Title :

Immune challenge induces differential corticosterone and interleukin-6 responsiveness in rats bred for extremes in anxiety-related behavior.

Author(s) :

Salome, N [Auteur]
Tasiemski, Aurélie [Auteur]
Neuroimmunologie des annélides [NA]
Dutriez, Isabelle [Auteur]
Université de Lille, Sciences et Technologies
Wigger, A [Auteur]
Landgraf, R [Auteur]
Viltart, Odile [Auteur]
Institut Pasteur de Lille
Université de Lille, Sciences et Technologies

Journal title :

Neuroscience

Abbreviated title :

Neuroscience

Volume number :

151

Pages :

1112-8

Publication date :

2008-02-19

ISSN :

0306-4522

English keyword(s) :

Adrenocorticotropic Hormone
Analysis of Variance
Animals
Anxiety
Behavior, Animal
Body Weight
Brain
Corticosterone
Cosyntropin
Disease Models, Animal
Interleukin-6
Lipopolysaccharides
Male
Protein Binding
Rats
Receptors, Corticotropin

HAL domain(s) :

Sciences cognitives

English abstract : [en]

Disturbances in mood such as anxiety and depression are often associated with altered hypothalamo-pituitary-adrenal (HPA) axis reactivity, but also with changes in cytokine production, such as interleukin-6 (IL-6), an ...
Show more >Disturbances in mood such as anxiety and depression are often associated with altered hypothalamo-pituitary-adrenal (HPA) axis reactivity, but also with changes in cytokine production, such as interleukin-6 (IL-6), an essential immune factor produced by macrophages and lymphocytes during inflammatory processes. The reciprocal relationship between the HPA axis and the immune system is now well established. In order to understand better the endocrine reactivity of anxious individuals faced with an immune challenge, a model of innate anxiety-related behavior, HAB and LAB rats (HABs, high and LABs, low anxiety-related behavior) was used in this study. We sought to determine whether injection of lipopolysaccharide (LPS) induced a differential HPA axis reactivity and plasma IL-6 release in HABs and LABs. After LPS injection, the plasma adrenal corticotrophic hormone increase did not differ between HABs and LABs, whereas a larger increase in plasma corticosterone levels occurred in HABs than in LABs at 2 h after injection. Moreover, basal IL-6 levels were lower in HABs than in LABs, leading to a higher IL-6 2 h/basal ratio in HABs. In conclusion, we propose for the first time a link between the endocrine and immune systems of HABs and LABs and suggest that IL-6 could be a neuroendocrine correlate of trait anxiety in HABs.Show less >

Language :

Anglais

Peer reviewed article :

Oui

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
CNRS
CHU Lille

Collections :

• Autres travaux scientifiques

Submission date :

2024-01-12T14:51:52Z
2024-02-28T09:47:17Z