Title :

Evidence of IL-17, IP-10, and IL-10 involvement in multiple-organ dysfunction and IL-17 pathway in acute renal failure associated to Plasmodium falciparum malaria.

Author(s) :

Herbert, Fabien [Auteur]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Tchitchek, Nicolas [Auteur]
Immunologie des Maladies Virales et Autoimmunes [IMVA - U1184]
Bansal, Devendra [Auteur]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Jacques, Julien [Auteur]
Laboratoire Paul Painlevé - UMR 8524 [LPP]
Pathak, Sulabha [Auteur]
Tata Institute for Fundamental Research [TIFR]
Becavin, Christophe [Auteur]
Interactions Bactéries-Cellules [UIBC]
Fesel, Constantin [Auteur]
Instituto Gulbenkian de Ciência [Oeiras] [IGC]
Dalko, Esther [Auteur]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Cazenave, Pierre-André [Auteur]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Immunologie - Immunopathologie - Immunothérapie [CHU Pitié Salpêtrière] [I3]
Preda, Cristian [Auteur]
Laboratoire Paul Painlevé - UMR 8524 [LPP]
Ravindran, Balachandran [Auteur]
Indian Institute of technology Bhubaneswar
Sharma, Shobhona [Auteur]
Instituto Gulbenkian de Ciência [Oeiras] [IGC]
Das, Bidyut [Auteur]
Sriram Chandra Bhanj Medical College [Cuttack] [SCB Medical College]
Pied, Sylviane [Auteur]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]

Journal title :

Journal of Translational Medicine

Pages :

369

Publisher :

BioMed Central

Publication date :

2015

English keyword(s) :

Severe malaria
Cerebral malaria
Acute-renal failure
Malaria associated organ failure
IL-17
Cytokines
Biomarkers
Plasmodium falciparum

HAL domain(s) :

Sciences du Vivant [q-bio]/Médecine humaine et pathologie/Maladies infectieuses
Sciences du Vivant [q-bio]/Médecine humaine et pathologie/Urologie et Néphrologie

English abstract : [en]

BACKGROUND: Plasmodium falciparum malaria in India is characterized by high rates of severe disease, with multiple organ dysfunction (MOD)-mainly associated with acute renal failure (ARF)-and increased mortality. The ...
Show more >BACKGROUND: Plasmodium falciparum malaria in India is characterized by high rates of severe disease, with multiple organ dysfunction (MOD)-mainly associated with acute renal failure (ARF)-and increased mortality. The objective of this study is to identify cytokine signatures differentiating severe malaria patients with MOD, cerebral malaria (CM), and cerebral malaria with MOD (CM-MOD) in India. We have previously shown that two cytokines clusters differentiated CM from mild malaria in Maharashtra. Hence, we also aimed to determine if these cytokines could discriminate malaria subphenotypes in Odisha.METHODS: P. falciparum malaria patients from the SCB Medical College Cuttack in the Odisha state in India were enrolled along with three sets of controls: healthy individuals, patients with sepsis and encephalitis (n = 222). We determined plasma concentrations of pro- and anti-inflammatory cytokines and chemokines for all individuals using a multiplex assay. We then used an ensemble of statistical analytical methods to ascertain whether particular sets of cytokines/chemokines were predictors of severity or signatures of a disease category.RESULTS: Of the 26 cytokines/chemokines tested, 19 increased significantly during malaria and clearly distinguished malaria patients from controls, as well as sepsis and encephalitis patients. High amounts of IL-17, IP-10, and IL-10 predicted MOD, decreased IL-17 and MIP-1α segregated CM-MOD from MOD, and increased IL-12p40 differentiated CM from CM-MOD. Most severe malaria patients with ARF exhibited high levels of IL-17.CONCLUSION: We report distinct differences in cytokine production correlating with malarial disease severity in Odisha and Maharashtra populations in India. We show that CM, CM-MOD and MOD are clearly distinct malaria-associated pathologies. High amounts of IL-17, IP-10, and IL-10 were predictors of MOD; decreased IL-17 and MIP-1α separated CM-MOD from MOD; and increased IL-12p40 differentiated CM from CM-MOD. Data also suggest that the IL-17 pathway may contribute to malaria pathogenesis via different regulatory mechanisms and may represent an interesting target to mitigate the pathological processes in malaria-associated ARF.Show less >

Language :

Anglais

Popular science :

Non

ANR Project :

Alliance française contre les maladies parasitaires

Collections :

• Laboratoire Paul Painlevé - UMR 8524

Source :

Harvested from HAL