Title :

Low alcohol consumption influences outcomes in individuals with alcohol-related compensated cirrhosis in a French multicenter cohort.

Author(s) :

Louvet, Alexandre [Auteur]
Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
Bourcier, Valérie [Auteur]
Centre de Recherche des Cordeliers [CRC (UMR_S_1138 / U1138)]
Archambeaud, Isabelle [Auteur]
Centre Hospitalier Universitaire de Nantes = Nantes University Hospital [CHU Nantes]
D'alteroche, Louis [Auteur]
Centre Hospitalier Régional Universitaire de Tours [CHRU Tours]
Chaffaut, Cendrine [Auteur]
Epidemiology and Clinical Statistics for Tumor, Respiratory, and Resuscitation | Epidémiologie Clinique, STatistique, pour la Recherche en Santé [ECSTRRA [CRESS - U1153 / UMR_A 1125]]
Oberti, Frédéric [Auteur]
Centre Hospitalier Universitaire d'Angers [CHU Angers]
Moreno, Christophe [Auteur]

Roulot, Dominique [Auteur]
Centre de Recherche des Cordeliers [CRC (UMR_S_1138 / U1138)]
Dao, Thông [Auteur]
CHU Caen
Moirand, Romain [Auteur]
Centre Hospitalier Universitaire [Rennes]
Duclos-Vallée, Jean-Charles [Auteur]
Hôpital Paul Brousse
Goria, Odile [Auteur]
CHU Rouen
Nguyen-Khac, Eric [Auteur]
CHU Amiens-Picardie
Pol, Stanislas [Auteur]
Physiopathologie du système immunitaire [Inserm U1223]
Carbonell, Nicolas [Auteur]
CHU Saint-Antoine [AP-HP]
Gournay, Jerôme [Auteur]
Centre Hospitalier Universitaire de Nantes = Nantes University Hospital [CHU Nantes]
Elkrief, Laure [Auteur]
Centre Hospitalier Régional Universitaire de Tours [CHRU Tours]
Fouchard-Hubert, Isabelle [Auteur]
Université d'Angers [UA]
Chevret, Sylvie [Auteur]
Epidemiology and Clinical Statistics for Tumor, Respiratory, and Resuscitation | Epidémiologie Clinique, STatistique, pour la Recherche en Santé [ECSTRRA [CRESS - U1153 / UMR_A 1125]]
Ganne-Carrié, Nathalie [Auteur]
Centre de Recherche des Cordeliers [CRC (UMR_S_1138 / U1138)]

Journal title :

Journal of Hepatology

Abbreviated title :

J Hepatol

Volume number :

78

Pages :

501-512

Publication date :

2022-11-26

ISSN :

1600-0641

English keyword(s) :

recurrence
liver decompensation
cirrhosis
alcohol-related liver disease

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Background & Aims The harmful impact of heavy alcohol consumption and recurrence in patients with alcohol-related cirrhosis is long-established, although this is based on old studies. However, the drivers of long-term ...
Show more >Background & Aims The harmful impact of heavy alcohol consumption and recurrence in patients with alcohol-related cirrhosis is long-established, although this is based on old studies. However, the drivers of long-term outcome still need to be clearly investigated. Method All patients with biopsy-proven compensated alcohol-related cirrhosis included in the CIRRAL cohort (22 centers) were prospectively studied. Prognostic variables of survival and liver event-free survival were assessed using multivariable Cox models with stepwise selection. The prognostic impact of alcohol recurrence during follow-up (computed in glass-years in the same way as pack-years for tobacco) was assessed using a time-dependent covariable. Results From 2010 to 2016, 650 patients were included. The median age at baseline was 58.4 years, 67.4% were men and the median BMI was 27.8 kg/m2, 63.8% had a history of liver decompensation, and 70.2% had discontinued alcohol. At 5 years, recurrence occurred in 30.9% of abstinent patients and this risk was higher in patients with a history of drug abuse and in those with shorter alcohol discontinuation times. Median survival was 97 months. Age, alcohol consumption at baseline, platelet count and Child-Pugh score >5 were associated with overall and liver event-free survival on multivariate analysis. Alcohol consumption of more than 25 glass-years during follow-up was independently associated with lower survival and with a trend toward lower liver event-free survival, with the risk increasing from 1 glass-year, though not significantly. Simon & Makuch plots confirm the benefit of no alcohol consumption (<1 glass/week) on both outcomes and the dose-dependent impact of alcohol over time. Conclusion This prospective study in patients with compensated alcohol-related cirrhosis identifies factors predictive of alcohol recurrence during follow-up and shows that moderate alcohol consumption during follow-up negatively impacts outcomes. Patients with alcohol-related cirrhosis should be advised to completely stop drinking alcohol.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
Inserm
CHU Lille

Collections :

• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Submission date :

2024-01-12T00:00:04Z
2024-02-27T13:02:44Z