Title :

Anti-CD20 therapies in multiple sclerosis: From pathology to the clinic

Author(s) :

De Sèze, Jérôme [Auteur]
Maillart, Elisabeth [Auteur]
Gueguen, Antoine [Auteur]
Laplaud, David A. [Auteur]
Michel, Laure [Auteur]
Thouvenot, Eric [Auteur]
Zephir, Helene [Auteur]
Lille Neurosciences & Cognition (LilNCog) - U 1172
Zimmer, Luc [Auteur]
Biotti, Damien [Auteur]
Liblau, Roland S. [Auteur]

Journal title :

Frontiers in Immunology

Abbreviated title :

Front Immunol

Volume number :

14

Pages :

1004795

Publisher :

Frontiers

Publication date :

2023-03-23

ISSN :

1664-3224

English keyword(s) :

anti-CD20
ublituximab
ofatumumab
ocrelizumab
rituximab
multiple sclerosis

HAL domain(s) :

Sciences du Vivant [q-bio]
Sciences du Vivant [q-bio]/Immunologie

English abstract : [en]

The immune system plays a significant role in multiple sclerosis. While MS was historically thought to be T cell-mediated, multiple pieces of evidence now support the view that B cells are essential players in multiple ...
Show more >The immune system plays a significant role in multiple sclerosis. While MS was historically thought to be T cell-mediated, multiple pieces of evidence now support the view that B cells are essential players in multiple sclerosis pathogenic processes. High-efficacy disease-modifying therapies that target the immune system have emerged over the past two decades. Anti-CD20 monoclonal antibodies selectively deplete CD20+ B and CD20+ T cells and efficiently suppress inflammatory disease activity. These monotherapies prevent relapses, reduce new or active magnetic resonance imaging brain lesions, and lessen disability progression in patients with relapsing multiple sclerosis. Rituximab, ocrelizumab, and ofatumumab are currently used in clinical practice, while phase III clinical trials for ublituximab have been recently completed. In this review, we compare the four anti-CD20 antibodies in terms of their mechanisms of action, routes of administration, immunological targets, and pharmacokinetic properties. A deeper understanding of the individual properties of these molecules in relation to their efficacy and safety profiles is critical for their use in clinical practice.Show less >

Language :

Anglais

Peer reviewed article :

Oui

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
Inserm
CHU Lille

Collections :

• Lille Neurosciences & Cognition (LilNCog) - U 1172

Research team(s) :

Neuroinflammation & Multiple Sclerosis (NEMESIS)

Submission date :

2024-01-15T23:08:24Z
2024-11-22T08:58:54Z