Title :

A European Survey on Digestive Perianastomotic Ulcerations, a Rare Crohn-Like Disorder Occurring in Children and Young Adults.

Author(s) :

Madre, Chrystele [Auteur]
AP-HP Hôpital universitaire Robert-Debré [Paris]
Mašić, M. [Auteur]
Prlenda-Touilleux, Daniela [Auteur]
Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] [CHU ST-E]
Brueckner, A. [Auteur]
Koletzko, S. [Auteur]
Fabre, Alexandre [Auteur]
Hôpital de la Timone [CHU - APHM] [TIMONE]
Marseille medical genetics - Centre de génétique médicale de Marseille [MMG]
Viala, Jérôme [Auteur]
Centre de recherche sur l'Inflammation [CRI (UMR_S_1149 / ERL_8252 / U1149)]
AP-HP Hôpital universitaire Robert-Debré [Paris]
Lima, R. [Auteur]
Enaud, Raphael [Auteur]
CIC Bordeaux
Centre Hospitalier Universitaire de Bordeaux [CHU Bordeaux]
Lemale, J. [Auteur]
Kolho, K. L. [Auteur]
Bergoin, Charlotte [Auteur]
Hospices Civils de Lyon [HCL]
Martinez-Vinson, C. [Auteur]
Dugelay, E. [Auteur]
Alvisi, P. [Auteur]
Aloi, M. [Auteur]
Miele, E. [Auteur]
Duclaux-Loras, R. [Auteur]
Nachury, Maria [Auteur]
Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
Languepin, Jane [Auteur]
CHU Limoges
Willot, Stephanie [Auteur]
Centre Hospitalier Régional Universitaire de Tours [CHRU Tours]
Dupont-Lucas, Claire [Auteur]
Nutrition, Inflammation et axe Microbiote-Intestin-Cerveau [ADEN]
Université de Caen Normandie [UNICAEN]
Mosca, A. [Auteur]
Tzivinikos, C. [Auteur]
Shamasneh, I. [Auteur]
Kolaček, S. [Auteur]
Hugot, J. P. [Auteur]

Journal title :

Journal of Pediatric Gastroenterology and Nutrition

Abbreviated title :

J Pediatr Gastroenterol Nutr

Publication date :

2021-06-20

ISSN :

1536-4801

English keyword(s) :

abdominal surgery
Crohn disease
digestive perianastomotic ulcerations
enteral nutrition
gut inflammation
Hirschsprung disease
ileocaecal valve
intestinal resection
necrotizing enterocolitis
short bowel syndrome

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Objectives: Digestive perianastomotic ulcerations (DPAU) resembling Crohn disease lesions are long-term complications of intestinal resections, occurring in children and young adults. They are known to be uncommon, severe ...
Show more >Objectives: Digestive perianastomotic ulcerations (DPAU) resembling Crohn disease lesions are long-term complications of intestinal resections, occurring in children and young adults. They are known to be uncommon, severe and difficult to treat. Methods: In the absence of recommendations, we performed a large European survey among the members of the ESPGHAN working group on inflammatory bowel disease (IBD) in order to collect the experience of expert pediatric gastroenterologists on DPAU. Results: Fifty-one patients (29 boys and 22 girls) were identified from 19 centers in 8 countries. Most patients were followed after necrotizing enterocolitis (n = 20) or Hirschsprung disease (n = 11). The anastomosis was performed at a median age (interquartile range) of 6 [1–23] months, and first symptoms occurred 39 [22–106] months after surgery. Anemia was the most prevalent symptom followed by diarrhea, abdominal pain, bloating, and failure to thrive. Hypoalbuminemia, elevated CRP, and fecal calprotectin were common. Deep ulcerations were found in 59% of patients usually proximally to the anastomosis (68%). During a median follow-up of 40 [19–67] months, treatments reported to be the most effective included exclusive enteral nutrition (31/35, 88%), redo anastomosis (18/22, 82%), and alternate antibiotic treatment (37/64, 58%). Conclusions: Unfortunately, persistence of symptoms, failure to thrive, and abnormal laboratory tests at last follow-up in most of patients show the burden of DPAU lacking optimal therapy and incomplete understanding of the pathophysiology.Show less >

Language :

Anglais

Peer reviewed article :

Oui

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
Inserm
CHU Lille

Collections :

• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Submission date :

2024-01-12T06:44:15Z
2024-03-01T08:56:41Z