungszentrum Borstel - Research Center Borstel
Smith, Grace [Auteur]
UK Health Security Agency [London] [UKHSA]
Solano, Walter [Auteur]
Universidad Peruana Cayetano Heredia [UPCH]
Spitaleri, Andrea [Auteur]
IRCCS San Raffaele Scientific Institute [Milan, Italie]
Universita Vita Salute San Raffaele = Vita-Salute San Raffaele University [Milan, Italie] [UniSR]
Supply, Philip [Auteur]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Steyn, Adrie [Auteur]
Africa Health Research Institute [Durban/Mtubatuba] [AHRI]
Surve, Utkarsha [Auteur]
Tahseen, Sabira [Auteur]
National TB control Program [Islamabad, Pakistan]
Thuong, Nguyen [Auteur]
Oxford University Clinical Research Unit [Ho Chi Minh City] [OUCRU]
Thwaites, Guy [Auteur]
Oxford University Clinical Research Unit [Ho Chi Minh City] [OUCRU]
University of Oxford
Todt, Katharina [Auteur]
Trovato, Alberto [Auteur]
IRCCS San Raffaele Scientific Institute [Milan, Italie]
Utpatel, Christian [Auteur]
Forschungszentrum Borstel - Research Center Borstel
van Rie, Annelies [Auteur]
University of Antwerp [UA]
Vijay, Srinivasan [Auteur]
University of Edinburgh [Edin.]
Walker, Timothy [Auteur]
University of Oxford
Oxford University Clinical Research Unit [Ho Chi Minh City] [OUCRU]
Walker, A. Sarah [Auteur]
University of Oxford
Warren, Robin M. [Auteur]
Stellenbosch University
Werngren, Jim [Auteur]
Public Health Agency of Sweden
Wijkander, Maria [Auteur]
Public Health Agency of Sweden
Wilkinson, Robert [Auteur]
The Francis Crick Institute [London]
Imperial College London
Wilson, Daniel [Auteur]
University of Oxford
Wintringer, Penelope [Auteur]
European Bioinformatics Institute [Hinxton] [EMBL-EBI]
Xiao, Yu-Xin [Auteur]
Taipei Medical University
Yang, Yang [Auteur]
University of Oxford
Shanghai Jiao Tong University School of Medicine
Zhao, Yanlin [Auteur]
Chinese Center for Disease Control and Prevention
Yao, Shen-Yuan [Auteur]
National Institute for Communicable Diseases [Johannesburg] [NICD]
Zhu, Baoli [Auteur]
Chinese Academy of Sciences [Beijing] [CAS]
Fowler, Philip [Auteur]
University of Oxford
Iqbal, Zamin [Auteur]
European Bioinformatics Institute [Hinxton] [EMBL-EBI]
University of Oxford
Malone, Kerri [Auteur correspondant]
European Bioinformatics Institute [Hinxton] [EMBL-EBI]
Barilar, Ivan [Auteur]
Forschungszentrum Borstel - Research Center Borstel
Battaglia, Simone [Auteur]
IRCCS San Raffaele Scientific Institute [Milan, Italie]
Borroni, Emanuele [Auteur]
IRCCS San Raffaele Scientific Institute [Milan, Italie]
Pires Brandao, Angela [Auteur]
Casa de Oswaldo Cruz [Rio de Janeiro] [COC]
Instituto Adolfo Lutz [São Paulo, Brazil]
Cabibbe, Andrea Maurizio [Auteur]
IRCCS San Raffaele Scientific Institute [Milan, Italie]
Carter, Joshua [Auteur]
Stanford School of Medicine [Stanford]
Chetty, Darren [Auteur]
Africa Health Research Institute [Durban/Mtubatuba] [AHRI]
Cirillo, Daniela María [Auteur]
IRCCS San Raffaele Scientific Institute [Milan, Italie]
Claxton, Pauline [Auteur]
University of Edinburgh [Edin.]
