Titre :

Prodromal language impairment in genetic frontotemporal dementia within the GENFI cohort.

Auteur(s) :

Samra, Kiran [Auteur]
Macdougall, Amy M. [Auteur]
Bouzigues, Arabella [Auteur]
Bocchetta, Martina [Auteur]
Cash, David M. [Auteur]
Greaves, Caroline V. [Auteur]
Convery, Rhian S. [Auteur]
Van Swieten, John C. [Auteur]
Jiskoot, Lize [Auteur]
Seelaar, Harro [Auteur]
Moreno, Fermin [Auteur]
Sanchez-Valle, Raquel [Auteur]
Laforce, Robert [Auteur]
Graff, Caroline [Auteur]
Masellis, Mario [Auteur]
Tartaglia, Maria C. [Auteur]
Rowe, James B. [Auteur]
Borroni, Barbara [Auteur]
Finger, Elizabeth [Auteur]
Synofzik, Matthis [Auteur]
Galimberti, Daniela [Auteur]
Vandenberghe, Rik [Auteur]
De Mendonça, Alexandre [Auteur]
Butler, Chris R. [Auteur]
Gerhard, Alex [Auteur]
Ducharme, Simon [Auteur]
Le Ber, Isabelle [Auteur]
Tiraboschi, Pietro [Auteur]
Santana, Isabel [Auteur]
Pasquier, Florence [Auteur]
Lille Neurosciences & Cognition (LilNCog) - U 1172
Levin, Johannes [Auteur]
Otto, Markus [Auteur]
Sorbi, Sandro [Auteur]
Rohrer, Jonathan D. [Auteur]
Russell, Lucy L. [Auteur]

Titre de la revue :

Journal of the Neurological Sciences

Numéro :

451

Pagination :

120711

Date de publication :

2023-08-15

ISSN :

1878-5883

Mot(s)-clé(s) :

Frontotemporal dementia
Language
Genetic
Progranulin
C9orf72
MAPT

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

Objective To identify whether language impairment exists presymptomatically in genetic frontotemporal dementia (FTD), and if so, the key differences between the main genetic mutation groups. Methods 682 participants ...
Lire la suite >Objective To identify whether language impairment exists presymptomatically in genetic frontotemporal dementia (FTD), and if so, the key differences between the main genetic mutation groups. Methods 682 participants from the international multicentre Genetic FTD Initiative (GENFI) study were recruited: 290 asymptomatic and 82 prodromal mutation carriers (with C9orf72, GRN, and MAPT mutations) as well as 310 mutation-negative controls. Language was assessed using items from the Progressive Aphasia Severity Scale, as well as the Boston Naming Test (BNT), modified Camel and Cactus Test (mCCT) and a category fluency task. Participants also underwent a 3 T volumetric T1-weighted MRI from which regional brain volumes within the language network were derived and compared between the groups. Results 3% of asymptomatic (4% C9orf72, 4% GRN, 2% MAPT) and 48% of prodromal (46% C9orf72, 42% GRN, 64% MAPT) mutation carriers had impairment in at least one language symptom compared with 13% of controls. In prodromal mutation carriers significantly impaired word retrieval was seen in all three genetic groups whilst significantly impaired grammar/syntax and decreased fluency was seen only in C9orf72 and GRN mutation carriers, and impaired articulation only in the C9orf72 group. Prodromal MAPT mutation carriers had significant impairment on the category fluency task and the BNT whilst prodromal C9orf72 mutation carriers were impaired on the category fluency task only. Atrophy in the dominant perisylvian language regions differed between groups, with earlier, more widespread volume loss in C9orf72, and later focal atrophy in the temporal lobe in MAPT mutation carriers. Conclusions Language deficits exist in the prodromal but not asymptomatic stages of genetic FTD across all three genetic groups. Improved understanding of the language phenotype prior to phenoconversion to fully symptomatic FTD will help develop outcome measures for future presymptomatic trials.Lire moins >

Langue :

Anglais

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

Université de Lille
Inserm
CHU Lille

Collections :

• Lille Neurosciences & Cognition (LilNCog) - U 1172

Date de dépôt :

2024-01-15T22:47:03Z
2024-12-16T17:02:46Z