The Gonadotropin-Releasing Hormone Associated ...
Document type :
Article dans une revue scientifique
DOI :
Permalink :
Title :
The Gonadotropin-Releasing Hormone Associated Peptide Reduces Calcium Entry in Prolactin-Secreting Cells*
Author(s) :
Vacher, P. [Auteur]
Seeburg, P.H. [Auteur]
Mariot, Pascal [Auteur]
Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 [IEMN]
Laboratoire de Physiologie Cellulaire - U 1003 [PHYCELL]
Dufy-Barbe, L. [Auteur]
Nikolics, K. [Auteur]
Kerdelhue, B. [Auteur]
Laboratoire de neurobiologie de la reproduction
Dufy, B. [Auteur]
Physiologie et physiopathologie de la signalisation cellulaire [PPSC]
Seeburg, P.H. [Auteur]
Mariot, Pascal [Auteur]

Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 [IEMN]
Laboratoire de Physiologie Cellulaire - U 1003 [PHYCELL]
Dufy-Barbe, L. [Auteur]
Nikolics, K. [Auteur]
Kerdelhue, B. [Auteur]
Laboratoire de neurobiologie de la reproduction
Dufy, B. [Auteur]
Physiologie et physiopathologie de la signalisation cellulaire [PPSC]
Journal title :
Endocrinology
Pages :
285-294
Publisher :
Endocrine Society
Publication date :
1991-01
ISSN :
0013-7227
HAL domain(s) :
Sciences du Vivant [q-bio]
English abstract : [en]
The precursor molecule to the GnRH contains a peptide named GnRH-associated peptide (GAP) with PRL-inhibiting properties. In this work, we have studied the electrophysiological properties and responses to GAP of three ...
Show more >The precursor molecule to the GnRH contains a peptide named GnRH-associated peptide (GAP) with PRL-inhibiting properties. In this work, we have studied the electrophysiological properties and responses to GAP of three different types of PRL-secreting cells: 1) the rat tumor cell line GH3, 2) normal rat pituitary cells in primary culture, and 3) human PRL-secreting adenoma cells. Using different but complementary techniques we show that GAP reduces intracellular Ca++ levels, [Ca++]i, and inhibits Ca++ transients in these cells. This reduction of [Ca++]i results from coordinate actions of GAP on K+ and Ca++ conductances and may explain the inhibitory effect of GAP on hormonal secretion by PRL-secreting cells.Show less >
Show more >The precursor molecule to the GnRH contains a peptide named GnRH-associated peptide (GAP) with PRL-inhibiting properties. In this work, we have studied the electrophysiological properties and responses to GAP of three different types of PRL-secreting cells: 1) the rat tumor cell line GH3, 2) normal rat pituitary cells in primary culture, and 3) human PRL-secreting adenoma cells. Using different but complementary techniques we show that GAP reduces intracellular Ca++ levels, [Ca++]i, and inhibits Ca++ transients in these cells. This reduction of [Ca++]i results from coordinate actions of GAP on K+ and Ca++ conductances and may explain the inhibitory effect of GAP on hormonal secretion by PRL-secreting cells.Show less >
Language :
Anglais
Source :
Submission date :
2023-09-21T09:28:33Z