Clifton, David [Auteur]
University of Oxford
Cohen, Ted [Auteur]
Yale School of Public Health [YSPH]
Coronel, Jorge [Auteur]
Universidad Peruana de Ciencias Aplicadas (Lima) [UPC]
Crook, Derrick [Auteur]
University of Oxford
Dreyer, Viola [Auteur]
Forschungszentrum Borstel - Research Center Borstel
Earle, Sarah [Auteur]
University of Oxford
Escuyer, Vincent [Auteur]
Wadsworth Center
Ferrazoli, Lucilaine [Auteur]
Instituto Adolfo Lutz [São Paulo, Brazil]
Gāo, George Fú [Auteur]
Chinese Center for Disease Control and Prevention
Gardy, Jennifer [Auteur]
Bill & Melinda Gates Foundation [Seattle]
Gharbia, Saheer [Auteur]
UK Health Security Agency [London] [UKHSA]
Teixeira Ghisi, Kelen [Auteur]
Instituto Adolfo Lutz [São Paulo, Brazil]
Ghodousi, Arash [Auteur]
Universita Vita Salute San Raffaele = Vita-Salute San Raffaele University [Milan, Italie] [UniSR]
IRCCS San Raffaele Scientific Institute [Milan, Italie]
Gibertoni Cruz, Ana Lúıza [Auteur]
University of Oxford
Grandjean, Louis [Auteur]
University College of London [London] [UCL]
Grazian, Clara [Auteur]
University of New South Wales [Sydney] [UNSW]
Groenheit, Ramona [Auteur]
Public Health Agency of Sweden
Guthrie, Jennifer [Auteur]
University of British Columbia [Vancouver]
Public Health Ontario - Santé publique Ontario
He, Wencong [Auteur]
Chinese Center for Disease Control and Prevention
Hoffmann, Harald [Auteur]
J., Sarah [Auteur]
University of Oxford
Hunt, Martin [Auteur]
European Bioinformatics Institute [Hinxton] [EMBL-EBI]
University of Oxford
Ismail, Nazir Ahmed [Auteur]
National Institute for Communicable Diseases [Johannesburg] [NICD]
Jarrett, Lisa [Auteur]
UK Health Security Agency [London] [UKHSA]
Joseph, Lavania [Auteur]
National Institute for Communicable Diseases [Johannesburg] [NICD]
Jou, Ruwen [Auteur]
Taipei Medical University
Kambli, Priti [Auteur]
Khot, Rukhsar [Auteur]
Knaggs, Jeff [Auteur]
European Bioinformatics Institute [Hinxton] [EMBL-EBI]
University of Oxford
Koch, Anastasia [Auteur]
University of Cape Town
Kohlerschmidt, Donna [Auteur]
Wadsworth Center
Kouchaki, Samaneh [Auteur]
University of Oxford
University of Surrey [UNIS]
Lachapelle, Alexander [Auteur]
University of Oxford
Lalvani, Ajit [Auteur]
Imperial College London
Grandjean Lapierre, Simon [Auteur]
Université de Montréal [UdeM]
Laurenson, Ian [Auteur]
University of Edinburgh [Edin.]
Letcher, Brice [Auteur]
European Bioinformatics Institute [Hinxton] [EMBL-EBI]
Lin, Wan-Hsuan [Auteur]
Taipei Medical University
Liu, Chunfa [Auteur]
Chinese Center for Disease Control and Prevention
Liu, Dongxin [Auteur]
Chinese Center for Disease Control and Prevention
Mandal, Ayan [Auteur]
PRA Health sciences [Mumbai]
Mansjö, Mikael [Auteur]
European Bioinformatics Institute [Hinxton] [EMBL-EBI]
Matias, Daniela [Auteur]
UK Health Security Agency [London] [UKHSA]
Meintjes, Graeme [Auteur]
University of Cape Town
de Freitas Mendes, Flávia [Auteur]
Instituto Adolfo Lutz [São Paulo, Brazil]
Merker, Matthias [Auteur]
Forschungszentrum Borstel - Research Center Borstel
Mihalic, Marina [Auteur]
Millard, James [Auteur]
Africa Health Research Institute [Durban/Mtubatuba] [AHRI]
Miotto, Paolo [Auteur]
IRCCS San Raffaele Scientific Institute [Milan, Italie]
