Title :

Impact of surgery and chemotherapy in ovarian sex cord-stromal tumors from the multicentric Salomé study including 469 patients. A TMRG and GINECO group study.

Author(s) :

Hanvic, B. [Auteur]
Lecuru, F. [Auteur]
Vanacker, H. [Auteur]
Pautier, P. [Auteur]
Narducci, Fabrice [Auteur]
Protéomique, Réponse Inflammatoire, Spectrométrie de Masse (PRISM) - U1192
Cherifi, F. [Auteur]
Floquet, A. [Auteur]
Angeles, M. A. [Auteur]
Berton, D. [Auteur]
Pomel, C. [Auteur]
Kalbacher, E. [Auteur]
Provansal, M. [Auteur]
Fernandez, Y. [Auteur]
Rouge, T. M. [Auteur]
Roméo, C. [Auteur]
Laas, E. [Auteur]
Morice, P. [Auteur]
Hudry, Delphine [Auteur]
Protéomique, Réponse Inflammatoire, Spectrométrie de Masse (PRISM) - U1192
Meriaux, E. [Auteur]
Guyon, F. [Auteur]
Illac-Vauquelin, C. [Auteur]
Selle, F. [Auteur]
Meeus, P. [Auteur]
Genestie, C. [Auteur]
Salleron, J. [Auteur]
Ray-Coquard, I. [Auteur]

Journal title :

Gynecologic Oncology

Abbreviated title :

Gynecol Oncol

Volume number :

174

Pages :

190-199

Publication date :

2023-05-22

ISSN :

1095-6859

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Objective Identifying prognostic factors and evaluating the impact of adjuvant chemotherapy in patients with sex cord stromal tumors (SCST) is crucial. In this study, we aimed to address these challenges. Methods We ...
Show more >Objective Identifying prognostic factors and evaluating the impact of adjuvant chemotherapy in patients with sex cord stromal tumors (SCST) is crucial. In this study, we aimed to address these challenges. Methods We conducted a retrospective analysis of data from 13 centers of the French Rare malignant gynecological tumors (TMRG) network. We enrolled 469 adult patients with malignant SCST who received upfront surgery since 2011 to July 2015. Results 75% were diagnosed with adult Granulosa cell tumors, and 23% had another subtype. With a median follow-up of 6.4 years, 154 patients (33%) developed a first recurrence, 82 (17%) two recurrences, and 49 (10%) three recurrences. Adjuvant chemotherapy was administered in 14.7% of patients at initial diagnosis. In relapse, perioperative chemotherapy was administered in 58.5%, 28.2%, and 23.8% of patients, respectively, in the first, second, and third relapse. In the first-line therapy, age under 70 years, FIGO stage, and complete surgery were associated with longer progression-free survival (PFS). Chemotherapy had no impact on PFS in early-stage disease (FIGO I-II). The PFS was similar using BEP or other chemotherapy regimens (HR 0.88 [0.43; 1.81]) in the first-line therapy. In case of recurrence, PFS was statistically prolonged by complete surgery, but perioperative chemotherapy use did not impact PFS. Conclusion Chemotherapy use did not impact survival in the first-line or relapse setting in SCST. Only surgery and its quality demonstrated benefit for PFS in ovarian SCST in any lines of treatment.Show less >

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
Inserm
CHU Lille

Collections :

• Protéomique, Réponse Inflammatoire, Spectrométrie de Masse (PRISM) - U1192

Submission date :

2023-12-13T03:44:18Z
2024-01-22T10:39:02Z