French Recommendations for Osteoporosis ...
Document type :
Article dans une revue scientifique: Article original
Title :
French Recommendations for Osteoporosis Prevention and Treatment in Patients with Prostate Cancer Treated by Androgen Deprivation
Author(s) :
Briot, Karine [Auteur]
Service de rhumatologie [CHU Cochin]
Paccou, Julien [Auteur]
Marrow Adiposity & Bone Lab - Adiposité Médullaire et Os - ULR 4490 [MABLab]
Beuzeboc, Philippe [Auteur]
Bonneterre, Jacques [Auteur]
Département de Sénologie
Bouvard, Béatrice [Auteur]
Groupe d'Études Remodelage Osseux et bioMatériaux [GEROM]
Confavreux, Cyrille [Auteur]
Physiopathologie, diagnostic et traitements des maladies osseuses / Pathophysiology, Diagnosis & Treatments of Bone Diseases [LYOS]
Cormier, Catherine [Auteur]
Service de rhumatologie [CHU Cochin]
Cortet, Bernard [Auteur]
Service de rhumatologie[Lille]
Hannoun-Lévi, Jean-Michel [Auteur]
Centre de Lutte contre le Cancer Antoine Lacassagne [Nice] [UNICANCER/CAL]
Hennequin, Christophe [Auteur]
Javier, Rose-Marie [Auteur]
Les Hôpitaux Universitaires de Strasbourg [HUS]
Lespessailles, Eric [Auteur]
Centre Hospitalier Régional d'Orléans [CHRO]
Mayeur, Didier [Auteur]
Institut mediterranéen des sciences de l'information et de la communication [IMSIC]
Mongiat Artus, Pierre [Auteur]
Vieillard, Marie-Hélène [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Debiais, Françoise [Auteur]
Centre hospitalier universitaire de Poitiers = Poitiers University Hospital [CHU de Poitiers [La Milétrie]]
Service de rhumatologie [CHU Cochin]
Paccou, Julien [Auteur]

Marrow Adiposity & Bone Lab - Adiposité Médullaire et Os - ULR 4490 [MABLab]
Beuzeboc, Philippe [Auteur]
Bonneterre, Jacques [Auteur]
Département de Sénologie
Bouvard, Béatrice [Auteur]
Groupe d'Études Remodelage Osseux et bioMatériaux [GEROM]
Confavreux, Cyrille [Auteur]
Physiopathologie, diagnostic et traitements des maladies osseuses / Pathophysiology, Diagnosis & Treatments of Bone Diseases [LYOS]
Cormier, Catherine [Auteur]
Service de rhumatologie [CHU Cochin]
Cortet, Bernard [Auteur]

Service de rhumatologie[Lille]
Hannoun-Lévi, Jean-Michel [Auteur]
Centre de Lutte contre le Cancer Antoine Lacassagne [Nice] [UNICANCER/CAL]
Hennequin, Christophe [Auteur]
Javier, Rose-Marie [Auteur]
Les Hôpitaux Universitaires de Strasbourg [HUS]
Lespessailles, Eric [Auteur]
Centre Hospitalier Régional d'Orléans [CHRO]
Mayeur, Didier [Auteur]
Institut mediterranéen des sciences de l'information et de la communication [IMSIC]
Mongiat Artus, Pierre [Auteur]
Vieillard, Marie-Hélène [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Debiais, Françoise [Auteur]
Centre hospitalier universitaire de Poitiers = Poitiers University Hospital [CHU de Poitiers [La Milétrie]]
Journal title :
Joint Bone Spine
Pages :
21-28
Publisher :
Elsevier Masson
Publication date :
2019
ISSN :
1297-319X
English keyword(s) :
Androgen deprivation therapy
bisphosphonates
Bone loss Fracture
Denosumab
LHRH agonists
osteoporosis
Prévention
Prostate cancer
recommendations
Surgical orchiectomy
bisphosphonates
Bone loss Fracture
Denosumab
LHRH agonists
osteoporosis
Prévention
Prostate cancer
recommendations
Surgical orchiectomy
HAL domain(s) :
Sciences du Vivant [q-bio]
English abstract : [en]
<p>Androgen-deprivation therapy (ADT) in patients with prostate cancer can be achieved surgically or chemically, notably by prescribing LHRH analogs. Major bone loss occurs rapidly in both cases, due to the decrease in ...
