Neuroimaging and biomarker evidence of ...
Document type :
Article dans une revue scientifique: Article original
PMID :
Permalink :
Title :
Neuroimaging and biomarker evidence of neurodegeneration in asthma.
Author(s) :
Rosenkranz, Melissa A [Auteur]
University of Wisconsin-Madison
Dean, Douglas C [Auteur]
University of Wisconsin-Madison
Bendlin, Barbara B [Auteur]
University of Wisconsin-Madison
Jarjour, Nizar N [Auteur]
University of Wisconsin-Madison
Esnault, Stephane [Auteur]
University of Wisconsin-Madison
Zetterberg, Henrik [Auteur]
Sahlgrenska University Hospital [Gothenburg]
Heslegrave, Amanda [Auteur]
University College of London [London] [UCL]
Evans, Michael D [Auteur]
Davidson, Richard J [Auteur]
University of Wisconsin-Madison
Busse, William W [Auteur]
University of Wisconsin-Madison
University of Wisconsin-Madison
Dean, Douglas C [Auteur]
University of Wisconsin-Madison
Bendlin, Barbara B [Auteur]
University of Wisconsin-Madison
Jarjour, Nizar N [Auteur]
University of Wisconsin-Madison
Esnault, Stephane [Auteur]
University of Wisconsin-Madison
Zetterberg, Henrik [Auteur]
Sahlgrenska University Hospital [Gothenburg]
Heslegrave, Amanda [Auteur]
University College of London [London] [UCL]
Evans, Michael D [Auteur]
Davidson, Richard J [Auteur]
University of Wisconsin-Madison
Busse, William W [Auteur]
University of Wisconsin-Madison
Journal title :
The journal of allergy and clinical immunology
Abbreviated title :
J Allergy Clin Immunol
Volume number :
149
Pages :
589-598.e6
Publisher :
Elsevier
Publication date :
2022-02-01
ISSN :
1097-6825
English keyword(s) :
Adolescent
Adult
Aged
Asthma
Biomarkers
Diffusion Magnetic Resonance Imaging
Female
Humans
Male
Middle Aged
Neurodegenerative Diseases
Neuroimaging
Severity of Illness Index
Young Adult
tau Proteins
Asthma
GFAP
NfL
dementia
diffusion-weighted imaging
inflammation
neurodegeneration
Adult
Aged
Asthma
Biomarkers
Diffusion Magnetic Resonance Imaging
Female
Humans
Male
Middle Aged
Neurodegenerative Diseases
Neuroimaging
Severity of Illness Index
Young Adult
tau Proteins
Asthma
GFAP
NfL
dementia
diffusion-weighted imaging
inflammation
neurodegeneration
HAL domain(s) :
Sciences du Vivant [q-bio]
English abstract : [en]
Epidemiologic studies have shown that Alzheimer's disease (AD) and related dementias (ADRD) are seen more frequently with asthma, especially with greater asthma severity or exacerbation frequency. To examine the changes ...
Show more >Epidemiologic studies have shown that Alzheimer's disease (AD) and related dementias (ADRD) are seen more frequently with asthma, especially with greater asthma severity or exacerbation frequency. To examine the changes in brain structure that may underlie this phenomenon, we examined diffusion-weighted magnetic resonance imaging (dMRI) and blood-based biomarkers of AD (phosphorylated tau 181, p-Tau181), neurodegeneration (neurofilament light chain, NfL), and glial activation (glial fibrillary acidic protein, GFAP). dMRI data were obtained in 111 individuals with asthma, ranging in disease severity from mild to severe, and 135 healthy controls. Regression analyses were used to test the relationships between asthma severity and neuroimaging measures, as well as AD pathology, neurodegeneration, and glial activation, indexed by plasma p-Tau181, NfL, and GFAP, respectively. Additional relationships were tested with cognitive function. Asthma participants had widespread and large-magnitude differences in several dMRI metrics, which were indicative of neuroinflammation and neurodegeneration, and which were robustly associated with GFAP and, to a lesser extent, NfL. The AD biomarker p-Tau181 was only minimally associated with neuroimaging outcomes. Further, asthma severity was associated with deleterious changes in neuroimaging outcomes, which in turn were associated with slower processing speed, a test of cognitive performance. Asthma, particularly when severe, is associated with characteristics of neuroinflammation and neurodegeneration, and may be a potential risk factor for neural injury and cognitive dysfunction. There is a need to determine how asthma may affect brain health and whether treatment directed toward characteristics of asthma associated with these risks can mitigate these effects.Show less >
Show more >Epidemiologic studies have shown that Alzheimer's disease (AD) and related dementias (ADRD) are seen more frequently with asthma, especially with greater asthma severity or exacerbation frequency. To examine the changes in brain structure that may underlie this phenomenon, we examined diffusion-weighted magnetic resonance imaging (dMRI) and blood-based biomarkers of AD (phosphorylated tau 181, p-Tau181), neurodegeneration (neurofilament light chain, NfL), and glial activation (glial fibrillary acidic protein, GFAP). dMRI data were obtained in 111 individuals with asthma, ranging in disease severity from mild to severe, and 135 healthy controls. Regression analyses were used to test the relationships between asthma severity and neuroimaging measures, as well as AD pathology, neurodegeneration, and glial activation, indexed by plasma p-Tau181, NfL, and GFAP, respectively. Additional relationships were tested with cognitive function. Asthma participants had widespread and large-magnitude differences in several dMRI metrics, which were indicative of neuroinflammation and neurodegeneration, and which were robustly associated with GFAP and, to a lesser extent, NfL. The AD biomarker p-Tau181 was only minimally associated with neuroimaging outcomes. Further, asthma severity was associated with deleterious changes in neuroimaging outcomes, which in turn were associated with slower processing speed, a test of cognitive performance. Asthma, particularly when severe, is associated with characteristics of neuroinflammation and neurodegeneration, and may be a potential risk factor for neural injury and cognitive dysfunction. There is a need to determine how asthma may affect brain health and whether treatment directed toward characteristics of asthma associated with these risks can mitigate these effects.Show less >
Language :
Anglais
Peer reviewed article :
Oui
Audience :
Internationale
Administrative institution(s) :
Université de Lille
Inserm
CHU Lille
Inserm
CHU Lille
Collections :
Submission date :
2023-10-18T12:01:06Z
2023-10-20T14:53:52Z
2023-11-08T10:43:06Z
2023-10-20T14:53:52Z
2023-11-08T10:43:06Z
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