How pre-strain affects the chemo-torsional ...
Document type :
Article dans une revue scientifique: Article original
PMID :
Permalink :
Title :
How pre-strain affects the chemo-torsional response of the intervertebral disc.
Author(s) :
Derrouiche, A. [Auteur]
Laboratoire de Génie Civil et Géo-Environnement (LGCgE) - ULR 4515 [LGCgE]
Feki, F. [Auteur]
Zairi, Fahmi [Auteur]
Laboratoire Génie Civil et géo-Environnement (LGCgE) - ULR 4515
Taktak, R. [Auteur]
Moulart, M. [Auteur]
Qu, Z. [Auteur]
Laboratoire de Génie Civil et Géo-Environnement (LGCgE) - ULR 4515 [LGCgE]
Ismail, J. [Auteur]
Laboratoire de Génie Civil et Géo-Environnement (LGCgE) - ULR 4515 [LGCgE]
Charfi, S. [Auteur]
Haddar, N. [Auteur]
Zairi, Fahed [Auteur]
Hôpital Privé Le Bois Ramsay Santé [Lille]
Protéomique, Réponse Inflammatoire, Spectrométrie de Masse (PRISM) - U1192
Laboratoire de Génie Civil et Géo-Environnement (LGCgE) - ULR 4515 [LGCgE]
Feki, F. [Auteur]
Zairi, Fahmi [Auteur]

Laboratoire Génie Civil et géo-Environnement (LGCgE) - ULR 4515
Taktak, R. [Auteur]
Moulart, M. [Auteur]
Qu, Z. [Auteur]
Laboratoire de Génie Civil et Géo-Environnement (LGCgE) - ULR 4515 [LGCgE]
Ismail, J. [Auteur]
Laboratoire de Génie Civil et Géo-Environnement (LGCgE) - ULR 4515 [LGCgE]
Charfi, S. [Auteur]
Haddar, N. [Auteur]
Zairi, Fahed [Auteur]

Hôpital Privé Le Bois Ramsay Santé [Lille]
Protéomique, Réponse Inflammatoire, Spectrométrie de Masse (PRISM) - U1192
Journal title :
Clinical Biomechanics
Abbreviated title :
Clin Biomech (Bristol, Avon)
Volume number :
76
Pages :
105020
Publication date :
2020-05-24
ISSN :
1879-1271
English keyword(s) :
Intervertebral disc
Pre-strain
Torsion
Chemical sensitivity
Chemo-mechanical mechanisms
Pre-strain
Torsion
Chemical sensitivity
Chemo-mechanical mechanisms
HAL domain(s) :
Sciences du Vivant [q-bio]
English abstract : [en]
Background
The role of the axial pre-strain on the torsional response of the intervertebral disc remains largely undefined. Moreover, the chemo-mechanical interactions in disc tissues are still unclear and corresponding ...
Show more >Background The role of the axial pre-strain on the torsional response of the intervertebral disc remains largely undefined. Moreover, the chemo-mechanical interactions in disc tissues are still unclear and corresponding data are rare in the literature. The paper deals with an in-vitro study of the pre-strain effect on the chemical sensitivity of the disc torsional response. Methods Fifteen non-frozen ‘motion segments’ (two vertebrae and the intervening soft tissues) were extracted from the cervical spines of mature sheep. The motion segments were loaded in torsion at various saline concentrations and axial pre-strain levels in order to modulate the intradiscal pressure. After preconditioning with successive low-strain compressions at a magnitude of 0.1 mm (10 cycles at 0.05 mm/s), the motion segment was subjected to a cyclic torsion until a twisting level of 2 deg. at 0.05 deg./s while a constant axial pre-strain (in compression or in tension) is maintained, the saline concentration of the surrounding fluid bath being changed from hypo-osmotic condition to hyper-osmotic condition. Findings Analysis of variance shows that the saline concentration influences the torsional response only when the motion segments are pre-compressed (p < .001) with significant differences between hypo-osmotic condition and hyper-osmotic condition. Interpretation The combination of a compressive pre-strain with twisting amplifies the nucleus hydrostatic pressure on the annulus and the annulus collagen fibers tensions. The proteoglycans density increases with the compressive pre-strain and leads to higher chemical imbalances, which would explain the increase in chemical sensitivity of the disc torsional response.Show less >
Show more >Background The role of the axial pre-strain on the torsional response of the intervertebral disc remains largely undefined. Moreover, the chemo-mechanical interactions in disc tissues are still unclear and corresponding data are rare in the literature. The paper deals with an in-vitro study of the pre-strain effect on the chemical sensitivity of the disc torsional response. Methods Fifteen non-frozen ‘motion segments’ (two vertebrae and the intervening soft tissues) were extracted from the cervical spines of mature sheep. The motion segments were loaded in torsion at various saline concentrations and axial pre-strain levels in order to modulate the intradiscal pressure. After preconditioning with successive low-strain compressions at a magnitude of 0.1 mm (10 cycles at 0.05 mm/s), the motion segment was subjected to a cyclic torsion until a twisting level of 2 deg. at 0.05 deg./s while a constant axial pre-strain (in compression or in tension) is maintained, the saline concentration of the surrounding fluid bath being changed from hypo-osmotic condition to hyper-osmotic condition. Findings Analysis of variance shows that the saline concentration influences the torsional response only when the motion segments are pre-compressed (p < .001) with significant differences between hypo-osmotic condition and hyper-osmotic condition. Interpretation The combination of a compressive pre-strain with twisting amplifies the nucleus hydrostatic pressure on the annulus and the annulus collagen fibers tensions. The proteoglycans density increases with the compressive pre-strain and leads to higher chemical imbalances, which would explain the increase in chemical sensitivity of the disc torsional response.Show less >
Audience :
Internationale
Popular science :
Non
Administrative institution(s) :
Université de Lille
Inserm
CHU Lille
Inserm
CHU Lille
Collections :
Submission date :
2023-12-13T05:27:10Z
2024-01-23T16:18:27Z
2024-01-23T16:18:27Z