Title :

Incidence of indeterminate colitis in the EPIMAD registry decreases over the period 1988-2014

Author(s) :

Mayer, P. [Auteur]
Hôpital Claude Huriez [Lille]
Sarter, H. [Auteur]
Maison Régionale de la Recherche Clinique [Lille] [MRRC]
Service d'Epidémiologie et de Santé Publique [Lille]
Lille Inflammation Research International Center - U 995 [LIRIC]
Registre EPIMAD
Fumery, Mathurin [Auteur]
Périnatalité et Risques Toxiques - UMR INERIS_I 1 UPJV [PERITOX]
CHU Amiens-Picardie
Savoye, G. [Auteur]
Registre EPIMAD
Service d'Hépato-Gastroentérologie [CHU Rouen]
Leroyer, A. [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Institute for Translational Research in Inflammation - U 1286 [INFINITE]
Dauchet, L. [Auteur]
Facteurs de Risque et Déterminants Moléculaires des Maladies liées au Vieillissement - U 1167 [RID-AGE]
Gower-Rousseau, C. [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Registre EPIMAD
Lille Inflammation Research International Center - U 995 [LIRIC]
Pariente, B. [Auteur]
Hôpital Claude Huriez [Lille]

Journal title :

Journal of Crohn's and Colitis

Pages :

S494-S495

Publisher :

Elsevier - Oxford University Press

Publication date :

2019

ISSN :

1873-9946

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

BackgroundInflammatory bowel disease unclassified (IBDU) represents 5–15% of new diagnosis of inflammatory bowel disease. However, IBDU is not well defined and high rate of reclassification in Crohn’s disease (CD) or ...
Show more >BackgroundInflammatory bowel disease unclassified (IBDU) represents 5–15% of new diagnosis of inflammatory bowel disease. However, IBDU is not well defined and high rate of reclassification in Crohn’s disease (CD) or Ulcerative colitis (UC) is observed during follow-up. The objective of the present study was to evaluate the evolution of the incidence of IBDU over the period 1988–2014 in a population-based study and its reclassification rate during the follow-up.MethodsAll adults (> 17 years old) patients diagnosed with IBDU according to a validated and published algorithm1 in the French population-based registry EPIMAD from 1988 to 2014, were identified. Follow-up was divided in 3 periods of 9 years (1988–1996, 1997–2005, and 2006–2014). Reclassification was defined as a modification of diagnosis during the follow-up.Results24 304 IBD cases (> 17 years) were diagnosed, including 8449 (66.2%) CD, 3839 (30.1%) UC and 476 (3.7%) IBDU. IBDU concerned predominantly males compared with CD and UC population [(51.7% in IBDU population (n = 246) vs. 45.6% in CD plus UC population (n = 5602) (p = 0.009)], with an older age at diagnosis [(36 [26–51] in IBDU population vs. 30 [28–42] in CD plus UC population (p < 0.001)]. IBDU rate among IBD diagnosis decreased significantly during the study period, from 6% (1988–1996) to 2% (2006–2014) (p < 0.0001). In the IBDU cohort, 334 (70.2%) only had one diagnosis; 132 (27.7%) had two and 10 (2.1%) had three during follow-up. IBDU reclassification occurred in 108 patients (22.7%). The median time for reclassification was 1 year (IQR [1 −2]) after the diagnosis. Eighty-nine patients (18.7%) were reclassified to CD or UC after a new flare. There was no significant modification of IBDU reclassification rate in CD or UC during the study period 17% (1988–1996) to 21% (2005–2014) (p = 0.56).ConclusionsIn this population-based study, IBDU incidence decreased significantly between 1988 and 2014, probably because of better diagnosis performances allowing CD and UC identification. These results suggest that IBDU may not be a real and significant clinical entity but a misclassification of colonic inflammatory bowel disease.Show less >

Language :

Anglais

Peer reviewed article :

Oui

Audience :

Internationale

Popular science :

Non

Collections :

• Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement (RID-AGE) - U1167

Source :

Harvested from HAL