Title :

Blood-brain crosstalk: the roles of neutrophils, platelets, and neutrophil extracellular traps in neuropathologies.

Author(s) :

Chou, Ming-Li [Auteur]
Babamale, Abdulkareem Olarewaju [Auteur]
Walker, Tara L. [Auteur]
Cognasse, Fabrice [Auteur]
Blum, David [Auteur]
Excellence Laboratory LabEx DISTALZ
Lille Neurosciences & Cognition (LilNCog) - U 1172
Burnouf, Thierry [Auteur]

Journal title :

Trends in Neurosciences

Publication date :

2023-09

ISSN :

1878-108X

English keyword(s) :

extracellular vesicles
neuroimmune
viral infection
neurodegeneration
neuroinflammation
Thromboinflammation

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Systemic inflammation, neurovascular dysfunction, and coagulopathy often occur concurrently in neuropathologies. Neutrophils and platelets have crucial synergistic roles in thromboinflammation and are increasingly suspected ...
Show more >Systemic inflammation, neurovascular dysfunction, and coagulopathy often occur concurrently in neuropathologies. Neutrophils and platelets have crucial synergistic roles in thromboinflammation and are increasingly suspected as effector cells contributing to the pathogenesis of neuroinflammatory diseases. In this review, we summarize the roles of platelet–neutrophil interactions in triggering complex pathophysiological events affecting the brain that may lead to the disruption of brain barriers, infiltration of toxic factors into the parenchyma, and amplification of neuroinflammation through the formation of neutrophil extracellular traps (NETs). We highlight the clinical significance of thromboinflammation in neurological disorders and examine the contributions of damage-associated molecular patterns (DAMPs) derived from platelets and neutrophils. These DAMPs originate from both infectious and non-infectious risk factors and contribute to the activation of inflammasomes during brain disorders. Finally, we identify knowledge gaps in the molecular mechanisms underlying neurodegenerative disease pathogenesis and emphasize the potential of interventions targeting platelets and neutrophils to treat neuroinflammatory diseases.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
Inserm
CHU Lille

Collections :

• Lille Neurosciences & Cognition (LilNCog) - U 1172

Submission date :

2024-01-15T22:35:38Z
2024-12-17T13:49:39Z