Title :

Diagnosis and Management of Hepatic Encephalopathy: The French Recommendations.

Author(s) :

Thabut, Dominique [Auteur]
Centre de Recherche Saint-Antoine [CRSA]
Bouzbib, Charlotte [Auteur]
Centre de Recherche Saint-Antoine [CRSA]
Meunier, Lucy [Auteur]
Hôpital Saint Eloi [CHU Montpellier]
Haas, Manon [Auteur]
Centre Hépato-Biliaire [Hôpital Paul Brousse] [CHB]
Weiss, Nicolas [Auteur]
Centre de Recherche Saint-Antoine [CRSA]
Louvet, Alexandre [Auteur]
Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
Service des Maladies de l'Appareil Digestif et de la Nutrition [CHRU Lille]
Imbert-Bismut, François [Auteur]
Service des Maladies de l'Appareil Digestif et de la Nutrition [CHRU Lille]
Mochel, Fanny [Auteur]
CHU Pitié-Salpêtrière [AP-HP]
Nadjar, Yann [Auteur]
CHU Pitié-Salpêtrière [AP-HP]
Santiago, Antoine [Auteur]
Centre de Recherche Saint-Antoine [CRSA]
Thevenot, Thierry [Auteur]
Hôpital JeanMinjoz
Duhalde, Véronique [Auteur]
Centre Hospitalier Universitaire de Toulouse [CHU Toulouse]
Oberti, Frédéric [Auteur]
Centre Hospitalier Universitaire d'Angers [CHU Angers]
Francoz, Claire [Auteur]
Hôpital Beaujon [AP-HP]
Coilly, Audrey [Auteur]
Centre Hépato-Biliaire [Hôpital Paul Brousse] [CHB]
Hilleret, Marie-Noelle [Auteur]
Centre Hospitalier Universitaire [CHU Grenoble] [CHUGA]
Lebray, Pascal [Auteur]
Centre de Recherche Saint-Antoine [CRSA]
Liou-Schischmanoff, Amélie [Auteur]
CHU Pitié-Salpêtrière [AP-HP]
Barbier, Louise [Auteur]
CHU Trousseau [Tours]
Duvoux, Christophe [Auteur]
Hôpital Henri Mondor
Pageaux, Georges-Philippe [Auteur]
Centre Hospitalier Régional Universitaire [Montpellier] [CHRU Montpellier]
Bismuth, Michael [Auteur]
Hôpital Saint Eloi [CHU Montpellier]
Galanaud, Damien [Auteur]
CHU Pitié-Salpêtrière [AP-HP]
De Broucker, Thomas [Auteur]
Centre Hospitalier de Saint-Denis [Ile-de-France]
Cadranel, Jean-François [Auteur]
Service d'Hépato-Gastroentérologie
Leroy, Vincent [Auteur]
Hôpital Henri Mondor
Di Martino, Vincent [Auteur]
Hôpital JeanMinjoz
Larrey, Dominique [Auteur]
Hôpital Saint Eloi [CHU Montpellier]
Camus, Christophe [Auteur]
Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou]
Scatton, Olivier [Auteur]
CHU Pitié-Salpêtrière [AP-HP]
De Ledinghen, Victor [Auteur]
Hôpital Haut-Lévêque [CHU Bordeaux]
Mallat, Ariane [Auteur]
Hôpital Henri Mondor
Rudler, Marika [Auteur]
Centre de Recherche Saint-Antoine [CRSA]
Bureau, Christophe [Auteur]
Centre Hospitalier Universitaire de Toulouse [CHU Toulouse]

Journal title :

Liver International

Abbreviated title :

Liver Int

Publication date :

2023-01-11

ISSN :

1478-3231

English keyword(s) :

ammonia
cirrhosis
hepatic encephalopathy
liver transplantation
TIPS

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Hepatic encephalopathy (HE) is a frequent and severe complication of liver disease with poor patient outcomes. However, it is a poorly understood complication, with no consensus for diagnosis. Therefore, HE is often ...
Show more >Hepatic encephalopathy (HE) is a frequent and severe complication of liver disease with poor patient outcomes. However, it is a poorly understood complication, with no consensus for diagnosis. Therefore, HE is often underdiagnosed. Differential diagnosis may be cumbersome because of non-specific symptoms, such as confusion, cognitive disorders, the aetiological factors of cirrhosis and comorbidities, which are often observed in cirrhotic patients. Therefore, an overt or covert form of HE should be systematically investigated. Advice is provided to drive patient work-up. Effective treatments are available to prevent or treat HE bouts, but the issue of single or combination therapy has not been resolved. Transjugular intrahepatic portosystemic shunt (TIPS) placement largely improved the prognosis of cirrhotic patients, but HE occurrence of HE is often a fear, even when post-TIPS HE can be avoided by a careful selection of patients and preventive treatment. HE is an indication of liver transplantation. However, its reversibility post-transplantation and the consequences of transplantation in patients with other causes of neurological disorders remain controversial, which supports the performance of an extensive work-up in expert centres for this subset of patients. The present guidelines assist clinicians in the diagnosis of the overt or covert form of HE to implement curative and preventive treatments and clarify which patients require referral to expert centres for consideration for liver transplantation. These guidelines are very clinically oriented and address different frequent clinical issues to help physicians make bedside decisions.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
Inserm
CHU Lille

Collections :

• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Submission date :

2024-01-11T23:39:45Z
2024-03-08T09:50:00Z