Title :

Venous thromboembolism during systemic inflammatory and autoimmune diseases associated with myelodysplastic syndromes, chronic myelomonocytic leukaemia and myelodysplastic/myeloproliferative neoplasms: a French multicentre retrospective case-control study.

Author(s) :

Péan De Ponfilly-Sotier, Marie [Auteur]
CHU Saint-Antoine [AP-HP]
Jachiet, Vincent [Auteur]
CHU Saint-Antoine [AP-HP]
Benhamou, Ygal [Auteur]
Endothélium, valvulopathies et insuffisance cardiaque [EnVI]
Lahuna, Constance [Auteur]
CHU Saint-Antoine [AP-HP]
De Renzis, Benoit [Auteur]
CHU Clermont-Ferrand
Kottler, Diane [Auteur]
CIC - CHU Bichat
Voillat, Laurent [Auteur]
Centre Hospitalier Chalon-sur-Saône William Morey
Dimicoli-Salazar, Sophie [Auteur]
Hôpital Haut-Lévêque [CHU Bordeaux]
Banos, Anne [Auteur]
Centre Hospitalier de la Côte Basque [CHCB]
Chauveheid, Marie-Paule [Auteur]
AP-HP - Hôpital Bichat - Claude Bernard [Paris]
Grignano, Eric [Auteur]
Hôpital Cochin [AP-HP]
Liferman, François [Auteur]
Laborde, Mathilde [Auteur]
Broner, Jonathan [Auteur]
Centre Hospitalier Universitaire de Nîmes [CHU Nîmes]
Michel, Marc [Auteur]
Hôpital Henri Mondor
Lambotte, Olivier [Auteur]
Hôpital Bicêtre [AP-HP, Le Kremlin-Bicêtre]
Laribi, Kamel [Auteur]
Centre Hospitalier Le Mans (CH Le Mans)
Venon, Marie-Dominique [Auteur]
Service de médecine interne [CHU Ambroise Paré]
Dussol, Bertrand [Auteur]
Hôpital de la Conception [CHU - APHM] [LA CONCEPTION]
Martis, Nihal [Auteur]
Centre Hospitalier Universitaire de Nice [CHU Nice]
Thepot, Sylvain [Auteur]
Centre Hospitalier Universitaire d'Angers [CHU Angers]
Park, Sophie [Auteur]
Centre Hospitalier Universitaire [CHU Grenoble] [CHUGA]
Couret, David [Auteur]
Roux-Sauvat, Marielle [Auteur]
Terriou, Louis [Auteur]
Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
Hachulla, Eric [Auteur]
Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
Bally, Cécile [Auteur]
Hôpital Necker - Enfants Malades [AP-HP]
Galland, Joris [Auteur]
Centre Hospitalier de Bourg en Bresse
Allain, Jean-Sebastien [Auteur]
Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou]
Parcelier, Anne [Auteur]
Peterlin, Pierre [Auteur]
Centre Hospitalier Universitaire de Nantes = Nantes University Hospital [CHU Nantes]
Cohen-Bittan, Judith [Auteur]
CHU Pitié-Salpêtrière [AP-HP]
Ackermann, Felix [Auteur]
Hôpital Foch [Suresnes]
Le Guen, Julien [Auteur]
Hôpital Européen Georges Pompidou [APHP] [HEGP]
Algrin, Caroline [Auteur]
Groupe Hospitalier Mutualiste [Grenoble] [GHM]
Charles, Pierre [Auteur]
Institut Mutualiste de Montsouris [IMM]
Daguindau, Etienne [Auteur]
Centre Hospitalier Régional Universitaire de Besançon [CHRU Besançon]
Puechal, Xavier [Auteur]
Hôpital Cochin [AP-HP]
Dunogue, Bertrand [Auteur]
Hôpital Cochin [AP-HP]
Blanchard-Delaunay, Claire [Auteur]
Centre Hospitalier Georges Renon [Niort] [CH Georges Renon Niort]
Beyne-Rauzy, Odile [Auteur]
Institut Universitaire du Cancer de Toulouse - Oncopole [IUCT Oncopole - UMR 1037]
Grobost, Vincent [Auteur]
CHU Estaing [Clermont-Ferrand]
Schmidt, Jean [Auteur]
CHU Amiens-Picardie
Le Gallou, Thomas [Auteur]
Centre Hospitalier Universitaire [Rennes]
Dubos-Lascu, Georgeta [Auteur]
Sonet, Anne [Auteur]
Denis, Guillaume [Auteur]
Roy-Peaud, Frédérique [Auteur]
Centre hospitalier universitaire de Poitiers = Poitiers University Hospital [CHU de Poitiers [La Milétrie]]
Fenaux, Pierre [Auteur]
Hopital Saint-Louis [AP-HP] [AP-HP]
Adès, Lionel [Auteur]
Hopital Saint-Louis [AP-HP] [AP-HP]
Fain, Olivier [Auteur]
CHU Saint-Antoine [AP-HP]
Mekinian, Arsène [Auteur]
CHU Saint-Antoine [AP-HP]