Mistry, Nerges [Auteur]
PRA Health sciences [Mumbai]
Moore, David [Auteur]
London School of Hygiene and Tropical Medicine [LSHTM]
Universidad Peruana de Ciencias Aplicadas (Lima) [UPC]
Musser, Kimberlee A. [Auteur]
Wadsworth Center
Ngcamu, Dumisani [Auteur]
National Institute for Communicable Diseases [Johannesburg] [NICD]
Ngoc Nhung, Hoang [Auteur]
Oxford University Clinical Research Unit [Ho Chi Minh City] [OUCRU]
Niemann, Stefan [Auteur]
Forschungszentrum Borstel - Research Center Borstel
German Centre for Infection Research - partner site Hamburg-Lübeck-Borstel-Riems [DZIF]
Soli Nilgiriwala, Kayzad [Auteur]
PRA Health sciences [Mumbai]
Nimmo, Camus [Auteur]
University College of London [London] [UCL]
O'Donnell, Max [Auteur]
Columbia University Irving Medical Center [CUIMC]
Okozi, Nana [Auteur]
National Institute for Communicable Diseases [Johannesburg] [NICD]
Siqueira Oliveira, Rosangela [Auteur]
Instituto Adolfo Lutz [São Paulo, Brazil]
Omar, Shaheed Vally [Auteur]
National Institute for Communicable Diseases [Johannesburg] [NICD]
Paton, Nicholas [Auteur]
National University of Singapore [NUS]
Peto, Timothy Ea [Auteur]
University of Oxford
Watanabe Pinhata, Juliana Maira [Auteur]
Instituto Adolfo Lutz [São Paulo, Brazil]
Plesnik, Sara [Auteur]
Puyen, Zully [Auteur]
Socios En Salud [Lima, Peru]
Rabodoarivelo, Marie [Auteur]
Institut Pasteur de Madagascar
Rakotosamimanana, Niaina [Auteur]
Institut Pasteur de Madagascar
Rancoita, Paola [Auteur]
Universita Vita Salute San Raffaele = Vita-Salute San Raffaele University [Milan, Italie] [UniSR]
Rathod, Priti [Auteur]
UK Health Security Agency [London] [UKHSA]
Robinson, Esther [Auteur]
UK Health Security Agency [London] [UKHSA]
Rodger, Gillian [Auteur]
University of Oxford
Rodrigues, Camilla [Auteur]
Rodwell, Timothy [Auteur]
Foundation for Innovative New Diagnostics [FIND]
University of California [San Diego] [UC San Diego]
Roohi, Aysha [Auteur]
University of Oxford
Santos-Lazaro, David [Auteur]
Socios En Salud [Lima, Peru]
Shah, Sanchi [Auteur]
PRA Health sciences [Mumbai]
Kohl, Thomas Andreas [Auteur]
Forschungszentrum Borstel - Research Center Borstel
Smith, Grace [Auteur]
UK Health Security Agency [London] [UKHSA]
Solano, Walter [Auteur]
Universidad Peruana Cayetano Heredia [UPCH]
Spitaleri, Andrea [Auteur]
IRCCS San Raffaele Scientific Institute [Milan, Italie]
Universita Vita Salute San Raffaele = Vita-Salute San Raffaele University [Milan, Italie] [UniSR]
Supply, Philip [Auteur]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Steyn, Adrie [Auteur]
Africa Health Research Institute [Durban/Mtubatuba] [AHRI]
Surve, Utkarsha [Auteur]
Tahseen, Sabira [Auteur]
National TB control Program [Islamabad, Pakistan]
Thuong, Nguyen [Auteur]
Oxford University Clinical Research Unit [Ho Chi Minh City] [OUCRU]
Thwaites, Guy [Auteur]
Oxford University Clinical Research Unit [Ho Chi Minh City] [OUCRU]
University of Oxford
Todt, Katharina [Auteur]
Trovato, Alberto [Auteur]
IRCCS San Raffaele Scientific Institute [Milan, Italie]
Utpatel, Christian [Auteur]
Forschungszentrum Borstel - Research Center Borstel
van Rie, Annelies [Auteur]
University of Antwerp [UA]
Vijay, Srinivasan [Auteur]
University of Edinburgh [Edin.]
