CANTO-RT: One of the Largest Prospective ...
Document type :
Compte-rendu et recension critique d'ouvrage
DOI :
Title :
CANTO-RT: One of the Largest Prospective Multicenter Cohort of Early Breast Cancer Patients Treated with Radiotherapy including Full DICOM RT Data
Author(s) :
Sarrade, Thomas [Auteur]
Allodji, Rodrigue [Auteur]
Ghannam, Youssef [Auteur]
Auzac, Guillaume [Auteur]
Everhard, Sibille [Auteur]
Kirova, Youlia [Auteur]
Peignaux, Karine [Auteur]
Guilbert, Philippe [Auteur]
Pasquier, David [Auteur]
Université de Lille
Centre Régional de Lutte contre le Cancer Oscar Lambret [Lille] [UNICANCER/Lille]
Centre de Recherche en Informatique, Signal et Automatique de Lille - UMR 9189 [CRIStAL]
Racadot, Séverine [Auteur]
Bourgier, Céline [Auteur]
Ducornet, Sandrine [Auteur]
André, Fabrice [Auteur]
de Vathaire, Florent [Auteur]
Rivera, Sofia [Auteur]
Allodji, Rodrigue [Auteur]
Ghannam, Youssef [Auteur]
Auzac, Guillaume [Auteur]
Everhard, Sibille [Auteur]
Kirova, Youlia [Auteur]
Peignaux, Karine [Auteur]
Guilbert, Philippe [Auteur]
Pasquier, David [Auteur]

Université de Lille
Centre Régional de Lutte contre le Cancer Oscar Lambret [Lille] [UNICANCER/Lille]
Centre de Recherche en Informatique, Signal et Automatique de Lille - UMR 9189 [CRIStAL]
Racadot, Séverine [Auteur]
Bourgier, Céline [Auteur]
Ducornet, Sandrine [Auteur]
André, Fabrice [Auteur]
de Vathaire, Florent [Auteur]
Rivera, Sofia [Auteur]
Journal title :
Cancers
Pages :
751
Publisher :
MDPI
Publication date :
2023-02
ISSN :
2072-6694
HAL domain(s) :
Sciences du Vivant [q-bio]
English abstract : [en]
This article describes the methodology used and provides a characterization of the study population in CANTO-RT (CANcer TOxicities RadioTherapy). CANTO (NCT01993498) is a prospective clinical cohort study including patients ...
Show more >This article describes the methodology used and provides a characterization of the study population in CANTO-RT (CANcer TOxicities RadioTherapy). CANTO (NCT01993498) is a prospective clinical cohort study including patients with stage I-III BC from 26 French cancer centers. Patients matching all CANTO inclusion and exclusion criteria who received RT in one of the 10 top recruiting CANTO centers were selected. Individual full DICOM RT files were collected, pseudo-anonymized, structured and analyzed on the CANTO-RT/UNITRAD web platform. CANTO-RT included 3875 BC patients with a median follow-up of 64 months. Among the 3797 patients with unilateral RT, 3065 (80.4%) had breast-conserving surgery, and 2712 (71.5%) had sentinel node surgery. Tumor bed boost was delivered in 2658 patients (68.5%) and lymph node RT in 1356 patients (35%), including internal mammary chain in 844 patients (21.8%). Most patients (3691 (95.3%)) were treated with 3D conformal RT. Target volumes, organs at risk contours and dose/volume histograms were extracted after quality-control procedures. CANTO-RT is one of the largest early BC prospective cohorts with full individual clinical, biological, imaging and DICOM RT data available. It is a valuable resource for the identification and validation of clinical and dosimetric predictive factors of RT and multimodal treatment-related toxicities.Show less >
Show more >This article describes the methodology used and provides a characterization of the study population in CANTO-RT (CANcer TOxicities RadioTherapy). CANTO (NCT01993498) is a prospective clinical cohort study including patients with stage I-III BC from 26 French cancer centers. Patients matching all CANTO inclusion and exclusion criteria who received RT in one of the 10 top recruiting CANTO centers were selected. Individual full DICOM RT files were collected, pseudo-anonymized, structured and analyzed on the CANTO-RT/UNITRAD web platform. CANTO-RT included 3875 BC patients with a median follow-up of 64 months. Among the 3797 patients with unilateral RT, 3065 (80.4%) had breast-conserving surgery, and 2712 (71.5%) had sentinel node surgery. Tumor bed boost was delivered in 2658 patients (68.5%) and lymph node RT in 1356 patients (35%), including internal mammary chain in 844 patients (21.8%). Most patients (3691 (95.3%)) were treated with 3D conformal RT. Target volumes, organs at risk contours and dose/volume histograms were extracted after quality-control procedures. CANTO-RT is one of the largest early BC prospective cohorts with full individual clinical, biological, imaging and DICOM RT data available. It is a valuable resource for the identification and validation of clinical and dosimetric predictive factors of RT and multimodal treatment-related toxicities.Show less >
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Anglais
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Non
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