Mild pulmonary hemodynamic alterations in ...
Document type :
Compte-rendu et recension critique d'ouvrage
Title :
Mild pulmonary hemodynamic alterations in patients with systemic sclerosis: relevance of the new 2022 ESC/ERS definition of pulmonary hypertension and impact on mortality
Author(s) :
Puigrenier, Sébastien [Auteur]
Giovannelli, Jonathan [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Lamblin, Nicolas [Auteur]
Facteurs de Risque et Déterminants Moléculaires des Maladies liées au Vieillissement - U 1167 [RID-AGE]
Institut Pasteur de Lille
Université de Lille
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
De Groote, Pascal [Auteur]
Facteurs de Risque et Déterminants Moléculaires des Maladies liées au Vieillissement - U 1167 [RID-AGE]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Fertin, Marie [Auteur]
Facteurs de Risque et Déterminants Moléculaires des Maladies liées au Vieillissement - U 1167 [RID-AGE]
Bervar, Jean-François [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Lamer, Antoine [Auteur]
Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS]
Pole Cardio-vasculaire et pulmonaire [CHU Lille]
Edmé, Jean-Louis [Auteur]
Impact de l'environnement chimique sur la santé humaine - ULR 4483 [IMPECS]
Balquet, Marie-Hélène [Auteur]
Centre Hospitalier de Lens
Sobanski, Vincent [Auteur]
Centre National de Référence des Maladies Auto-Immunes Systémiques Rares du Nord et Nord-Ouest de France [CeRAINO]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Institut universitaire de France [IUF]
Institute for Translational Research in Inflammation - U 1286 [INFINITE]
Launay, David [Auteur]
Institute for Translational Research in Inflammation - U 1286 [INFINITE]
Hachulla, Éric [Auteur]
Institute for Translational Research in Inflammation - U 1286 [INFINITE]
Sanges, Sébastien [Auteur]
Institute for Translational Research in Inflammation - U 1286 [INFINITE]
Giovannelli, Jonathan [Auteur]

Lille Inflammation Research International Center - U 995 [LIRIC]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Lamblin, Nicolas [Auteur]

Facteurs de Risque et Déterminants Moléculaires des Maladies liées au Vieillissement - U 1167 [RID-AGE]
Institut Pasteur de Lille
Université de Lille
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
De Groote, Pascal [Auteur]

Facteurs de Risque et Déterminants Moléculaires des Maladies liées au Vieillissement - U 1167 [RID-AGE]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Fertin, Marie [Auteur]
Facteurs de Risque et Déterminants Moléculaires des Maladies liées au Vieillissement - U 1167 [RID-AGE]
Bervar, Jean-François [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Lamer, Antoine [Auteur]

Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS]
Pole Cardio-vasculaire et pulmonaire [CHU Lille]
Edmé, Jean-Louis [Auteur]
Impact de l'environnement chimique sur la santé humaine - ULR 4483 [IMPECS]
Balquet, Marie-Hélène [Auteur]
Centre Hospitalier de Lens
Sobanski, Vincent [Auteur]

Centre National de Référence des Maladies Auto-Immunes Systémiques Rares du Nord et Nord-Ouest de France [CeRAINO]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Institut universitaire de France [IUF]
Institute for Translational Research in Inflammation - U 1286 [INFINITE]
Launay, David [Auteur]

Institute for Translational Research in Inflammation - U 1286 [INFINITE]
Hachulla, Éric [Auteur]
Institute for Translational Research in Inflammation - U 1286 [INFINITE]
Sanges, Sébastien [Auteur]
Institute for Translational Research in Inflammation - U 1286 [INFINITE]
Journal title :
Respiratory research
Pages :
284
Publisher :
BioMed Central
Publication date :
2022-12
ISSN :
1465-9921
HAL domain(s) :
Sciences du Vivant [q-bio]
English abstract : [en]
Abstract Background and objective The definition of pre-capillary pulmonary hypertension (PH) has been modified, with lowering of the mean pulmonary arterial pressure (mPAP) threshold from 25 to 20 mmHg and addition of a ...
Show more >Abstract Background and objective The definition of pre-capillary pulmonary hypertension (PH) has been modified, with lowering of the mean pulmonary arterial pressure (mPAP) threshold from 25 to 20 mmHg and addition of a mandatory criterion of pulmonary vascular resistance (PVR) ≥ 2 Wood units (WU). Our objectives were: 1/ to estimate the proportion of patients reclassified as having pre-capillary PH when using the new 2022 ESC/ERS hemodynamic criteria (i.e. mPAP 21-24 mmHg and PVR ≥ 2 WU), and to describe their clinical characteristics and outcome; and 2/ to study the relationship between PVR and survival in patients with mPAP > 20 mmHg. Methods We retrospectively analyzed consecutive SSc patients included in our National Reference Center for a first right-heart catheterization between 2003 and 2018. The association between survival and PVR was studied using smoothing splines. Results We included 126 SSc patients with mPAP > 20 mmHg. Among them, 16 (13%) had a baseline mPAP value between 21 and 24 mmHg and PVR ≥ 2 mmHg and were reclassified as pre-capillary PH; 10 of which (62%) raised their mPAP ≥ 25 mmHg during follow-up. In patients with mPAP > 20 mmHg, we observed a linear relation between PVR and mortality for values < 6 WU. Conclusion A significant proportion of SSc patients is reclassified as having pre-capillary PH with the new 2022 ESC/ERS hemodynamic definition. Lowering the PVR threshold from 3 to 2 WU captures patients at risk of raising their mPAP > 25 mmHg, with a possibly less severe disease.Show less >
Show more >Abstract Background and objective The definition of pre-capillary pulmonary hypertension (PH) has been modified, with lowering of the mean pulmonary arterial pressure (mPAP) threshold from 25 to 20 mmHg and addition of a mandatory criterion of pulmonary vascular resistance (PVR) ≥ 2 Wood units (WU). Our objectives were: 1/ to estimate the proportion of patients reclassified as having pre-capillary PH when using the new 2022 ESC/ERS hemodynamic criteria (i.e. mPAP 21-24 mmHg and PVR ≥ 2 WU), and to describe their clinical characteristics and outcome; and 2/ to study the relationship between PVR and survival in patients with mPAP > 20 mmHg. Methods We retrospectively analyzed consecutive SSc patients included in our National Reference Center for a first right-heart catheterization between 2003 and 2018. The association between survival and PVR was studied using smoothing splines. Results We included 126 SSc patients with mPAP > 20 mmHg. Among them, 16 (13%) had a baseline mPAP value between 21 and 24 mmHg and PVR ≥ 2 mmHg and were reclassified as pre-capillary PH; 10 of which (62%) raised their mPAP ≥ 25 mmHg during follow-up. In patients with mPAP > 20 mmHg, we observed a linear relation between PVR and mortality for values < 6 WU. Conclusion A significant proportion of SSc patients is reclassified as having pre-capillary PH with the new 2022 ESC/ERS hemodynamic definition. Lowering the PVR threshold from 3 to 2 WU captures patients at risk of raising their mPAP > 25 mmHg, with a possibly less severe disease.Show less >
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Anglais
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