Show more ><p>Androgen-deprivation therapy (ADT) in patients with prostate cancer can be achieved surgically or chemically, notably by prescribing LHRH analogs. Major bone loss occurs rapidly in both cases, due to the decrease in testosterone levels, and can increase the fracture risk. The objective of developing these recommendations was to achieve a practical consensus among various scientific societies, based on a literature review, about osteoporosis prevention and treatment in patients on ADT. The following scientific societies contributed to the work: Société Française de Rhumatologie (SFR), Groupe de Recherche et d’Information sur les Ostéoporoses (GRIO), Groupe Européen d’Etudes des Métastases Osseuses (GEMO), Association Francophone pour les SOins de Support (AFSOS), Association Française d’Urologie (AFU), Société Française de Radiothérapie Oncologique (SFRO). Medication prescription and reimbursement modalities in France were taken into account. The recommendations state that a fracture-risk evaluation and interventions targeting risk factors for fractures should be provided to all patients on ADT. Those patients with a history of severe osteoporotic fracture and/or a T-score <-2.5 should receive osteoporosis therapy. Patients whose T-score is between -1.5 and -2.5 should be treated if they exhibit at least two other risk factors among the following: age ≥75 years, history of nonsevere fracture after 50 years of age, body mass index <19 kg/m², at least three comorbidities (e.g., cardiovascular disease, depression, Parkinson’s disease, and dementia), current glucocorticoid therapy, and repeated falls. When the decision is difficult, FRAX® score determination and an assessment by a bone disease specialist may be helpful. When osteoporosis therapy is not indicated, general measures should be applied, and bone mineral density measured again after 12-24 months. The anti-tumor effects of bisphosphonates and denosumab fall outside the scope of these recommendations.</p>Show less >
Show more ><p>Androgen-deprivation therapy (ADT) in patients with prostate cancer can be achieved surgically or chemically, notably by prescribing LHRH analogs. Major bone loss occurs rapidly in both cases, due to the decrease in testosterone levels, and can increase the fracture risk. The objective of developing these recommendations was to achieve a practical consensus among various scientific societies, based on a literature review, about osteoporosis prevention and treatment in patients on ADT. The following scientific societies contributed to the work: Société Française de Rhumatologie (SFR), Groupe de Recherche et d’Information sur les Ostéoporoses (GRIO), Groupe Européen d’Etudes des Métastases Osseuses (GEMO), Association Francophone pour les SOins de Support (AFSOS), Association Française d’Urologie (AFU), Société Française de Radiothérapie Oncologique (SFRO). Medication prescription and reimbursement modalities in France were taken into account. The recommendations state that a fracture-risk evaluation and interventions targeting risk factors for fractures should be provided to all patients on ADT. Those patients with a history of severe osteoporotic fracture and/or a T-score <-2.5 should receive osteoporosis therapy. Patients whose T-score is between -1.5 and -2.5 should be treated if they exhibit at least two other risk factors among the following: age ≥75 years, history of nonsevere fracture after 50 years of age, body mass index <19 kg/m², at least three comorbidities (e.g., cardiovascular disease, depression, Parkinson’s disease, and dementia), current glucocorticoid therapy, and repeated falls. When the decision is difficult, FRAX® score determination and an assessment by a bone disease specialist may be helpful. When osteoporosis therapy is not indicated, general measures should be applied, and bone mineral density measured again after 12-24 months. The anti-tumor effects of bisphosphonates and denosumab fall outside the scope of these recommendations.</p>Show less >
Language :
Anglais
Peer reviewed article :
Oui
Audience :
Internationale
Popular science :
Non
Collections :
Source :
Files
- S1297319X18303476.pdf
- Open access
- Access the document