Title :

The gut environment regulates bacterial gene expression which modulates susceptibility to bacteriophage infection.

Author(s) :

Lourenço, Marta [Auteur]
Institut Pasteur [Paris] [IP]
Chaffringeon, Lorenzo [Auteur]
Centre de Recherche Saint-Antoine [CRSA]
Bactériophage, bactérie, hôte - Bacteriophage, bacterium, host
Lamy-Besnier, Quentin [Auteur]
Bactériophage, bactérie, hôte - Bacteriophage, bacterium, host
Titecat, Marie [Auteur]
Institute for Translational Research in Inflammation - U 1286 [INFINITE]
Pédron, Thierry [Auteur]
Institut Pasteur [Paris] [IP]
Sismeiro, Odile [Auteur]
Biomics (plateforme technologique)
Legendre, Rachel [Auteur]
Biomics (plateforme technologique)
Varet, Hugo [Auteur]
Pôle Biomics [C2RT]
Coppée, Jean-Yves [Auteur]
Biomics (plateforme technologique)
Bérard, Marion [Auteur]
De Sordi, Luisa [Auteur]
Centre de Recherche Saint-Antoine [CRSA]
Debarbieux, Laurent [Auteur]
Bactériophage, bactérie, hôte - Bacteriophage, bacterium, host

Journal title :

Cell Host and Microbe

Abbreviated title :

Cell Host Microbe

Volume number :

30

Pages :

556-569.e5

Publication date :

2022-04-17

ISSN :

1934-6069

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Abundance and diversity of bacteria and their viral predators, bacteriophages (phages), in the digestive tract are associated with human health. Particularly intriguing is the long-term coexistence of these two antagonistic ...
Show more >Abundance and diversity of bacteria and their viral predators, bacteriophages (phages), in the digestive tract are associated with human health. Particularly intriguing is the long-term coexistence of these two antagonistic populations. We performed genome-wide RNA sequencing on a human enteroaggregative Escherichia coli isolate to identify genes differentially expressed between in vitro conditions and in murine intestines. We experimentally demonstrated that four of these differentially expressed genes modified the interactions between E. coli and three virulent phages by either increasing or decreasing its susceptibility/resistance pattern and also by interfering with biofilm formation. Therefore, the regulation of bacterial genes expression during the colonization of the digestive tract influences the coexistence of phages and bacteria, highlighting the intricacy of tripartite relationships between phages, bacteria, and the animal host in intestinal homeostasis.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
Inserm
CHU Lille

Collections :

• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Submission date :

2024-01-12T01:44:19Z
2024-03-18T15:29:15Z