Functional changes in prefrontal cortex following frequency-specific training

Bach-Morrow, Lana; Boccalatte, Francesco; Derosa, Antonio; Devos, David; Garcia-Sanchez, Carmen; Inglese, Matilde; Droby, Amgad

Document type :

Article dans une revue scientifique: Article original

DOI :

10.1038/s41598-022-24088-7

PMID :

36434008

Permalink :

http://hdl.handle.net/20.500.12210/101911

Title :

Functional changes in prefrontal cortex following frequency-specific training

Author(s) :

Bach-Morrow, Lana [Auteur]
Boccalatte, Francesco [Auteur]
New York University Langone Medical Center [NYU Langone Medical Center]
Derosa, Antonio [Auteur]
University of Maryland [College Park]
Devos, David [Auteur]

Département de neurologie [Lille]
Lille Neurosciences & Cognition (LilNCog) - U 1172
Garcia-Sanchez, Carmen [Auteur]
Hospital de la Santa Creu i Sant Pau
Inglese, Matilde [Auteur]
Icahn School of Medicine at Mount Sinai [New York] [MSSM]
Droby, Amgad [Auteur]
Icahn School of Medicine at Mount Sinai [New York] [MSSM]

Journal title :

Scientific Reports

Volume number :

Pages :

20316

Publisher :

Nature Publishing Group

Publication date :

2022-11-24

ISSN :

2045-2322

English keyword(s) :

Biotechnology
Imaging techniques
Medical research
Neural circuits
Neurology
Neuroscience

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Numerous studies indicate a significant role of pre-frontal circuits (PFC) connectivity involving attentional and reward neural networks within attention deficit hyperactivity disorder (ADHD) pathophysiology. To date, the ...
Show more >Numerous studies indicate a significant role of pre-frontal circuits (PFC) connectivity involving attentional and reward neural networks within attention deficit hyperactivity disorder (ADHD) pathophysiology. To date, the neural mechanisms underlying the utility of non-invasive frequency-specific training systems in ADHD remediation remain underexplored. To address this issue, we created a portable electroencephalography (EEG)-based wireless system consisting of a novel headset, electrodes, and neuro program, named frequency specific cognitive training (FSCT). In a double-blind, randomized, controlled study we investigated the training effects in N = 46 school-age children ages 6–18 years with ADHD. 23 children in experimental group who underwent FCST training showed an increase in scholastic performance and meliorated their performance on neuropsychological tests associated with executive functions and memory. Their results were compared to 23 age-matched participants who underwent training with placebo (pFSCT). Electroencephalogram (EEG) data collected from participants trained with FSCT showed a significant increase in 14–18 Hz EEG frequencies in PFC brain regions, activities that indicated brain activation in frontal brain regions, the caudate nucleus, and putamen. These results demonstrate that FSCT targets specific prefrontal and striatal areas in children with ADHD, suggesting a beneficial modality for non-invasive modulation of brain areas implicated in attention and executive functions.Show less >

Language :

Anglais

Peer reviewed article :

Oui

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
Inserm
CHU Lille

Collections :

Lille Neurosciences & Cognition (LilNCog) - U 1172

Research team(s) :

Troubles cognitifs dégénératifs et vasculaires

Submission date :

2024-01-16T00:18:46Z
2024-12-06T16:05:20Z

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s41598-022-24088-7.pdf
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Except where otherwise noted, this item's license is described as Attribution 3.0 United States

Version	Link	Modification date
2	20.500.12210/101911*	2024-12-06T15:56:30Z
1	20.500.12210/101911.1	2024-01-16T00:18:46Z

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Functional changes in prefrontal cortex ...

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