The role of adenosine A <sub>2A</sub> receptors in Alzheimer's disease and tauopathies.

Launay, Agathe; Nebie, Ouada; Vijaya Shankara, Jhenkruth; Lebouvier, Thibaud; Buee, Luc; Faivre, Emilie; Blum, David

Type de document :

Article dans une revue scientifique: Article de synthèse/Review paper

DOI :

10.1016/j.neuropharm.2022.109379

PMID :

36572177

URL permanente :

http://hdl.handle.net/20.500.12210/101882

Titre :

The role of adenosine A <sub>2A</sub> receptors in Alzheimer's disease and tauopathies.

Auteur(s) :

Launay, Agathe [Auteur]
Equipe Alzheimer and Tauopathies - LilNCog [U1172 Inserm]
Nebie, Ouada [Auteur]
Lille Neurosciences & Cognition (LilNCog) - U 1172
Vijaya Shankara, Jhenkruth [Auteur]
Lille Neurosciences & Cognition - U 1172 [LilNCog]
Lebouvier, Thibaud [Auteur]

Lille Neurosciences & Cognition (LilNCog) - U 1172
Buee, Luc [Auteur]

Lille Neurosciences & Cognition (LilNCog) - U 1172
Faivre, Emilie [Auteur]
Lille Neurosciences & Cognition (LilNCog) - U 1172
Blum, David [Auteur]

Lille Neurosciences & Cognition (LilNCog) - U 1172

Titre de la revue :

NEUROPHARMACOLOGY

Pagination :

109379

Date de publication :

2022-12-28

ISSN :

1873-7064

Mot(s)-clé(s) :

Purinergic signaling
Adenosine
Adenosine receptors
A 2A receptor
Alzheimer?s disease
Amyloid
Tau

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

Adenosine signals through four distinct G protein-coupled receptors that are located at various synapses, cell types and brain areas. Through them, adenosine regulates neuromodulation, neuronal signaling, learning and ...
Lire la suite >Adenosine signals through four distinct G protein-coupled receptors that are located at various synapses, cell types and brain areas. Through them, adenosine regulates neuromodulation, neuronal signaling, learning and cognition as well as the sleep-wake cycle, all strongly impacted in neurogenerative disorders, among which Alzheimer's Disease (AD). AD is a complex form of cognitive deficits characterized by two pathological hallmarks: extracellular deposits of aggregated β-amyloid peptides and intraneuronal fibrillar aggregates of hyper- and abnormally phosphorylated Tau proteins. Both lesions contribute to the early dysfunction and loss of synapses which are strongly associated to the development of cognitive decline in AD patients. The present review focuses on the pathophysiological impact of the A2ARs dysregulation observed in cognitive area from AD patients. We are reviewing not only evidence of the cellular changes in A2AR levels in pathological conditions but also describe what is currently known about their consequences in term of synaptic plasticity, neuro-glial miscommunication and memory abilities. We finally summarize the proof-of-concept studies that support A2AR as credible targets and the clinical interest to repurpose adenosine drugs for the treatment of AD and related disorders. This article is part of the Special Issue on "Purinergic Signaling: 50 years".Lire moins >

Langue :

Anglais

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

Université de Lille
Inserm
CHU Lille

Collections :

Lille Neurosciences & Cognition (LilNCog) - U 1172

Équipe(s) de recherche :

Alzheimer et Tauopathies

Date de dépôt :

2024-01-15T23:58:36Z
2024-12-04T12:50:58Z

Numéro de version	Lien	Date de modification
2	20.500.12210/101882*	2024-12-04T12:44:09Z
1	20.500.12210/101882.1	2024-01-15T23:58:36Z

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The role of adenosine A <sub>2A</sub> ...

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