Journal title :

Clin Exp Rheumatol

Abbreviated title :

Clin Exp Rheumatol

Volume number :

40

Publication date :

2022-05-19

ISSN :

0392-856X

English keyword(s) :

venous thromboembolism
myelodysplastic syndrome
chronic myelomonocytic leukaemia
autoimmune diseases

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

OBJECTIVES: Myelodysplastic syndromes (MDS) and chronic myelomonocytic leukaemia (CMML) are associated with systemic inflammatory and autoimmune diseases (SIADs) in 10–30% of cases. The aims of this study were (i) to ...
Show more >OBJECTIVES: Myelodysplastic syndromes (MDS) and chronic myelomonocytic leukaemia (CMML) are associated with systemic inflammatory and autoimmune diseases (SIADs) in 10–30% of cases. The aims of this study were (i) to evaluate the prevalence of venous thromboembolism VTE in patients presenting with both MDS/CMML and SIADs, (ii) to describe risk factors associated with thrombosis, and (iii) to analyse the impact of VTE on overall survival and transformation to acute myeloid leukaemia in comparison to patients with MDS/CMML-associated SIADs without VTE. METHODS: This retrospective multicentre case-control study was conducted among patients with MDS/CMML and dysimmune disorders and featured in the French retrospective database of the French Network of Dysimmune Disorders Associated with Hemopathies (MINHEMON), diagnosed with MDS/CMML and dysimmune disorders. RESULTS: During a median follow-up of 16 months (5–48) VTE occurred in 35 patients (21.6 %) whereas 127 patients did not. Among those with VTE, 8 patients (22.9%) experienced two or more VTE. Common prothrombotic risk factors were not significantly different in patients with or without VTE. CMML was more frequent in patients without VTE (37 % vs. 14.3%, p=0.01), whereas myelodysplasic/myeloproliferative neoplasm (MDS/MPN) was higher in VTE patients (20 % vs. 5.5 %, p=0.01). In a multivariate analysis, only MDS/CMML progression at the time of VTE (odds ratio 28.82, 95 % CI (5.52–530.70) was significantly associated with VTE. When treated with an anticoagulation therapy, bleeding occurred in 19.4% of cases (6/31). Overall survival was not significantly different between patients with and without VTE (p=0.68). Leukaemia-free survival between groups was not significantly different (p=0.83). CONCLUSIONS: VTE is a common complication in MDS/CMML-associated SIADSs with an increased risk of bleeding when treated by anticoagulants. In the MDS/CMML subgroup, SIADS flares and MDS/CMML progression seem to be prothrombotic risk factors.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
Inserm
CHU Lille

Collections :

• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Submission date :

2024-01-12T01:27:30Z
2024-03-29T13:48:58Z