Walker, Timothy [Auteur]
University of Oxford
Oxford University Clinical Research Unit [Ho Chi Minh City] [OUCRU]
Walker, A. Sarah [Auteur]
University of Oxford
Warren, Robin M. [Auteur]
Stellenbosch University
Werngren, Jim [Auteur]
Public Health Agency of Sweden
Wijkander, Maria [Auteur]
Public Health Agency of Sweden
Wilkinson, Robert [Auteur]
The Francis Crick Institute [London]
Imperial College London
Wilson, Daniel [Auteur]
University of Oxford
Wintringer, Penelope [Auteur]
European Bioinformatics Institute [Hinxton] [EMBL-EBI]
Xiao, Yu-Xin [Auteur]
Taipei Medical University
Yang, Yang [Auteur]
University of Oxford
Shanghai Jiao Tong University School of Medicine
Zhao, Yanlin [Auteur]
Chinese Center for Disease Control and Prevention
Yao, Shen-Yuan [Auteur]
National Institute for Communicable Diseases [Johannesburg] [NICD]
Zhu, Baoli [Auteur]
Chinese Academy of Sciences [Beijing] [CAS]
Fowler, Philip [Auteur]
University of Oxford
Iqbal, Zamin [Auteur]
European Bioinformatics Institute [Hinxton] [EMBL-EBI]
Titre de la revue :
PLoS Biology
Pagination :
e3001721
Éditeur :
Public Library of Science
Date de publication :
2022
ISSN :
1544-9173
Discipline(s) HAL :
Sciences du Vivant [q-bio]/Microbiologie et Parasitologie/Bactériologie
Sciences du Vivant [q-bio]/Biochimie, Biologie Moléculaire/Génomique, Transcriptomique et Protéomique [q-bio.GN]
Sciences du Vivant [q-bio]/Biochimie, Biologie Moléculaire/Génomique, Transcriptomique et Protéomique [q-bio.GN]
Résumé en anglais : [en]
The Comprehensive Resistance Prediction for Tuberculosis: an International Consortium (CRyPTIC) presents here a data compendium of 12,289 Mycobacterium tuberculosis global clinical isolates, all of which have undergone ...
Lire la suite >The Comprehensive Resistance Prediction for Tuberculosis: an International Consortium (CRyPTIC) presents here a data compendium of 12,289 Mycobacterium tuberculosis global clinical isolates, all of which have undergone whole-genome sequencing and have had their minimum inhibitory concentrations to 13 antitubercular drugs measured in a single assay. It is the largest matched phenotypic and genotypic dataset for M . tuberculosis to date. Here, we provide a summary detailing the breadth of data collected, along with a description of how the isolates were selected, collected, and uniformly processed in CRyPTIC partner laboratories across 23 countries. The compendium contains 6,814 isolates resistant to at least 1 drug, including 2,129 samples that fully satisfy the clinical definitions of rifampicin resistant (RR), multidrug resistant (MDR), pre-extensively drug resistant (pre-XDR), or extensively drug resistant (XDR). The data are enriched for rare resistance-associated variants, and the current limits of genotypic prediction of resistance status (sensitive/resistant) are presented by using a genetic mutation catalogue, along with the presence of suspected resistance-conferring mutations for isolates resistant to the newly introduced drugs bedaquiline, clofazimine, delamanid, and linezolid. Finally, a case study of rifampicin monoresistance demonstrates how this compendium could be used to advance our genetic understanding of rare resistance phenotypes. The data compendium is fully open source and it is hoped that it will facilitate and inspire future research for years to come.Lire moins >
Lire la suite >The Comprehensive Resistance Prediction for Tuberculosis: an International Consortium (CRyPTIC) presents here a data compendium of 12,289 Mycobacterium tuberculosis global clinical isolates, all of which have undergone whole-genome sequencing and have had their minimum inhibitory concentrations to 13 antitubercular drugs measured in a single assay. It is the largest matched phenotypic and genotypic dataset for M . tuberculosis to date. Here, we provide a summary detailing the breadth of data collected, along with a description of how the isolates were selected, collected, and uniformly processed in CRyPTIC partner laboratories across 23 countries. The compendium contains 6,814 isolates resistant to at least 1 drug, including 2,129 samples that fully satisfy the clinical definitions of rifampicin resistant (RR), multidrug resistant (MDR), pre-extensively drug resistant (pre-XDR), or extensively drug resistant (XDR). The data are enriched for rare resistance-associated variants, and the current limits of genotypic prediction of resistance status (sensitive/resistant) are presented by using a genetic mutation catalogue, along with the presence of suspected resistance-conferring mutations for isolates resistant to the newly introduced drugs bedaquiline, clofazimine, delamanid, and linezolid. Finally, a case study of rifampicin monoresistance demonstrates how this compendium could be used to advance our genetic understanding of rare resistance phenotypes. The data compendium is fully open source and it is hoped that it will facilitate and inspire future research for years to come.Lire moins >
Langue :
Anglais
Vulgarisation :
Non
Source :
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