Title :

BACH2 promotes indolent clinical presentation in Waldenström macroglobulinemia

Author(s) :

Herbaux, Charles [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer - U837 [JPArc]
Bertrand, Elisabeth [Auteur]
Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer - U837 [JPArc]
Marot, Guillemette [Auteur]
Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS]
MOdel for Data Analysis and Learning [MODAL]
Roumier, Christophe [Auteur]
Service d'Hématologie Cellulaire [Lille]
Poret, Nicolas [Auteur]
Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer - U837 [JPArc]
Soenen, Valérie [Auteur]
Service d'Hématologie Cellulaire [Lille]
Nibourel, Olivier [Auteur]
Service d'Hématologie Cellulaire [Lille]
Roche-Lestienne, Catherine [Auteur]
Service d'Hématologie Cellulaire [Lille]
Broucqsault, Natacha [Auteur]
Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer - U837 [JPArc]
Galiègue-Zouitina, Sylvie [Auteur]
Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer - U837 [JPArc]
Boyle, Eileen [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Fouquet, Guillemette [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Renneville, Aline [Auteur]
Service d'Hématologie Cellulaire [Lille]
Tricot, Sabine [Auteur]
Centre hospitalier [Valenciennes, Nord]
Morschhauser, Franck [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Preudhomme, Claude [Auteur]
Service d'Hématologie Cellulaire [Lille]
Quesnel, Bruno [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer - U837 [JPArc]
Poulain, Stephanie [Auteur]
Centre hospitalier [Valenciennes, Nord]
Leleu, Xavier [Auteur]
Centre hospitalier universitaire de Poitiers = Poitiers University Hospital [CHU de Poitiers [La Milétrie]]

Journal title :

Oncotarget

Publisher :

Impact journals

Publication date :

2016

ISSN :

1949-2553

English keyword(s) :

BACH2
Waldenström macroglobulinemia
indolent
progression
physiopathology

HAL domain(s) :

Sciences du Vivant [q-bio]
Mathématiques [math]/Statistiques [math.ST]

English abstract : [en]

Approximately 30% of the patients who fulfil the criteria of Waldenström's macroglobulinemia (WM) are diagnosed while asymptomatic (indolent), and will not require immediate therapy. Conversely, patients with a disease-related ...
Show more >Approximately 30% of the patients who fulfil the criteria of Waldenström's macroglobulinemia (WM) are diagnosed while asymptomatic (indolent), and will not require immediate therapy. Conversely, patients with a disease-related event will be considered for therapy. The physiopathology of these 2 groups remains unclear, and the mechanisms of progression from indolent to symptomatic WM have yet to be fully understood. Seventeen patients diagnosed with WM were included in this study, 8 asymptomatic WM (A-WM) and 9 symptomatic WM (S-WM). A differential analysis was performed on a first series of 11 patients and identified 48 genes whose expression separated samples from A-to S-WM. This gene signature was then confirmed on a second independent validation set of 6 WM. Within this expression profile, BACH2, a B-cell transcription factor known to be a tumor suppressor gene, was found to be over-expressed in A-MW relatively to S-MW. We specifically over-expressed BACH2 in a WM-related cell line and observed a significant reduction of the clonogenic activity. To the best of our knowledge, we report for the first time a specific gene expression signature that differentiates A-WM and S-WM. Within this expression profile, BACH2 was identified as a candidate gene that may help to understand better the behavior of tumor cells in indolent WM.Show less >

Language :

Anglais

Popular science :

Non

Collections :

• Laboratoire Paul Painlevé - UMR 8524

Source :

Harvested from HAL