Title :

Cell senescence: basic mechanisms and the need for computational networks in vascular ageing

Author(s) :

Regnault, Véronique [Auteur]
Défaillance Cardiovasculaire Aiguë et Chronique [DCAC]
Challande, Pascal [Auteur]
Institut Jean Le Rond d'Alembert [DALEMBERT]
PINET, FLORENCE [Auteur]
Facteurs de Risque et Déterminants Moléculaires des Maladies liées au Vieillissement - U 1167 [RID-AGE]
Li, Zhenlin [Auteur]
Adaptation Biologique et Vieillissement = Biological Adaptation and Ageing [B2A-IBPS]
Lacolley, Patrick [Auteur]
Défaillance Cardiovasculaire Aiguë et Chronique [DCAC]

Journal title :

Cardiovascular Research

Pages :

1841-1858

Publisher :

Oxford University Press (OUP)

Publication date :

2021-07-01

ISSN :

0008-6363

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Abstract This review seeks to provide an update of the mechanisms of vascular cell senescence, from newly identified molecules to arterial ageing phenotypes, and finally to present a computational approach to connect these ...
Show more >Abstract This review seeks to provide an update of the mechanisms of vascular cell senescence, from newly identified molecules to arterial ageing phenotypes, and finally to present a computational approach to connect these selected proteins in biological networks. We will discuss current key signalling and gene expression pathways by which these focus proteins and networks drive normal and accelerated vascular ageing. We also review the possibility that senolytic drugs, designed to restore normal cell differentiation and function, could effectively treat multiple age-related vascular diseases. Finally, we discuss how cell senescence is both a cause and a consequence of vascular ageing because of the possible feedback controls between identified networks.Show less >

Language :

Anglais

Peer reviewed article :

Oui

Audience :

Internationale

Popular science :

Non

Collections :

• Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement (RID-AGE) - U1167

Source :

Harvested from HAL