Hallucinations in Alzheimer's disease: ...
Document type :
Article dans une revue scientifique
Permalink :
Title :
Hallucinations in Alzheimer's disease: failure to suppress irrelevant memories
Author(s) :
El Haj, Mohamad [Auteur]
Sciences Cognitives et Sciences Affectives (SCALab) - UMR 9193
Gallouj, Karim [Auteur]
Centre Hospitalier de Tourcoing
Psychologie : Interactions, Temps, Emotions, Cognition (PSITEC) - ULR 4072 [PSITEC]
Dehon, Hedwige [Auteur]
Université de Liège
Roche, Jean [Auteur]
Larøi, Franck [Auteur]
Université de Liège
University of Bergen [UiB]
Sciences Cognitives et Sciences Affectives (SCALab) - UMR 9193
Gallouj, Karim [Auteur]
Centre Hospitalier de Tourcoing
Psychologie : Interactions, Temps, Emotions, Cognition (PSITEC) - ULR 4072 [PSITEC]
Dehon, Hedwige [Auteur]
Université de Liège
Roche, Jean [Auteur]
Larøi, Franck [Auteur]
Université de Liège
University of Bergen [UiB]
Journal title :
Cognitive Neuropsychiatry
Abbreviated title :
Cognitive Neuropsychiatry
Volume number :
23
Pages :
p.142-153
Publisher :
Informa UK Limited
Publication date :
2018-02-26
English keyword(s) :
Alzheimer’s disease
hallucinations
inhibition
memory suppression
hallucinations
inhibition
memory suppression
HAL domain(s) :
Sciences cognitives
English abstract : [en]
Introduction: Research with patients with schizophrenia suggests that inhibitory dysfunction leads to the emergence of redundant or irrelevant information from long-term memory into awareness, and that this process may be ...
Show more >Introduction: Research with patients with schizophrenia suggests that inhibitory dysfunction leads to the emergence of redundant or irrelevant information from long-term memory into awareness, and that this process may be involved in generating hallucinations. We investigated whether inhibitory dysfunction in Alzheimer’s disease (AD) leads to hallucinations. Method: AD participants and healthy matched controls were assessed with a hallucinations scale and a directed forgetting task. On the directed forgetting task, they were asked to retain a list of 10 words (i.e., List 1). Thereafter, half of the participants were asked to forget this list whereas the other half were asked to retain the list in memory. After the List 1 presentation, all participants were asked to retain another list of 10 words and, successively, were asked to remember all of the words from both lists, regardless of the previous forget or remember instruction. Results: Relative to healthy matched controls, AD participants showed difficulties in suppressing the words from List 1. AD participants also showed more hallucinatory experiences than healthy matched controls. Interestingly, a significant correlation was observed between the score on the hallucinations measure and difficulties in suppressing List 1 in AD participants. Discussion: Hallucinations in AD may, at least in part, be related to difficulties in suppressing memory representations, such that unwanted or repetitive thoughts intrude into consciousness.Show less >
Show more >Introduction: Research with patients with schizophrenia suggests that inhibitory dysfunction leads to the emergence of redundant or irrelevant information from long-term memory into awareness, and that this process may be involved in generating hallucinations. We investigated whether inhibitory dysfunction in Alzheimer’s disease (AD) leads to hallucinations. Method: AD participants and healthy matched controls were assessed with a hallucinations scale and a directed forgetting task. On the directed forgetting task, they were asked to retain a list of 10 words (i.e., List 1). Thereafter, half of the participants were asked to forget this list whereas the other half were asked to retain the list in memory. After the List 1 presentation, all participants were asked to retain another list of 10 words and, successively, were asked to remember all of the words from both lists, regardless of the previous forget or remember instruction. Results: Relative to healthy matched controls, AD participants showed difficulties in suppressing the words from List 1. AD participants also showed more hallucinatory experiences than healthy matched controls. Interestingly, a significant correlation was observed between the score on the hallucinations measure and difficulties in suppressing List 1 in AD participants. Discussion: Hallucinations in AD may, at least in part, be related to difficulties in suppressing memory representations, such that unwanted or repetitive thoughts intrude into consciousness.Show less >
Language :
Anglais
Audience :
Internationale
Popular science :
Non
Administrative institution(s) :
Université de Lille
CNRS
CHU Lille
CNRS
CHU Lille
Collections :
Research team(s) :
Équipe Dynamique Émotionnelle et Pathologies (DEEP)
Submission date :
2024-01-15T12:59:36Z
2024-01-26T10:11:44Z
2024-01-26T10:12:40Z
2024-01-26T10:11:44Z
2024-01-26T10:12:40Z