Title :

Study protocol: MyoFit46-the cardiac sub-study of the MRC National Survey of Health and Development.

Author(s) :

Webber, M. [Auteur]
Falconer, D. [Auteur]
Alfarih, M. [Auteur]
Joy, G. [Auteur]
Chan, F. [Auteur]
Davie, C. [Auteur]
Hamill Howes, L. [Auteur]
Wong, A. [Auteur]
Rapala, A. [Auteur]
Bhuva, A. [Auteur]
Davies, R. H. [Auteur]
Morton, C. [Auteur]
Aguado-Sierra, J. [Auteur]
Vazquez, M. [Auteur]
Tao, Xuyuan [Auteur]
Génie des Matériaux Textiles - ULR 2461 [GEMTEX]
Krausz, G. [Auteur]
Tanackovic, S. [Auteur]
Guger, C. [Auteur]
Xue, H. [Auteur]
Kellman, P. [Auteur]
Pierce, I. [Auteur]
Schott, J. [Auteur]
Hardy, R. [Auteur]
Chaturvedi, N. [Auteur]
Rudy, Y. [Auteur]
Moon, J. C. [Auteur]
Lambiase, P. D. [Auteur]
Orini, M. [Auteur]
Hughes, A. D. [Auteur]
Captur, G. [Auteur]

Journal title :

BMC Cardiovascular Disorders

Abbreviated title :

BMC Cardiovasc Disord

Volume number :

22

Publication date :

2022-04-01

ISSN :

1471-2261

English keyword(s) :

Subclinical myocardial dysfunction
Cardiovascular health
Life course risk factors
Risk trajectories
Cardiovascular magnetic resonance
Electrocardiographic imaging
Myocardial tissue characterization
Perfusion
4-dimensional flow

HAL domain(s) :

Sciences de l'ingénieur [physics]

English abstract : [en]

Background The life course accumulation of overt and subclinical myocardial dysfunction contributes to older age mortality, frailty, disability and loss of independence. The Medical Research Council National Survey of ...
Show more >Background The life course accumulation of overt and subclinical myocardial dysfunction contributes to older age mortality, frailty, disability and loss of independence. The Medical Research Council National Survey of Health and Development (NSHD) is the world’s longest running continued surveillance birth cohort providing a unique opportunity to understand life course determinants of myocardial dysfunction as part of MyoFit46–the cardiac sub-study of the NSHD. Methods We aim to recruit 550 NSHD participants of approximately 75 years+ to undertake high-density surface electrocardiographic imaging (ECGI) and stress perfusion cardiovascular magnetic resonance (CMR). Through comprehensive myocardial tissue characterization and 4-dimensional flow we hope to better understand the burden of clinical and subclinical cardiovascular disease. Supercomputers will be used to combine the multi-scale ECGI and CMR datasets per participant. Rarely available, prospectively collected whole-of-life data on exposures, traditional risk factors and multimorbidity will be studied to identify risk trajectories, critical change periods, mediators and cumulative impacts on the myocardium. Discussion By combining well curated, prospectively acquired longitudinal data of the NSHD with novel CMR–ECGI data and sharing these results and associated pipelines with the CMR community, MyoFit46 seeks to transform our understanding of how early, mid and later-life risk factor trajectories interact to determine the state of cardiovascular health in older age.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
ENSAIT
Junia HEI

Collections :

• Génie des matériaux textiles (GEMTEX) - ULR 2641

Submission date :

2023-06-20T01:36:40Z
2024-02-21T11:29:55Z